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Leuprolide User Reviews & Ratings (Page 3)

Brand names: Lupron, Eligard, Lupron Depot, Lupron Depot-PED, Fensolvi, Camcevi

Leuprolide has an average rating of 5.6 out of 10 from a total of 360 reviews on Drugs.com. 42% of reviewers reported a positive experience, while 36% reported a negative experience.

Reviews for Leuprolide

  • I...
  • August 19, 2016

Lupron Depot (leuprolide) for Uterine Fibroids "I have been on lupron for 3 years. I began the shot in 2013 with a 11 cm fibroid too large for surgery at time. I am now in my late 50's and still testing positive on hormon tests. another words if I go off lupron I a assuming the fibroid will grow again and I will begin again to menstruated and have heavy bleed and large clots. my headaches became much less and only have hotflashes towards the end of my 3 month shot. I get shots quarterly. my bone density was just shy from normal with no concerns for many years. I take calcium, D3 and K2 (MK7-helps make calcium go to bone not soft tissue like calcification and bone spurs ). for me is has been the best thing in my life. I can't imagine why people have bad results. oh and no weight gain."

10 / 10
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  • illini
  • Taken for 6 months to 1 year
  • October 30, 2019

Eligard (leuprolide) for Prostate Cancer "Received an 6-month injection of Eliguard. Approaching 8 months since injection and I am still having several HOT FLASHES every day and night. Unfortunately, there is not a remedy that will bring an end to the episodes."

2 / 10
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  • Nishp...
  • August 5, 2016

Lupron (leuprolide) for Prostate Cancer "Diagnosed Stage 4 Prostate cancer-- July 2012--PSA=8 Radical Prostatectomy-- October 2012--PSA=0.6 Forty days radiation--April 2013---PSA=0.1 PSA=0.3---Jan 2015 PSA=1.0---March 2015 First Lupron Injection---April 2015--PSA=0.1 Second Lupron Injection--Oct 2015---PSA=0.1 Third Lupron Injection---April 2016---PSA=0.1 Fourth Lupron Injection---Oct. 2016--PSA=??? Lupron Injections accompanied by daily tablets of Bicalutamide. Side Effects: Penis shrinkage(afraid it will soon disappear), libido absent, hot flashes, some insomnia, increased neuropathy, some itching, inflammation in hands, extreme fatigue. All side effects manageable--beats being dead-- and has allowed me time to tie up loose ends and who knows--I may have years ahead!"

8 / 10
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Frequently asked questions

  • Anonymous
  • Taken for 1 to 6 months
  • August 26, 2019

Lupron Depot (leuprolide) for Uterine Fibroids "I got my first Lupron shot on 07/22/2019 for fibroids. My obgyn decided to put me on Lupron to attempt to shrink my fibroids/Uterus so I can have a safe hysterectomy. I haven't had a menstrual cycle since 07/22/2019 that's awesome. So far I am experiencing: first week my buttock was very sore/tender from the injection site. I am experiencing a lot hot flashes through out the day and at night they last a few minutes. No night sweats. My body, but mainly my legs ache and feel tingly/numb. Restless nights, having trouble staying asleep. My hair is now very dry and brittle and hair loss. (It was healthy before). Vaginal dryness. Memory problems, trouble focusing. I am forgetting a lot of things. Major mood swings, from very angry to crying. Increased appetite (carb craving). I hope all this is worth it at the end. None of these side effects are unbearable but I definitely do not feel myself. Round 2 coming up 10/22/2019."

6 / 10
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  • Anonymous
  • April 10, 2011

Lupron (leuprolide) for Uterine Fibroids "Side effects experienced from 3-month shot: hot flashes, night sweats, fatigue, cognitive "fuzziness", decreased memory. I experienced a significant temporary reduction in fibroid size/abdomen size (pre-surgery)."

8 / 10
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Are you taking this medicine?

