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Lubiprostone User Reviews & Ratings (Page 3)

Brand names: Amitiza

Lubiprostone has an average rating of 5.6 out of 10 from a total of 272 reviews on Drugs.com. 45% of reviewers reported a positive experience, while 38% reported a negative experience.

Reviews for Lubiprostone

  • Anonymous
  • October 26, 2010

Amitiza (lubiprostone) for Irritable Bowel Syndrome with Constipation "I have had a pain in my left lower abdomen for a month and a half now. I finally went to the doctor yesterday and he told me it sounds like IBS. I have a GI appointment just to make sure. He gave me Amitiza to try till then. I was weary to try Amitiza because so many reviews talked of bad side effects. I ate a very full meal and took it last night. This morning I had no pain for the first time in a month and a half. I felt it some during the day but nothing like it has been. Definitely a miracle drug! I had little side effects, some nausea and a bit of feeling "not all there". But that was just a short time and it all went away. I can definitely handle the side effects when it works so well. I hope this review helps."

10 / 10
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  • Atlan...
  • Taken for 1 to 2 years
  • May 27, 2017

Amitiza (lubiprostone) for Irritable Bowel Syndrome with Constipation "I started taking Amitiza 8mcg twice a day about a year ago. At first I didn't notice anything. I have really bad bloating issues due to slow motility in large intestines. He then increased my dosage to 24 mcg twice a day and that's when my bloating decreased. Im able to eat foods I couldn't eat before. It does give me diarrhea badly at times but it doesn't bother me. I would give it a 10 but I still feel like there is something in my low intestines. Like it's not completely moving everything out of me. If I don't take it for a few days I do notice the bloating get worse. I definitely feel a whole lot better taking it than if I don't."

9 / 10
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  • Bunky...
  • June 23, 2017

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "In the first week I took Amitiza, I thought it was going to be a miracle answer to my chronic constipation. But I had a side effect of severe headaches almost every day....and sometimes all day long. Since I already have migraines, I blamed it on them getting worse.....even though the symptoms were different. First the headache would start, and within 5-10 minutes a gush of uncontrollable diarrhea. I kept blaming it all on migraines and seeking treatment for them. Finally, because of the expense of this one medication and having to take so many more, I had to stop taking Amitiza. Within just a few days, the headaches with diarrhea stopped. This is an excellent product if you don't have the side effects."

4 / 10
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Frequently asked questions

  • Jenni...
  • May 7, 2010

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "I was nervous taking this after reading the reviews, but this medicine has been great! I first started out taking the 8mg twice a day, and was using the bathroom every third day. I moved up to the 24mg twice a day, and I actually use the bathroom once a day. The first time I took it, I did have stomach cramping during the night, but that just lasted for one night. I have had no side effects what so ever. My stool is actually what it is supposed to look like and I feel great. I used to be on Zelnorm and I miss that so much, but this medicine seems to do its trick. Hopefully this one will stay on the market. Don't be afraid of trying this at all after reading some other reviews."

10 / 10
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  • Nurse...
  • Taken for 1 to 2 years
  • August 5, 2017

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "I've been on Amitiza for about a year, and while it works, it doesn't work as well as If like it to. I tried the 24 mcg dose at first but it was way too strong, definitely makes you run to the bathroom all day. I then switched to the 8mcg capsules twice a day. If I take them on an empty stomach, I get really nauseated, so I usually take them with a meal. I still had to use Miralax and fiber along with the Amitiza to ensure I stayed regular. Sometimes with all of this, I still got constipated, so I would take a 24mcg dosage and deal with the aftermath. When I did have a BM with Amitiza, it wasn't a "complete " one. It would make me poop out water, but it felt like the bulk of the stool was still left inside. I stopped taking it."

5 / 10
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Are you taking this medicine?

