User Reviews for L-methylfolate
Also known as: Deplin, Duleek-DP, L-Methylfolate Formula, Vilofane-DP, Zervalx
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Learn more about L-methylfolate.
|Folic Acid Deficiency||4 reviews||7 medications|
|Depression||46 reviews||75 medications|
|Borderline Personality Disorder||2 reviews||6 medications|
|Hyperhomocysteinemia||0 reviews||59 medications||Not rated - Be the first|
|Summary of L-methylfolate reviews||52 reviews||8.5|
Reviews for L-methylfolate
Review by Male, 46 yrs old (taken for 1 to 2 years):
For Depression: Depression sufferer my whole life. On Deplin for last year and my lows vanished within first week on 15mg/day. It's all I'm taking and the benefit is absolutely profound. Zero side effects. Most psychiatrists downplay the lack of studies but it definitely works for me better than anything else I've tried. Good luck.
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February 15, 2015 11:46 AM
Review by Anxious like crazy (taken for less than 1 month):
Deplin (l-methylfolate) for Depression: I have been taking Citalopram and Clonazepam (for panic attack only) for MONTHS. My anxiety level, even on these medicines, was completely out of control. To the point where my muscles were twitching non stop all day long (as well as other physical symptoms). I added the Deplin to my 20mg Citalopram at the request of my doctor. Within a few days I felt like a completely new person! Better than I have felt in years. My muscle twitching completely went away and I no longer have obsessive thoughts. I highly recommend this medicine for anyone suffering with severe anxiety or Generalized Anxiety Disorder. It is life changer. Well worth the $60 a month.
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January 16, 2015 8:56 AM
Review by JDmom2four (taken for 1 to 6 months):
For Depression: After YEARS of depression & anxiety I'd been on countless combinations of medicines. The past few years severe health problems (open heart surgery @ 37 and a bowel resection @ 39 over 200 days in hospital) have contributed to the lowest lows of my life. I've spent the vast majority of the past two years in pajamas. EVERYTHING felt overwhelming. Living a normal life again seemed impossible. I had absolutely NO energy & believed I'd feel tired forever which made me sad all the time. After adding Deplin to the Celexa I've been taking for years, I am amazed by the results. It's been like flipping a switch in my brain. The darkness has been flooded with light. I have the motivation to live life again. Deplin is nothing short of a miracle!
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January 12, 2015 10:40 AM
Review by ktexas:
Deplin (l-methylfolate) for Depression: For the past several years I have been trying to find the right balance to deal with the anxiety and depression of Post Traumatic Stress Disorder. I have been on Citalopram for the depression and that seems to work well. It has been hard to find an antipsychotic that works and currently I'm on Latuda. I'm also on a mood stabilizer Lamictal. My Dr added Deplin. Long story I wound up without my Latuda and Deplin for about 6 weeks. In 6 weeks I was off the charts on the ups and my old patterns were popping up. Not good. I went back on the Latuda and began evening out but still had too much up. Now I've been back on the Deplin for a week and I feel completely numb. Trouble sleeping at the right times, trouble being awake or at least alert at the right times.
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October 27, 2014 12:59 PM
Review by Danforth (taken for 1 to 6 months):
For Depression: So we are still learning about methylfolate and its effects in depression as it's still pretty new (megavitamin) and we're still learning about the role genetics play in the methylation cycle. I noticed a boost after a week on 15mg then it disappeared. I kept taking even though it wasn't really working anymore. Then after about six weeks I got a huge boost and as I was also on Wellbutrin at the time, it was actually way too much serotonin in my system. I think some people need doses much lower than the prescription strength and it can take a while for the full effect to kick in. It can take a little while to get back to a healthy level but it can definitely help boost whatever else you're on. Look out for hypomania if you're bipolar.
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October 24, 2014 1:23 PM
Review by John_Deaux:
For Depression: I'm 47 and heterozygous for both MTHFR mutations. I just came out of a deep, dark depression with the help of Effexor. I started taking 0.5 milligrams of methyl folate (yes, a very low dose) about a month ago. Even this small amount of methyl folate (in combo with methyl B12) affects me deeply and immediately. I take it before 8 in the morning, and it still influences my sleep that night. I have never been an active dreamer, but on methyl folate, I dream A LOT. I seem to feel more awake and active in the afternoons, as well. I agree with the commenter about being on methyl folate for a period of time before deciding if it works for you. You may feel the effects immediately, or later on. There may be ups and downs.
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October 16, 2014 5:46 PM
Review by Ellablue1:
Deplin (l-methylfolate) for Depression: I was so very excited when I found out that I could be helped after being diagnosed with MTHFR, I was on Deplin 15mg a day, I actually felt fantastic after about 2 months of treatment, after about 8 months I slowly started getting severe muscle pain and weakness also extreme joint pain as to where I could barely work or do the slightest of activities. Doctors ran a ton of blood tests but found nothing, I recently stopped taking Deplin and have found that the issues have disappeared! I loved Deplin and am very sad I can't take it any longer! It really also helps with depression and mood!