  • tuppy
  • August 30, 2016

Lupron (leuprolide) for Prostate Cancer "I AM 87 AND HAVE BEEN TREATED WITH LUPRON FOR ABOUT 6 YEARS. I JUST HAD A CHECKUP AND MY PSA LEVEL WAS .430, MY LAST SHOT WAS IN APRIL. It is hard to tell when i will have another shot, i will check in with my doctor in four months, So far the only side effect is the hot flushing. It is fairly regular, last about 45 seconds or so and is a bit annoying, but considering it is keeping the cancer at bay i can live with it,"

10 / 10
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  • albert...
  • Taken for 1 to 6 months
  • May 7, 2016

Lupron (leuprolide) for Prostate Cancer "This is pure poison, I have very bad side effects from this poison and the doctor said he can do nothing, the physical and mental pain is so bad , hot flashes, very high blood pressure, head aches every day, pain urinating, joint pain, mental confusion , brain fog, memory loss, total itchy all over, sleeplessness , very bad fatigued, and a lot more, my doctor never told me anything about this poison just injected my with a 6 month supply, at 6,000.00."

1 / 10
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More FAQ

  • amaya
  • Taken for 1 to 6 months
  • November 19, 2012

Lupron Depot (leuprolide) for Endometriosis "I started Lupron about a month ago. I started taking it after the doctor told me I had stage 1 endometriosis. About a year before I found out I had PCOS which caused me to gain a lot of weight, about 23lbs. Since I've been on Lupron I've been feeling so much better and I've LOST 7LBS!! The only thing I have been struggling with is the hot flashes. other than that I've been doing very well on the shot."

10 / 10
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  • Marcus
  • Taken for 1 to 2 years
  • October 28, 2019

Lupron Depot (leuprolide) for Prostate Cancer "On lupron beginning July 2017. Now 2019 and still on 3 month dose. I experience all the known side affects and it is not much fun. I am 66 years old and have advanced prostate cancer stage 3. My PSA undetectable since surgery and 40 radiation treatments. Hot flashes, weight gain, fatigue, tingle in feet, itching, impotence and bone aches. PSA is still undetectable...going off lupron in May 2020...we will see what happens then."

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  • LJonesL
  • December 15, 2014

Lupron Depot (leuprolide) for Endometriosis "I was diagnosed with Stage 4 endometriosis and was prescribed Lupron. After reading all of the horrible reviews and side effects I was terrified to try this. After chatting with my doctor we both agreed that this would be the most aggressive treatment as my husband and I would like to get pregnant one day. I am on month 3 of the shot and I have to say that I am pleased. The worst thing are the hot flashes. For me they are at least 10 times a day! But I will take that over the excessive cramping and pain any day. I feel minor cramps occasionally during the time I would normally have my period. I have experienced no depression, weight gain, weight loss, bleeding, joint pain etc. I am hoping after the treatments I will be able to conceive."

7 / 10
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  • Patient...
  • July 24, 2021

Eligard (leuprolide) for Prostate Cancer "I just got my 3rd shot of Eligard. Hard to say exact side effects, because I also have end stage COPD. I haven't got a PSA yet, prior to Eligard, it was 7, then 17, then 24. Due to Covid...I put off seeing an Oncologist for 7 months. I got both Moderna vacs in March...I started Radiation in April and finished on June 9. It seems each shot of Eligard is getting a bit worse. This last one hurt and burned longer.. a minor issue. Hot Flashes seem more frequent. I too go to bathroom about 9 or 10 times a nite...every 1 to 1.5 hours, but that was happening before Eligard. I am dizzy a lot...and I don't have much energy (I used to be quite active). I am 66 years old. My cancer rated as Stage 3...there were tumors on 8 of 12 biopsy samples. Surgery wasn't an option since scans showed it may have spread to lymph nodes. I will update this (if possible) with my PSA score this September. Good luck to everyone. I can't recommend Eligard or condemn it as of this writing."

5 / 10
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  • nelofar
  • June 19, 2017

Lupron Depot (leuprolide) for Uterine Fibroids "I had my heavy period and strong and constant pain which stops me doing my normal life for more than 5 years. Since I have started to inject this Lupron it has changed my life after all those painful years now I had 4 injections already and go for the fifth one. The only side effect I had is hot flashes especially during nights and some bone pain which are nothing to compare with the pain I had for more than 5 years. It is really worth to try if you are on the heavy bleeding and pain."

