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Diphenhydramine User Reviews & Ratings (Page 5)

Brand names: Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Diphen, Unisom SleepGels, Sominex, Nytol, Benadryl Children's Allergy, Sleepwell 2-nite, Buckley's Bedtime, Diphenydramine Quick Melt, Simply Sleep, Bydramine, Aler-Dryl, Valu-Dryl, Hydramine, Nytol Caplet, Compoz Nighttime Sleep Aid, Allermax, Histaprin, Unisom SleepMelts, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, ConRx Allergy, Dicopanol, Hyrexin, Hydramine Cough Syrup, Diphenhist, Diphedryl, Diphen AF, Diphen Cough, DPH, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Diphenadryl, Genahist, Aller-G-Time, Sleep Tab II, Nytol QuickCaps, Trux-adryl, Diphenyl, Altaryl, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Silphen Cough, Diphenylin, Hydramine Compound, Sleepinal Help I Can't Sleep Diphendryl Twilite Banaril Aler-Tab Siladryl Allergy Sleep-ettes D Diphenmax Ben-Tann Dytan Vanamine PD Pharbedryl Z-Sleep Complete Allergy Relief Dytuss Dormin Miles Nervine Scot-Tussin Allergy …show all brand names

Diphenhydramine has an average rating of 5.4 out of 10 from a total of 518 reviews on Drugs.com. 44% of reviewers reported a positive experience, while 41% reported a negative experience.

Reviews for Diphenhydramine

  • Morgan...
  • November 15, 2015

For Nausea/Vomiting "I tried everything yesterday to stop throwing up acid. I went from Nexium to Zantac to pepto to tums, nothing helped and it all just came back up an hour later. Thankfully my brother is a paramedic and told me about how they use benedryl for their nausea patients so I took 3 of the 25mg tablets and it worked!!"

10 / 10
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22 Report
  • Nickccc
  • September 8, 2015

Sominex (diphenhydramine) for Insomnia "Funnily enough, after taking this. I feel more easier to fell asleep during the day than in the night. After a unintentional 12 hours sleep( just couldn't wake myself up). Was awake for a few hours then was too drowsy and fell asleep again. Really feel these tablets works better during the day than in the night. : ("

5 / 10
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22 Report
  • lab_l...
  • August 24, 2008

Compoz Nighttime Sleep Aid (diphenhydramine) for Insomnia "After trying several different sleeping aids, I ran across Compoz in K-Mart. I hadn't seen it anywhere else so I thought I would give it a try. I got a good nights sleep for the first time in quite a while. I still take it occasionally and still get that qood night of sleep. You can't take it every night for an extended period of time or it won't work as well, I can promise you that. "

8 / 10
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34 Report

Frequently asked questions

  • Ruthie
  • Taken for less than 1 month
  • November 4, 2019

ZzzQuil (diphenhydramine) for Insomnia "I only took ZzzQuil for two nights. Both nights I slept just a few hours and woke up with a bad headache two mornings in a row that Advil didn't help and it usually always does. I also noticed yesterday when watching a football game that my vision was acting weird, blurring like. I DO NOT recommend this to anyone. I have tried many over the counter meds and nothing really works - does nothing at all for me but this stuff made me miserable."

1 / 10
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13 Report
  • Scout
  • August 23, 2020

Nytol (diphenhydramine) for Insomnia "A complete waste of money. I have had recent sleep problems so thought this would be a solution. It had no effect whatsoever apart from causing a headache. This made the dire warnings I got from the pharmacist when I bought it about long term usage and dependency completely laughable. I considering returning the garbage to them and demanding my money back."

1 / 10
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11 Report

Are you taking this medicine?

  • Thelma...
  • Taken for 1 to 2 years
  • August 13, 2022

Sominex (diphenhydramine) for Insomnia "I'm in constant pain as waiting to be called in for hip replacement so just cannot sleep. Also even though I'm tired, my brain just will not turn off. SOMINEX is a brilliant over the counter pill that it lets me sleep ALL night. I take half to one pill when I go to bed as I like to read before sleeping. I start feeling relaxed and ready to sleep after about an hour and then before I realise its morning. I wake up fine with no problems at all. I shall continue taking these - I'm 70 years of age - till I meet my maker."

10 / 10
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6 Report
  • Robert
  • February 1, 2024

Benadryl (diphenhydramine) for Allergic Reactions "I had a headache attack in June of 2023 and a seizure and had to be put in the hospital. They gave me Ativan, Benadryl, and IV Tylenol as a headache cocktail and it worked like a dream! After 5 days in the hospital, I was all better after that nasty headache."