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August 25, 2014 5:48 AM
Review by Spectatrix (taken for 1 to 2 years):
Deplin (l-methylfolate) for Depression: This is a great add-on medication for depression. I am compound heterozygous for the C677T and A1298C MTHFR mutations. I was taking Celexa and Wellbutrin and still having frequent depressive episodes when I first started taking the Deplin. After about a month on Deplin, I weaned off the Wellbutrin. We later lowered my dosage of Celexa too. I did try to wean off Celexa completely and use Deplin as mono-therapy, but ran into issues. I've been taking Celexa 20mg and Deplin 15mg for over a year now and it's still working great!
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August 20, 2014 5:03 PM
Review by Jennifried (taken for less than 1 month):
Deplin (l-methylfolate) for Depression: Added Deplin 15mg to 150 mg dose of Wellbutrin when the Wellbutrin no longer worked as well. It did help for a few days but then I developed severe muscle weakness, stiffness and pain particularly in my neck and shoulders. Bad enough that I could not turn my head or look up or down without great discomfort. Kind of felt like I had whiplash. I did some research and found that the muscle pain can be a side effect of both medications. I have not ever had this problem on Wellbutrin alone, so I'm inclined to think the Deplin caused this. I quit taking both medications because I couldn't function with the pain and stiffness any longer and 2 days later the pain is still there but is slowly subsiding.
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August 4, 2014 6:24 PM
Review by Aging Backwards (taken for less than 1 month):
Deplin (l-methylfolate) for : I finished the 6 day trial, and I must say I felt so good on the last 2-3 days on Deplin. I didn't experience the crazy lows I had in the last few months. I don't truly have depression, more like bipolar 2, and on no medications. I love my emotions, and want to work with them, so my naturopath suggested we try Deplin. I will be seeing her again next week, and I will ask her to continue it.
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May 20, 2014 11:41 AM
Review by ladykatlee:
For Depression: Wow. Where to even start. I've been on several cocktails of antidepressants from ago 13-28. Finally, my doctor prescribed Methylfolate in conjuction with Celexa. Within 10 days, I felt more alive, motivated, energetic, and at peace then I had EVER felt in my life. Absolutely a miracle. If you have given up on the endless trial and error, please, please give this a chance.
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May 2, 2014 1:58 PM
Review by just a guy:
Deplin (l-methylfolate) for Depression: I thought I would share my experience as it may be helpful to others. I have been on this for over 2 years now... and depression wise (which is what I'm basing my rating off of because that is what this rating is supposed to pertain to) it hasn't done anything for me at all. At least nothing at all that I have ever noticed. I have stayed on the medication because of the fact IT DOES help bring down my homosistine levels. I have a condition referred to as MTHFR. Basically it's a liver enzyme condition that makes it so the body doesn't convert proteins/peptides very well. Common condition (1/10 americans) but rarely tested for. The lab had to look up what to do for drawing blood and testing for it.
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March 26, 2014 4:38 AM
Review by jjojjo (taken for 5 to 10 years):
Deplin (l-methylfolate) for Folic Acid Deficiency: Has changed my life, both physical autoimmune, genetic, hormonal disorders have improved and mental health PTSD, ADHD, RBD-Dyslexia have improved. I wish I had known about my mutation in child bearing years as I lost five pregnancies. My only daughter was the one I had morning sickness with and didn't take prenatal multivitamins.
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March 9, 2014 4:09 PM
Review by Frenchiemagoo:
For Depression: I have suffered with some depression but mostly anxiety for the past 15 years. I have taken Celexa and then Lexapro off and on (mainly on) for most of those years. While the Lexapro helps some, I still always had difficulty with my energy levels and with coping during really stressful situations. I was recently tested for MTHFR gene mutation, and was found to have the 1298c mutation, which can affect my brain's ability to utilize folate in order to make needed serotonin, dopamine, and norepinephrine. My doctor prescribed Deplin (l-methylfolate), and even though I had read many good reviews, I was still hesitant. I have to say it has been a miracle for me. It's like this dark cloud has been lifted, and my anxiety has completely disappeared.
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February 8, 2014 1:23 PM
Review by ladyKR:
Deplin (l-methylfolate) for Depression: In 28 years, after dozens of antidepressants, add on's, ECT's...I've never felt so full of life. Ever. An absolute miracle this was. I was absolutely lifeless. I feel sorrow for having gone so long miserable, but blessed to have been lucky enough to have a doctor try this with me.
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December 14, 2013 10:22 AM
Review by whizbang1111 (taken for less than 1 month):
Deplin (l-methylfolate) for Depression: I have been taking Deplin for 18 days and I do notice a slight change in my depression/brain fog and energy levels. I think it is being inhibited by my Adderall withdrawal but am hoping it is helpful since I've tried many medications and nothing has really helped.
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July 8, 2013 4:24 PM
Review by johnny734 (taken for 2 to 5 years):
Deplin (l-methylfolate) for Depression: I want to I really say people should wait at least 3 months before they rate Deplin or any psychiatric medicine, unless you have some major horrible reaction. Deplin gave me a kick start the first week I took it for some reason but then the effects disappeared. I talked to the P-doc and he said it takes something like 6 weeks to build up in your system. Well after about 6 weeks or so I started to notice the effects. It gave my Wellbutrin a huge boost and my energy level rose through the roof. People rating a medicine after 2 days is just ridiculous and annoying. Even the SSRI's take a couple weeks to work. Stop it people.
