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Migraine Medications Compared

Other names: Complicated Migraine; Hemiplegic Migraine; Migraine Headache

There are two main types of medications for migraine attacks:

  • Abortive treatments (those that stop a migraine in its tracks)
  • Preventive medications (those medications that keep migraines from coming back).

Acute medications (abortive treatments) for migraine

These treat a migraine once it has already started. They provide quick relief and are available as oral or sublingual tablets or wafers, injections, skin patches, or nasal sprays. They include:

Preventive medications for migraine

Preventive medications may be considered if migraines occur frequently, for example, more than one migraine per week; or if migraine symptoms are severe. The goal is to lessen the frequency and severity of the migraine attacks. Medication to prevent a migraine is usually taken daily. Preventive medications for migraine include:

Drugs used to treat Migraine

The medications listed below are related to or used in the treatment of this condition.

Filter
Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
sumatriptan 7.5 448 reviews for sumatriptan to treat Migraine
Rx C N
Generic name:
sumatriptan systemic
Brand names:
Imitrex, Imitrex Statdose, Zembrace SymTouch, Onzetra Xsail, Tosymra
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Imitrex 7.7 174 reviews for Imitrex to treat Migraine
Rx C N
Generic name:
sumatriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Ubrelvy 6.1 236 reviews for Ubrelvy to treat Migraine
Rx N
Generic name:
ubrogepant systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Nurtec ODT 6.1 235 reviews for Nurtec ODT to treat Migraine
Rx N
Generic name:
rimegepant systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
rizatriptan 8.3 327 reviews for rizatriptan to treat Migraine
Rx C N
Generic name:
rizatriptan systemic
Brand names:
Maxalt, Maxalt-MLT, RizaFilm
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Maxalt 8.7 123 reviews for Maxalt to treat Migraine
Rx C N
Generic name:
rizatriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
onabotulinumtoxinA 5.8 25 reviews for onabotulinumtoxinA to treat Migraine
Rx C N
Generic name:
onabotulinumtoxinA systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
rimegepant 6.2 239 reviews for rimegepant to treat Migraine
Rx N
Generic name:
rimegepant systemic
Brand name:
Nurtec ODT
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
ubrogepant 6.1 237 reviews for ubrogepant to treat Migraine
Rx N
Generic name:
ubrogepant systemic
Brand name:
Ubrelvy
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
atogepant Rate Add review
Rx N
Generic name:
atogepant systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
erenumab Rate Add review
Rx N
Generic name:
erenumab systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
galcanezumab Rate Add review
Rx N
Generic name:
galcanezumab systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
gabapentin Off-label 7.9 120 reviews for gabapentin to treat Migraine
Rx C N X
Generic name:
gabapentin systemic
Drug class:
gamma-aminobutyric acid analogs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Relpax 8.6 150 reviews for Relpax to treat Migraine
Rx C N
Generic name:
eletriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Excedrin Migraine 7.6 111 reviews for Excedrin Migraine to treat Migraine
OTC N N X
Generic name:
acetaminophen / aspirin / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
cyclobenzaprine Off-label 7.6 46 reviews for cyclobenzaprine to treat Migraine
Rx B N X
Generic name:
cyclobenzaprine systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Zomig 7.0 96 reviews for Zomig to treat Migraine
Rx C N X
Generic name:
zolmitriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Cambia 7.2 57 reviews for Cambia to treat Migraine
Rx D N X
Generic name:
diclofenac systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Treximet 9.1 90 reviews for Treximet to treat Migraine
Rx C N X
Generic name:
naproxen / sumatriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Amerge 8.4 29 reviews for Amerge to treat Migraine
Rx C N
Generic name:
naratriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Fiorinal 8.6 51 reviews for Fiorinal to treat Migraine
Rx C 3 X
Generic name:
aspirin / butalbital / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Maxalt-MLT 8.7 73 reviews for Maxalt-MLT to treat Migraine
Rx C N
Generic name:
rizatriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
diclofenac 7.3 67 reviews for diclofenac to treat Migraine
Rx D N X
Generic name:
diclofenac systemic
Brand name:
Cambia
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
naratriptan 8.4 49 reviews for naratriptan to treat Migraine
Rx C N
Generic name:
naratriptan systemic
Brand name:
Amerge
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
aspirin / butalbital / caffeine 8.9 89 reviews for aspirin / butalbital / caffeine to treat Migraine
Rx C 3 X
Generic name:
aspirin / butalbital / caffeine systemic
Brand names:
Fiorinal, Fortabs
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information

Frequently asked questions

View more FAQ

Topics under Migraine

Learn more about Migraine

Care guides

Symptoms and treatments

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.