  • Anonymous
  • May 22, 2009

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "Had side effects - not even understanding it was from this medication. Went to Doctors many times with flu like, systems and breathing problems with chest pains. After stopping this medication after being on it for months, it has now been a week, my breathing still has not returned to normal as of yet. PLEASE if you have any flu like symptoms, breathing problems, or even seem to just have a change in your voice, stop taking this medicine and see your doctor."

1 / 10
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  • Dt192...
  • Taken for 1 to 6 months
  • March 19, 2017

Amitiza (lubiprostone) for Irritable Bowel Syndrome with Constipation "I'm a 25 year old woman who has struggled with IBS-C for about 5 years now. I started off taking linzess but it was too strong and I would just have to run to the bathroom every 15 minutes for hours. So my doctor put me on the 8 mg dose of amitiza and my life has changed for the better. It still takes me an hour to go to the bathroom in the morning but I'm not waiting to go anymore. The medication works. I take it before bed and 2 hours before I wake up to give it a chance to work in my body and then drink a glass or 2 of water to kickstart it when I get up. And I don't have to worry about constipation anymore. I've been on it for 4 months and I love Amitiza."

8 / 10
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  • antwan
  • Taken for 1 to 6 months
  • March 19, 2017

Amitiza (lubiprostone) for Opioid-Induced Constipation "I am a recovering heroin addict and have been taking suboxone in low-medium amounts to control withdrawal sympts & cravings, as I was not able to stay clean on my own due to underlying depression, schizophrenia, ptsd, and others. I have been clean for over 3 years and have had crippling constipation since on the suboxone. My Dr prescribed me amitiza, but told me to only take it as needed. I did experience nausea and stomach cramps at first, but now do okay with it, and have had much better BMs. "

6 / 10
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  • 62...
  • Taken for less than 1 month
  • December 17, 2016

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "After reading all the previous reviews of Amitiza I felt compelled to add my experience. The first morning I took it with a meal and plenty of water and went to work. Mistake! Jeff Foxworthy jokes about the side effects of certain medications, like fecal incontinence. I can assure you it's no laughing matter when it happens to you. Within 1 1/2 hrs. it began. My stomach was full of gas, and I was worried sick all day about not knowing when my issue would start. That evening I took my second dose and about three hours later had leakage on my sheets. I had just been diagnosed with hypothyroidism and was put on Synthroid. The combination of my age, Synthroid and Amititiza=fecal incontinence according to the "eHealthMe" website."

2 / 10
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  • Cosmi...
  • Taken for 1 to 6 months
  • August 3, 2012

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "If you suffer with occasional constipation like me and you suffer from irritable bowel syndrome then this is a great medication. It is very safe with very little side effects that most women will already go through. Like headaches and random nausea and dizziness. I take this medication 2-3 pills twice a day and I feel so much better being on this medication. It isn't normal to go a day or two or three or even a week like what used to happen to me without having a bowel movement. This medication will help you release all that waste you need to. It works great for me. IBS is not a fun condition but I guess it's just for all of us lucky people to struggle with and experiment trial and error. Give Amitiza a try it really works. Good luck!"

9 / 10
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  • Quality...
  • January 6, 2013

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "45 year old female with diagnosis of Chronic Constipation due to long term use of Med's, to include opioids for pain management. Also, diagnosed of Irritable bowel syndrome, around 8 years ago. When I'm taking this medicine, usually 2-3 times per day, I'm regular with a bowel movement of one to two times a day, depending on my diet and food intake (I eat very little on most days). Whenever I'm not taking this medication, I'm lucky if I'm able to go once over a 3-4 day time frame, even with laxatives, stool softeners, and my daily dose of lactulose syrup. I took Zelnorm about #8 years ago, until it went off the market, but Amitiza works much better, I asked my doctor to prescribe it after seeing a commercial for it, I've done well with it, only side-effect: flatulence. "

10 / 10
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  • Nicole...
  • Taken for less than 1 month
  • February 18, 2016

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "Well I started this medicine on Monday and its Thursday and I am extremely sick. My stomach is killing me I sit on the toilet because I feel like I am going to go to the bathroom but nothing ever comes out. I have severe abdominal cramping and cold chills that make it even worse. My chest feels tight and I am so uncomfortable and grouchy because of the pain. This is awful I would not recommend because I was so excited about being able to go to the bathroom and be normal but this has not worked. I am not taking any more of this medication when it is suppose to help with chronic idiopathic constipation and IBS and its made it worse!! So upset I could scream..."