9 / 10
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1 Report

More FAQ

  • Miche...
  • Taken for 2 to 5 years
  • April 11, 2018

For Nausea/Vomiting "Better known as Benadryl; Every time anyone is puking I can always rely on this to immediately stop it. (Chewable form) My children have struggled with nausea with no help from any medication until this was brought to my attention. This is the absolute only thing I will use for nausea/vomiting."

10 / 10
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15 Report
  • Brandi
  • Taken for less than 1 month
  • September 1, 2020

ZzzQuil (diphenhydramine) for Insomnia "For years, I’ve suffered from insomnia. I could fall asleep, but I would often wake hours earlier than I was supposed to and would wind up exhausted all day. Lately, I’ve had trouble falling asleep in addition to staying asleep. I’ve tried melatonin and sleepy tea with no success, but I was desperate and gave zzzquil a try. I typically get very sleepy 30-60 minutes after taking it and can sleep for 8 hours without feeling “hungover” in the morning. My body is actually a little stiff when I get up because I haven’t even moved all night."

10 / 10
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10 Report
  • Julia
  • July 21, 2017

Benadryl (diphenhydramine) for Allergic Rhinitis "I have a lot of allergies. About a year ago I began taking benadryl at night to help me sleep. It also helped a lot with the allergies. I only take it at night because of the drowsiness. Recently my stomach was upset for a month and I noticed they've begun putting calcium in it! This is so upsetting! Calcium stimulates stomach acid and people with allergies are sensitive to acid. This has been documented in the allergy journal. I would have thought a pharma company would know better than this! I wish the two corp. drugstores in my area had a better selection of drowsy antihistamines. They mostly have only benadryl. CVS has chlorphen, but it has lactose in it. :( For now I'm making do with a Walgreens combo that includes chlorphen."

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16 Report
  • peter
  • Taken for less than 1 month
  • October 15, 2019

ZzzQuil (diphenhydramine) for Insomnia "I was using the liquid form and it was fine, working for me, but yesterday I took 2 of these pills, I slept for 5 hours, and now I have terrible headache. I took 2 pain killers, but doesn't help at all. I can't sit or work or concentrate. Terrible pill, will not take it again."

1 / 10
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12 Report
  • Opal
  • Taken for 6 months to 1 year
  • February 27, 2023

Banophen (diphenhydramine) "It is a lot less cheaper than Benadryl. The average 25-pack of Benadryl that I have seen is about $12, while the average 100 pack of Banophen is about $4 that I have seen. Benadryl seems to give more negative side effects than Banophen, which is a bit odd, considering they have the same exact active ingredient. Overall, I trust Banophen more and use it much more often."

9 / 10
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4 Report
  • Melan...
  • Taken for 5 to 10 years
  • July 24, 2019

For Nausea/Vomiting "Uhhhhhh.... wow..... all I have to say, is that I have had extreme nausea all night... I tried Dramamine. Didn’t work. I remembered that diphenhydramine can also be used for nausea relief. So I took a liquid gel (50 mg) And it’s been maybe 10-15 minutes and I already feel better. THANKS AGAIN DIPHENHYDRAMINE !!"

10 / 10
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12 Report
  • lew85x
  • Taken for less than 1 month
  • January 14, 2019

Nytol (diphenhydramine) for Insomnia "Been experiencing insomnia 2 weeks after stopping smoking weed, tried meditation, mitrazapine, chamomile tea, yoga now nytol. I took one 50mg as stated and still wide awake 2 hours later - no good! Anyone know of anything else to try. My dr is useless and won't give me sleep tabs although I had previously had diazapam and zopiclone and they were the best."

1 / 10
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13 Report
  • Loano
  • December 24, 2018

Sominex (diphenhydramine) for Insomnia "I think this is a brilliant drug to take when you want to break a run of bad nights. I tried it as I couldn't take Night nurse (which I used to take) as it has contra indications with another tablet that I take at the moment. I only need half a tablet, like other people, I can get up in the night if I have to and go back to sleep. I wake up feeling refreshed. Thank you Sominex."

