The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
I am hearted by the 6 reviews. I have just started on Deplin. I have been on Remeron for two years. I cannot tolerate serotonin type medicines such as Prozac, Lexapro. Remeron worked beautifully at first but effects have slowly worn off and my anxiety and mild depression returned. I pray Deplin will work for me and I can regain my enthusiasm and joy in life. I am happy for those of you who have been helped. Wish me luck.
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I have had partial response to my antidepressant. I have had a hard time finding one as my chemistry responds unfavorably to many drugs. Deplin was advised by my Doctor who has actually participated in clinical trials. She had seen no adverse effects and thought it would work great for me. On 3rd day I felt like my old self for first time in 1 year. Unfortunately, that night I had auditory hallucinations... first time in my life... and a very restless night. Went off and slept okay. Tried just doing folic acid and Vitamin B6 and had the same response, only worse. Didn't sleep the whole night. Both my Psychiatrist and Psychologist say I am the only person who they have ever seen have a negative reaction. Like I said, I felt great. Good luck.
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No side effects, many more plus/up days than before. Seems the longer I am on the Deplin in conjunction with my antidepressant, the better my moods and overall feeling gets.
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I've been on Deplin for 20 days now, along with Zoloft. I had great success with Cymbalta, but it messed badly with my blood pressure (going from 112/65 to 175/100) so I had to go off it. I was put on Zoloft as a stop gap, but have tried it in the past without much success, as with all the others. They say it can take 4-6 weeks before Deplin has its full effect. I'm still hopeful, but I do so wish I'd seen the overnight change like others.
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I have been depressed since 1998, after I had a fall at work, and with problems with the work doctors. My doctor had me try different types of medications, like Prozac, Wellbutrin, Paxil,and Tofranil. Finally the one that helped me was Effexor. At least I thought so. Then the Doctor put me on Deplin and I felt like I hadn't felt in a very long time. That was 8 weeks ago and now I feel great. Deplin has really changed my life. Thank you for letting me share this with you.
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I'm 47 and have had serious, treatment resistant depression since my early 20s. Antidepressants have offered me some relief, though it has been far from complete. Although I have remained consistently on antidepressants since Prozac was released, my depression has been bad. I've been muddling along on Pristiq and Welbutrin. Recently my doctor had me on Ritalin as well, to give me the energy just to make it through the day.
She put me on Deplin a week ago and its effect on me was felt the next day. After a night of extremely colorful dreams, I woke up feeling great. I took my medicine as usual and it was suddenly as if my brain could feel all the antidepressants for the first time. I spent a trippy weekend, got in touch with my doctor on Monday, immediately discontinued Ritalin. I'm still feeling great, full of energy, and still feeling over medicated. I suspect the next step might be to reduce, if not discontinue, the Pristiq and Welbutrin.
This is the first time I've ever actually thought I may have found a "cure" for lifelong depression. It's only been about a week now, but I remain cautiously optimistic.
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stingaling said: 