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  • Jazzy...
  • Taken for 2 to 5 years
  • December 1, 2012

Lupron Depot-PED (leuprolide) for Precocious Puberty "My 8 yr old daughter had signs of CPP; breast buds, armpit odor, excessive height. After seeing the specialist and getting test the ultrasound said she developed 5 cyst on her ovaries. The hand x-ray said she had a bone age of 10. She started the monthly Lupron shot. She is now 10 and she has no cyst on her ovaries now. Yet her bone age shows 12. Her breast buds are completely gone. She never gained any excess weight. No night sweats. We plan to stop the shot right after her 11th birthday."

7 / 10
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  • Endo...
  • Taken for 1 to 6 months
  • September 24, 2014

Lupron Depot (leuprolide) for Endometriosis "Stage 4 endometriosis. I've been on Lupron for 3 months and will get another injection next week. I've had a few hot flashes, about 1x/day occasionally, but not everyday. I have stayed below my original weight by about 5lb. Some moodiness/occasional depression. But overall I haven't had any major problems! I was very worried about side effects before starting Lupron, but am glad I did it. I want to be healthy! I'm getting married next weekend also so have been planning a wedding at the same time. We're hoping to get pregnant next year!"

10 / 10
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  • Anonymous
  • January 3, 2010

Eligard (leuprolide) for Prostate Cancer "I was given two injections of Elgard before beginning radiation therapy. Following the 48 radiation treatments, I am still being monitored by my oncologist and urologist. My last PSA was 0.01. The side effects of hot flashes, lethargy, and muscle weakness are where I am today, although at my age, 79, I can't complain. The first of the injections was in April of 2008 and the second in August. Radiation began in early September 2008 and ended at end of October. It was determined that I am not a candidate for Androgel as there is a possibility of developing cancer again. So, as you read from the preceding paragraph, I'm lucky to have passed my first year without problems."

6 / 10
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  • AnnaR
  • Taken for 6 months to 1 year
  • May 31, 2015

Lupron Depot (leuprolide) for Uterine Fibroids "I had extremely painful periods and constant bleeding. My doctor started me on the shot in Jan. and had second one in March. Best thing I ever did. No bleeding after 1st month and no pain after the 2nd month. Side effects were in my opinion mild. Worst were the hot flashes but in my opinion worth it. Doctor only wanted me to have to 2 shots so after June going to see what happens. I don't want to get on any birth control so will see what happens. I'm really hoping this makes it all better."

10 / 10
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  • seven...
  • February 8, 2019

Lupron Depot (leuprolide) for Prostate Cancer "My father has prostate cancer and he was given the Lupron shot. Everything was going fine for my dad until 2 weeks after the shot. He started having side effects from the shot. Now before I go any further let me just say if anyone has PTSD do not take this drug. My father started seeing things that were not there, hearing things that no else could hear, and smelling things that no one else could smell. Now not everyone will have the same side effects, but if you have PTSD it will kick it into gear.This might be the right treatment for you, it is not for my dad. Again if you struggle with PTSD this may not be the treatment for you. I hope this was helpful in some way. "

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  • cdawhg
  • November 13, 2015

Lupron Depot (leuprolide) for Endometriosis "I really feel it is important to share my experience with this drug. I did extensive research before making my decision to start the Lupeneta pack. I was scared and I prayed to have a good experience since most reviews for this drug are aweful. I am grateful to be able to give this drug TWO THUMBS UP! I am taking one month shots combined with the add back pills. The first month I experienced NO increase in symptoms. I bleed for the first month and a half, now my constant bleeding is gone! For the first month I experienced very mild hot flashes, now none at all. My quality of life is 110% better and I am pain free. I am so grateful i took a chance on this medication. I finally got a break from the constant pain and exhaustion from endo."

10 / 10
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  • 1Sweet
  • Taken for less than 1 month
  • January 29, 2014

Lupron Depot (leuprolide) for Endometriosis "I was on Lupron for 6 months back in 09. The side effect weren't bad for me at first but I have to say the night sweats were the worst! I just hated waking up in the middle of the night, needing to shower because I was so sweaty. However, I was pain free! I had an AWESOME summer and went camping, mountain biking, traveling. My pain has slowly come back over the years and my (new) doctor just gave me my first shot of Lupron yesterday. I am hoping it works just as well as it did the first time. I want to be me again."