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April 20, 2013 2:20 AM
Review by Anonymous:
Deplin (l-methylfolate) for Depression: I'm so happy for you all. It is just pure hell dealing with depression, no sleep, continual thoughts, obsessive compulsive disorder, and not happy at all. Maybe if we all get figured out that this is what we need. Imagine how cheap our health insurance could go to. This is wonderful, I take folic acid and it does make a big difference.
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April 10, 2013 2:09 PM
Review by Mark2112 Deplin works for me. (taken for 6 months to 1 year):
Deplin (l-methylfolate) for Depression: Deplin worked for me but is not for everybody. I have the genetic mutation which others on this website have talked about, which keeps the body from processing folic acid into L-methylfolate which is needed by the brain for the other neurotransmitters to work properly. A blood test ($280) proved this. Before Deplin I was was on Bipolar meds (including Seroquel which was miserable) and antidepressants. Now I am only on Deplin and Clonazepam for chronic anxiety and am feeling re-energized.
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January 5, 2013 10:07 AM
Review by Anonymous (taken for 1 to 6 months):
Deplin (l-methylfolate) for Depression: I have had treatment-resistant depression for 20 years and have tried Zoloft, Prozac, Effexor, Paxil, Celexa, Wellbutrin, Lexapro and Viibryd. Lexapro (20 mg) and Wellbutrin (300mg XL) seem to work best but even with talk therapy, good diet and exercise I still have never achieved full remission. After my psych doctor retired, I switched to another who had me tested for MTHFR mutations and started me on 15mg of Deplin. Within 7 days I felt better than I could ever remember - it was like a light switch! Test results showed I am homozygous for the C677T MTHFR mutation. I stopped taking Deplin after some agitation & anxiety started; I restarted on a lower dose before ramping up to 15 again. I have yet to see the same improvement after 3 weeks.
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December 17, 2012 12:37 AM
Review by Anonymous (taken for 6 months to 1 year):
Deplin (l-methylfolate) for Folic Acid Deficiency: I was tested for MTHFR genetic mutations after several years of fibromyalgia/chronic fatigue type symptoms. BINGO! I have compound heterozygous mutations. Which can cause whole host of health issues, many I have been experiencing since youth. Once I started 7.5mg of Deplin with Methyl b12 my aches, brain fog, and unrelenting fatigue started to diminish..this is a life changer!
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September 12, 2012 8:54 PM
Review by Suzeeh:
Deplin (l-methylfolate) for Depression: I lost my only child four years ago and have battled grief and depression. I was put on Deplin and it made a huge difference in my frame of mind. I went off of it a month ago because I started a new job and basically just forgot to get it filled. Big mistake. I have been extremely sad and depressed. I will be getting that prescription filled tomorrow. It was a lifesaver.
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April 13, 2012 12:35 AM
Review by Elsie Aches:
For Depression: I have suffered from depression for about 30 years.. crippling depression with anxiety since 1992. I am 62. I have taken nearly every antidepressant and none really worked. I read this forum about four months ago and decided to order 5-MTHF,10 mg. After about three weeks, I realized I was coming up from the deep depression. I was taking 20 mg of Lexapro and cut that down to 10 mg a day. I am excited that this might be what I need but will wait a while before foregoing with the Lexapro because I'm not ready to enter that deep depression if this doesn't work by itself. I am so excited even if I do have to continue the Lexapro. To feel like getting out of bed, doing normal things and feeling good is great. I will post updates.
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February 24, 2012 4:18 PM
Review by WhoCares(::
Deplin (l-methylfolate) for Depression: I have had depression for 8 years and nothing has ever pleased me.. I just had a baby 5 weeks ago and my depression like doubled! I felt so lost and I really thought I was losing my mind!! I just wanted to end my life! I told my OBGYN and he gave me this medicine and I really haven't felt this good in years! It makes me feel relaxed and do nothing but laugh! My mom said she hasn't seen me this way in years! I was pushing my sons dad away because of how I been feeling but I just been so happy around him now! I can handle the baby's crying better and most of all myself! I just feel alive again. Thank you Deplin!
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February 22, 2012 2:09 AM
Review by Anonymous:
Deplin (l-methylfolate) for Depression: I was diagnosed with depression 11 years ago. I can't remember all of the anti-depressants I've been on, but for the last 5 years I've been on Welbutrin 450mg. My psychiatrist prescribed Mirtazapine, for it's energizing effects when on high doses. It didn't work for me; then he prescribed Deplin 15mg. I took it for 6 weeks. I could not tell a huge difference, so I didn't refill my prescription right away. (It's expensive since insurance won't cover it!) After I stopped my energy/motivation decreased, so I started taking it again. I've been on it for about a week now and have seen an increase in my energy again, but the motivation is still not as high as I it should be. Hopefully it will get better the longer I'm on it.
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February 20, 2012 2:00 PM