1 / 10
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  • Autumn
  • December 17, 2019

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "I started taking amitiza when I was around 16-17. I was on it for about 2 years. I had tried a lot of drugs before my pediatric doctor finally landed on this one. My family and I were hesitant to try it because of how expensive it was, but we felt like we were out of options. It was the first med that actually worked other than stimulant laxatives. I remained on the highest dose of amitiza during my time on it. I had no side effects. I eventually stopped taking it because the medicine began to stop working. It was basically a gradual decline of efficiency near the end. I don't regret taking it even though it stopped working. I switched to linzess and its working just as well. If linzess stops working, my plan is to switch back to amitiza and see if it'll work again. If you're considering trying amitiza, I would. Just make sure you try it on your day off if you're worried about side effects"

7 / 10
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  • coach
  • May 11, 2017

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "55 yr old female, chronic constipation my whole life. I have tried everything, OTC to Linzess which did nothing. I am thin, exercise, high fiber, flax, metamucil, probiotic, and nothing. I go 4-5 days then take 3 ducolax, magnesium citrate and pray. Now that doesn't work. Colonoscopy ruled out anything "serious". Prescribed 24mcg Amitiza. Ate breakfast took the pill and within an hour I was SO SICK. I had explosive diarrhea, felt faint, nauseous, cold chills and sweating. Laying on my bathroom floor going back and forth to the toilet, thought I would throw up too. But I went! I did not take it again because of the side effects. Doc gave me 8mcg. I'm scared to take it. It's awful that I would even think of taking it again just to go to the bathroom"

4 / 10
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  • Tummy...
  • Taken for less than 1 month
  • September 13, 2019

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "Oh my no no no! Avoid this. I took one 24mg pill with food. 30 mins later felt lightheaded and drenched in sweat. Vomited all over the floor. Couldn’t even make it to the bathroom and more vomit hit. Then the horrible loose stool started. So loose you can’t get off the toliet or you’ll have a mess. Finally took a zofran to ease the vomiting. I feel so much worse. Not worth it! Avoid this Med. I feel like death"

1 / 10
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  • milli...
  • Taken for 1 to 2 years
  • January 19, 2019

Amitiza (lubiprostone) for Opioid-Induced Constipation "Amitiza has helped me tremendously with my gastro issues. My cost is pretty high even with insurance which makes it very difficult every month to refill but i faithfully take it as prescribed; Amitiza, for me, is a LIFESAVER!!!!!!"

10 / 10
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  • mommy
  • Taken for less than 1 month
  • August 3, 2018

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "For the past 2 years Ive been struggling with constipation since going through chemo. I finally got referred to see gastroenologist. He put me on a low dose. 8mg twice a day and I can say for me personally I feel like a normal person again!! This is the best medication no side effects so far other than having to go to the bathroom a few times a day. I've tried drinking more water, having more fiber other laxatives and even linzess which was a no after the first pill. Not having the bloat feeling and feeling like you have to struggle to go the bathroom is the worst."

10 / 10
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  • Angels
  • May 16, 2017

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "I have been using amitza for a week. You need to take this LITERALLY WITH FOOD. If you have eaten lets say an hour before, do not take it. It will cause you severe painful stomach type of nausea. I feel after taking this. It causes me some type of stomach cramps. Not severely painful that will cause you to curl up in a fetal position but uncomfortable enough that you know its there the weird feeling in your stomach area. I have called my doctor to see if its even worth one more week to try despite the side effects. I have not seen any improvement in my bowel movement."