7 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • July 15, 2012

Lupron Depot (leuprolide) for Uterine Fibroids "I had to get the 3 month Lupron Depot shot to help shrink my uterine fibroid and to help minimize the bleeding before surgery. After reading all the reviews on the shot I was very scared to get it but I am now going into my third month on the shot with minimal side effects. My doctor did recommend that I continue my birth control pills while on the shot to help add a little estrogen back into my system. I'm not sure if that's what help me with the side effects. All in all everyone's body reacts differently."

9 / 10
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  • MoMoMo
  • Taken for 1 to 6 months
  • May 6, 2020

Lupron Depot (leuprolide) for Endometriosis "I was put on lupron depot for three months for endometriosis. I received an injection every month. My treatment started in January and ended the first Saturday in March 2020. The side effects weren't all that bad. I got my period on my dose but it eventually went after that. I had however severe headaches that made me dizzy, experienced some mood changes (mostly anger), painless sex, hot flashes (manageable) and joint pains at the end of my last shot. The joint pains are mostly in my knees and fingers but i only experience those after waking from a nap. Once I get up and start moving about they disappear. I now await my cycle to return. It has been 8 eight weeks since my last injection and signs of my period returning are back. I'm spotting and experiencing mild cramps. All in all my experience wasn't bad. Hope this helped someone oxoxox"

8 / 10
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  • Grumbly
  • September 30, 2016

Lupron (leuprolide) for Prostate Cancer "My PSA was rising after RP to 0.59. Started radiation with Lupron. If you exercise really hard with lots of caffiene, no sugar in the morning and minimal sugar all day long with high quality food, then the effects of Lupron are minimal other than the muscle pain and some joint pain. Sex life is about once a month. The more you exercise, the more likely you are able to have a sex life. After six months on Lupron I can still have sex. I took Bicalutimide with my first shot. I highly recommend to avoid the hot flashes"

6 / 10
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  • Jerry
  • Taken for 6 months to 1 year
  • April 30, 2023

Eligard (leuprolide) for Prostate Cancer "I have had my second dose of Eligard 45 mg, 6 months apart. Radiology convinced me I should do this to prevent the recurrence of cancer. I had a Grade 4, contained to the prostate. Had 28 radiation treatments. My PSA now is at zero. I have told the doctors I "will not" take any more hormone injections. My life has been ruined. I am turning 76, but been an active walker, biker, lifted weights, etc. all my life. Now I have intense bone pain all over my body, my muscles are half what they were, and I have hot flashes all day and night. I force myself to exercise, but life is now hell. I get depressed and emotional. Wish I had never taken the first injection. Not sure if my body will ever recover. The doctors need to educate their patients with proper data and let them make a choice."

1 / 10
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  • Lexii
  • October 5, 2015

Lupron Depot (leuprolide) for Endometriosis "Don't do it! I got the 3 month shot 1 month ago and have had these symptoms so far: constant and severe pelvic pain, sharp lower back pain, pain when bladder is full and when emptying, lots of migraines & headaches, nausea, vomiting, high anxiety, extreme fatigue, very low mood swings, loss of appetite and insomnia. The worst symptom of all is the severe depression, I have had several thoughts of suicide. I would rather deal with just the pain than all of these together. I was told by my doctor the only symptom I would get is hot flashes and she had only heard of success stories with this drug, that was a total lie. If you react badly with other birth controls do not do Lupron, it's a living nightmare!"

1 / 10
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  • Not...
  • Taken for 1 to 6 months
  • January 22, 2015

Lupron Depot (leuprolide) for Endometriosis "I am 37 and for the most part been very healthy...never pregnant and married for three years. I have had ovarian cyst, but have been controllable. Nov.9, 2014 I went to the ER and the next day I was having a mass and 6" of my colon removed due to Endometriosis. I had stage 4. My OBGYN suggested this shot. I read all the reviews and was VERY learey of starting it, but I just took my second shot. It has not been so bad. I have experienced hot flashes and weight gain. I have about 4-6 hot flashes a night, but no sweats yet. I am hungry ALL the time and it seems the more I eat, the more I want. I cant seem to get full. I have gained 10 pounds in about 6 weeks.My mood has been good though. I have had to start Osphena due to side effects."

10 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.