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Quetiapine for Depression User Reviews (Page 3)

Brand names: Seroquel, Seroquel XR

Quetiapine has an average rating of 6.4 out of 10 from a total of 179 reviews for the treatment of Depression. 53% of reviewers reported a positive experience, while 27% reported a negative experience.

Reviews for Quetiapine

  • Mia
  • Taken for 1 to 6 months
  • September 29, 2018

Seroquel XR (quetiapine) "I got prescribed Seroquel XR for my sleep and it is supposed to help me with my sleeping and it does. I don’t follow a specific roster of when I’m meant to take it so I’m on and off every week and I only just started noticing that when I start taking it after a while of not taking it my depression gets worse. I’m not really sure of what’s going on."

3 / 10
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  • Queti...
  • Taken for 6 months to 1 year
  • May 24, 2017

"I was diagnosed with Delusional Jealousy in November 2016. I was utterly convinced my wife was cheating on me despite no evidence to support this irrational belief. The lack of evidence just made me even more suspicious. I was out of control. Taking Prozac and Lorazepam to try and control the anxiety was making things worse. A private Psychiatrist diagnosed me and prescribed quetiapine 300mg. The first 2 weeks were a bit groggy but I kept fit, ate healthily and went to bed early. The results were astonishing. I was immediately so much calmer and rational. At the very least this drug saved my marriage and at best it has probably saved my life. Yes I'm hungry all the time and have to be careful with food, but it's a small price to pay."

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  • sick...
  • Taken for 1 to 6 months
  • August 26, 2015

Seroquel XR (quetiapine) "Hate this med. Constantly sick on it. Stomach pain, severe diarrhea, passing out, severe dizziness and unable to wake up. Hungry for food all the time. Nasty taste in mouth. Thirsty all the time. Can't motivate myself to do anything. This was on the lowest dose available. Won't take it ever again don't care what my doctor says. No way."

1 / 10
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Frequently asked questions

  • Dee
  • Taken for 1 to 6 months
  • May 11, 2019

"Found quetiapine very helpful as sleep aid for my daughter at low dose but as I increased dose made her anxiety and depression worsen. This is our seventh medication. I am now proceeding with pharma genetic testing through saliva in hopes that through testing her DNA we can find appropriate medication match for my daughter. Hope this helps someone out there."

2 / 10
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  • Tom...
  • June 13, 2015

"I have been struggling to find a medication for my simple depression for about a year in a half now, basically tried all ssri's and s couple of others, I am now on 40 mg of prozac ( which I feel like I don't need) and 150 mg of regular seroquel before bed, the xr made me really tired and moody, plus the expense was outrageous, but trying the regular I finally feel myself again, although its my first day taking it I feel balanced out and basically normal again. Ps if your struggling out their keep fighting! God put the hardest problems on us for a reason!"

9 / 10
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Are you taking this medicine?

  • Kat
  • Taken for 5 to 10 years
  • March 3, 2013

"I have been taking between 150-300mg of quetiapine for 5 years. This medicine has transformed my life and combined with venlafaxine it keeps my depression, anxiety and anorexia at bay. The tiredness is a small price to pay for being able to work full time and greatly reduce the need for psych admissions."

10 / 10
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  • dev
  • Taken for 1 to 6 months
  • September 20, 2019

"I went on Seroquel for psychotic depression. I also suffer from ADHD and I'm on stimulants. I've been on it for a few months now and I've just started school, and the brain fog has really been screwing me over academically. Other than that, it's helpful but far too sedating. I've done horribly in all my assessments despite studying because it's like my brain isn't working. My teachers are all concerned about my performance. I take a dose of 300mg. I haven't had much weight gain but I feel really stiff all the time. I've constantly been late to school and passing out because of this med, so I can't even show up to school. It works pretty well but it's way too sedating and neutralizes all my thoughts. Switching from XR to IR somewhat helped but I'm still having a ton of issues."

5 / 10
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  • Mop
  • June 6, 2019

"Seroquel did slightly help with my anxiety & depression, more-so depression, though the doctor prescribed me this for the diagnosis of Bipolar (later found out I was misdiagnosed after diff. 2nd opinion) Side effects experienced: Fatigue, dizziness/lightheadedness(normally experience this quite often, but Seroquel increased frequency), weight gain/increased appetite. Gained 10lbs within 3-4 months & I'm the type of person that can eat as much as I want and won't gain anything, but on Seroquel I definitely did, this messed with my mental health even more & in the end caused me more depression & anxiety. Seroquel also made me incredibly irritable. It was very easy for me to get upset & angry. I also got some odd feeling of restlessness in my body after each time I took the next pill, especially at 100mg (stopped at 150mg, my highest dose), & going to sleep was the only way the feeling went away. The withdrawal was awful, as I experienced insomnia for 2 weeks. Overall...I did not like Seroquel."