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  • LYBL
  • Taken for less than 1 month
  • November 5, 2016

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "I am in my early 60s. Have had chronic constipation ever since childhood (2 BMs per week), but it became much worse in the last couple of years (up to 2 weeks without BM). After more than a year of trying to find the optimal amount of Miralax to take per day per GI doctor's instructions, and when to also include stool softeners, I was doing okay (BM every 4 or 5 days), but had occasional leakage. I started Amitiza two weeks ago at my internist's suggestion, two 8mg pills twice a day. It was like a miracle the first week - small to medium daily movements and a couple of large ones. No side effects. But now it stopped working. It has been 7 days with no BM. The last 2 days I took 24 mg. Also ate prunes and took stool softeners. Nothing yet."

6 / 10
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  • Ms...
  • September 19, 2011

Amitiza (lubiprostone) for Chronic Idiopathic Constipation "I've been chronically constipated since I was 5 (I'm in my early 20's now). I always went to Doctors, who kept saying over and over "fiber and water." Prune juice and normal laxatives (not stimulant laxatives) would have little to no effect on me. Amitiza makes me feel normal, and for the first time I can ever remember, I don't dread when I have to do a bowel movement. It's painless! I've solved this taboo problem that I have suffered with for my entire life! Its a great feeling to have relief now. I do get nausea and a headache if I take it without a moderate sized meal. I also get cramps and explosive diarrhea if I take it and then eat a lot of dairy, like a milkshake (I'm not lactose intolerant though). Despite this, I love this medicine!"

9 / 10
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  • Irma...
  • September 14, 2011

Amitiza (lubiprostone) for Irritable Bowel Syndrome with Constipation "For over twenty years I've had issues with my stomach. Mainly constipation in spite of drinking plenty of water and high fiber diet. I've relied on eating five servings of fruits and three veggies a day and of course lots of liquids. I've been seen by lots of specialists until recently I was prescribed Amitiza 8mg. I tried it for two weeks then tried the 24mg as instructed by my doctor and found that the lower dose works better. I'm able to defecate at least once a day now, but I have experienced headache nausea and slight dizziness. Overall I do recommend it."

10 / 10
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  • Tee1h...
  • November 17, 2015

Amitiza (lubiprostone) for Irritable Bowel Syndrome with Constipation "I have had problems with IBS for several years I was on Amitiza and one of my physicians took me off it I was off for 5 years started having severe problems with my IBS again my new doctor GI doctor put me back on it and it is a God sent I am back regular again I give this medicine at 10 I have no side effects and I love it thank you"

10 / 10
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  • Anonymous
  • February 23, 2011

Amitiza (lubiprostone) for Irritable Bowel Syndrome with Constipation "I absolutely love this medication! The trick I have found is to take it right before bed, then you can avoid the upset stomach and nausea. I know it says to take with food but I have been on this for over a year and it has been working great for me."

10 / 10
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  • IBS...
  • Taken for 1 to 6 months
  • April 17, 2014

Amitiza (lubiprostone) for Irritable Bowel Syndrome with Constipation "I have tried amitiza and yes it worked and got me to use the bathroom but didn't do very much for my stomach pain. I did get some relief just from going. I also had to take way over recomended dose to get anything significant. "

5 / 10
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  • Keke
  • September 23, 2011

Amitiza (lubiprostone) for Irritable Bowel Syndrome with Constipation "In the beginning, I was very skeptical about taking this medicine because most of the reviews I read were negative. Now, I honestly love it. The first week was a little rough due to the shortness of breath as well as the gasiness. Then I realized almost every medicine has some type of side effect until your body gets used to it after a few days or so. By the second week, I was fine. Before taking Amitiza I only had bowel movements every 4 or 5 days and sometimes it would take a week and I also had pains in my abdomen. But now I am going regularly and I feel much better about it. The only negative I have is that my insurance won't cover Amitiza."

9 / 10
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45 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.