2 / 10
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  • Tom...
  • Taken for 2 to 5 years
  • January 29, 2018

Seroquel XR (quetiapine) "First, I'm not schizophrenic, nor have I been diagnosed as bipolar.. I take this for drug induced anxiety I was initially given Seroquel XR because I exhibited rapid speech & a disorganized thought pattern during my (continual) intoxication by kratom. Kratom is a 'natural', legal substance with opioid and stimulant qualities. Well, I noticed right off that Seroquel XR calmed my racing thoughts. I saw this as a benefit -- but the next move was for me to quit using kratom. I got help for that via SUBOXONE, which I'm still on. My whole life & way of thinking took a sharp turn for the better. I remain on the Seroquel XR, along with the SUBOXONE. When I questioned the continued need for Seroquel XR, my Dr. simply said, "Look, you're doing great. Why change a thing?" And he's right. So Seroquel XR remains a part of my daily recipe for success."

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  • mtb
  • Taken for 1 to 6 months
  • October 26, 2016

"I am 65 and have PTSD from the loss of my son. I was prescribed Xanax and Klonipin for a few yrs but they did not deal with the panic attacks that I was experiencing. I cannot take SSRIs due to side effects, so I mentioned the Seroquel to my doctor who said it did have a mild anti depressant effect. I take .25 mg in the morning, and 3 of them at night . No weight gain, I am very active. If anything, my appetite has fallen. I sleep 8 hrs REM sleep and don't really need as much of the xanax or klonipin now. The Seroquel has helped me function greatly and won't allow the panic to set in. So, I am happy with it."

10 / 10
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  • Happy...
  • April 10, 2012

Seroquel (quetiapine) "After a 6 week period of a severe depressive episode with panic attacks and extreme anxiety, I checked myself into the hospital. The doctor completely changed my meds to Prozac, Wellbutrin, Klonopin, and at bedtime 10 mg Ambien and 400 mg Seroquel. This combination has worked wonders for me. I started falling and staying asleep for a good 8 hours, my ruminating has stopped almost completely, and my depression has really lifted. I attribute a lot of that to the Seroquel, in that it augments the effects of my antidepressants, stops my mind from racing, and has me sleeping well. The two side effects I've had are grogginess (which has gotten better) and the munchies. I keep fresh fruits and veggies handy at night to snack on instead of junk."

9 / 10
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  • Angry...
  • April 11, 2012

Seroquel XR (quetiapine) "Was taken off Geodon because of night-time anxiety and put on Seroquel XR. I feel so unmotivated. Sedated. I no more feel better by afternoon when it's time to take it again. I dread the next dose. Haven't felt this depressed in a while."

1 / 10
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  • Rough...
  • Taken for less than 1 month
  • December 18, 2018

"Hi. My daughter is 20 and she is on this drug for psychosis after major depression. After 1 week of 50mg, I do not see a change at all. So after 1 week the dosage has been increased to 100mg. Today she had the worst and scariest episode. She was yelling, screaming, shaking, crying, and scared so scared. I really don't know what to do. Can someone tell me is this normal after 1 week of being on the drug? And when will this start working and decrease the symptoms? I don't know how much more I can handle."

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  • Moano
  • Taken for less than 1 month
  • May 25, 2020

"I was prescribed quetiapine about two days ago for derealization/Bipolar/Anxiety/Depression. After taking 25 mg before bed, well, it’s definitely a sedative. I was basically in between sleep and awake having a panic attack. I had crazy dreams & the next day I feel worse. I don’t plan on taking it anymore because it was an unsettling, for lack of a better word, experience. This wasn’t for me, personally. I used goodrx to only pay $9 for the medication. And PlushCare to talk to an MD for $100."

2 / 10
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  • Bano
  • Taken for 1 to 6 months
  • April 13, 2020

"Asked my psychiatrist not to prescribe me these for antidepressants cause I had them as sleeping pills in a smaller dose when I was younger and became addicted to it could not sleep without multiple pills, they did not listen and gave me it for depression and it’s been months now because they said I had to give it a long try and I’m miserable I feel like a zombie everyday I cry and get angry at the smallest things I was better off with no medication than with these and I have gained 15 pounds so yeah not for me"

1 / 10
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  • Angela
  • Taken for 2 to 5 years
  • June 22, 2018

"I have had depression on and off for the last 30 years of my life. I have been on many different types of antidepressant but it never working well and I got all sorts of side effects like anxiety and jittery feeling in the body. My depression gets worse when I don’t get enough sleep or can’t fall asleep for a few days. Three years ago, my doctor prescribe Seroquel medication to me and it really help me. I started with 50 mg and now I am taking 150mg. 50mg of the XD and 100mg of the regular release for the last few months. This combination helps me fall asleep and go back to sleep when I wake up. This has no side effects on me besides feeling great in the morning."

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  • Anony...
  • Taken for 1 to 6 months
  • March 30, 2016

Seroquel XR (quetiapine) "It was mainly prescribed as a sleep aid, in addition to its antidepressant qualities. I was on regular Seroquel and now on XL as I have trouble staying asleep. It's slightly better. I'm getting 6 hours of sleep a night. I am not usually groggy or snowed by this, maybe once per 30 doses. I'm ok with it. Only downside is cost (XL is brand)"

8 / 10
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  • AlexisM
  • November 6, 2017

Seroquel XR (quetiapine) "I've been on this for 4-5 years and it is my rock. It literally helps me so much, I couldn't have made it through high school without it. Honestly it's what helped me through my suicidal phases. I still get them but it's not as intense and I don't try and act on it anymore."

10 / 10
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  • Ms 123
  • Taken for less than 1 month
  • November 10, 2015

"I have been taking this for 3 weeks and I completely came off Valium I was on for 11 months on the day of taking this. I noticed a change on the 2nd week and I feel more calmer and have the ability to make more concise and clear decisions, I do not act out of anger any more, I will take my time to analyse a situation and before time has gone I realise the situation no longer bothers me! Great Med Low dose for Depression Anger issues!"

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  • Merry...
  • Taken for 6 months to 1 year
  • April 26, 2018

"I suffer from depression after loosing my husband two years ago. I tried other medication but had side effects I couldn't tolerate. Since being on this medication my depression is not as severe and I am finally able to cope with life. It helps me to have a good night sleep but I find in order to wake up without feeling groggy I must take it around 7 pm if I am waking up between 5:30 and 6:30 in the morning. (I take 50mg). The only side effect I have had is restless leg syndrome (RLS) on occasion. Other than that it's the best medication I have tried for depression."

8 / 10
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  • Someg...
  • Taken for 2 to 5 years
  • July 6, 2017

"First of all, for all the people writing reviews that haven't been on this drug for AT LEAST 4-6 WEEKS your reviews are almost invalid, this drug is as two-faced as many make it out to be and for those people they just aren't giving it enough time to see both sides of it. I have been on and off Seroquel for a few years now and currently taking 150mg at night for the past 3 months. It helped with anxiety and sleep which was great! I was less intimidated and anxious at school and with friends. However, it seriously affected my mood, constantly shifting from agitated to blunted, my concentration, my dreams, weight and eventually, over the course of about six weeks, caused one of the most serious relapses in my depression in years. Be careful!"

3 / 10
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  • Bueler
  • November 7, 2011

Seroquel XR (quetiapine) "The first night I took this medication, I almost ran out of breath before climbing the stairs from the basement to my room (it's as if my respiratory system was somewhat repressed). It also caused some chest/heart pain. On the other hand, I slept well for those two nights. The side effects may be more dangerous than one's condition. Please be careful."

5 / 10
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  • lilly...
  • Taken for 5 to 10 years
  • March 10, 2017

"I've been on quetiapine for a few years, I have had weight gain and I've put on a lot weight and now I'm diabetic type 2, but for me its been a small price to pay, I've have tried a lot of different drugs (antidepressants) over many years but for me quetiapine has saved my life in many ways before taking this drug I was very ill, I wanted to die not because I hated life or anything like that but I wanted to stop my awful thoughts I couldn't cope with anything in life, many times I was seeing things my life was hell, not sleeping, not going out fearful all the time, Even though I still have problems I never go anywhere on my own not even out by the front door,I know this drug has given me a small part of my life back."

10 / 10
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  • Anonymous
  • April 10, 2009

Seroquel XR (quetiapine) "I was put on this medicine very aggressively (200mg, quickly upped to 400mg) after a suicide attempt. As an antidepressant it is more effective than the first line medications like citalopram. And will help with sleep and a lack of hunger. However I absolutely hate the side effects. It is often said that antipsychotics "steal your soul" or act like a "mental prison". I would have to agree. To begin with this was fine, with severe depression I was happy to take any way out. However after about 6 months of this I decided enough was enough. Now I'm off it my personality is back."

6 / 10
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  • Anonymous
  • November 26, 2010

Seroquel (quetiapine) "I've been taking Seroquel (100mgs) for 2 months now. It's been great. I've had treatment resistant depression for years and have taken every antidepressant on the market with little to no help. I was running out of energy and time. After trying Abilify (bad akathesia), Lamictal (still taking), we tried Seroquel and within a 2 week period I was back in life. What a wonderful gift. I'm very thankful. Also, I've had refractory insomnia that has been alleviated as well."

10 / 10
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40 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.