9 / 10
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13 Report
  • Non...
  • Taken for less than 1 month
  • December 26, 2020

Nytol (diphenhydramine) for Insomnia "I've used nytol one a night before and it's been extremely effective short time. However I've used it recently and had the most disturbing effects. Awful repetitive dreams... Waking me scared after 2 hours. Getting up then my vision was let's say very distorted with all I can was that if I looked in an empty coffee cup it looked like thousands of tiny flies were buzzing around in it. I used it the next night with exactly the same effect so I will never use it again.. Would rather go without sleep!!!"

1 / 10
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9 Report
  • DeeJayS
  • March 4, 2014

For Insomnia "I have been taking half of a pill for years...but just recently have felt that it has not been as effective, so increased to a whole pill (25mg) and it works great with no sluggishness the next morning. Also ever since I have been taking these every night for sleep, I have noticed that I have fewer sinus infections..(I have allergies)...so it serves two purposes for me.."

10 / 10
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20 Report
  • Anonymous
  • Taken for less than 1 month
  • October 2, 2020

Nytol (diphenhydramine) for Insomnia "I went on a trip away and the change of environment i.e. sleeping in a different room and change of bed made it very difficult for me to sleep - I had 3 hours sleep for 2 nights running so decided I needed to do something about it. I tried Nytol and it made me sleep an average of 8 hours so worked really well. The only downside is the 'fuzzy' head feeling the next day and feeling spaced out. However, for a short-term solution when you need to get back into a good sleep rhythm, I would highly recommend it. Not for taking long-term though."

8 / 10
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9 Report
  • emano
  • Taken for less than 1 month
  • September 23, 2020

ZzzQuil (diphenhydramine) for Insomnia "I hate zzzquill. I took multiple doses one night when I had to wake up really early in the morning and if anything it woke me up. I ended up getting such little sleep and I regret ever even giving this company my money"

1 / 10
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9 Report
  • Knack
  • April 9, 2021

Nytol (diphenhydramine) for Insomnia "I have just about tried every potion, lotion & tablet to find a cure for my insomnia. Nytol was probably my last hope. I paid £11.99 for a bottle at my local pharmacy, I can honestly say it's £11.99 wasted. Utterly useless I would have been better off with a glass of hot milk. I'm typing this at 4.am after yet another sleepless night. I've now given up and just accepted the fact that I will never get a decent nights sleep."

1 / 10
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8 Report
  • marlene
  • Taken for 10 years or more
  • June 14, 2018

Benadryl (diphenhydramine) for Allergic Reactions "I've used this and given it to my children for over 20 years. My teenage son would take 1 before going to bed so he could sleep without allergic reactions. I've used it for unknown allergies like bee stings and sunless tanner. Works great and so does the topical cream. No adverse affects with us."

10 / 10
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13 Report
  • Migra...
  • Taken for 5 to 10 years
  • May 19, 2018

For Nausea/Vomiting "Diphenhydramine has saved my life. I have a severe migraine disorder that comes with extreme nausea and sudden vomiting. I now take LIQUID Diphenhydramine, sold as Children's med, for nausea and vomiting. I tried pills and they are not fast acting enough and the dose is too high, so it makes me very sleepy. The smaller liquid dose knocks my nausea out almost immediately and only makes me mildly sleepy. I carry this med on hand at all times and take it as needed when I feel the first sign of nausea. If I feel like a full migraine is coming on, I'll take the complete adult dose. The reduction in nausea, in addition to the powerful sleepiness, can really help me avoid more expensive or risky migraine abortive medications. I've taken this medication for years and the only chronic side effect that I've noticed is dryness/dehydration, but I compensate for that with added water and fish oil. Thank you scientists for diphenhydramine!!"

10 / 10
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13 Report
  • user
  • Taken for less than 1 month
  • January 7, 2020

Unisom SleepGels (diphenhydramine) for Insomnia "I’ve taken two 50mg pills and I am wide awake, other sleeping medications have done a way better job but they eventually stopped working which is why I switched brands to see if it’d help, I feel like I wasted money"

1 / 10
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10 Report
  • Firefly
  • Taken for less than 1 month
  • January 17, 2021

Nytol (diphenhydramine) for Insomnia "I decided to try these after a period of either not being able to sleep or waking up and not getting back to sleep. Having read quite scary side effects of prescription sleeping tablets I thought I'd try these first. So... I did drift off to sleep around 30-40 mins after taking a tablet. I woke up in the night to go to the bathroom but did get back to sleep much faster than usual. The downside was feeling spaced out (bit like a hangover) until lunchtime the next day! I'd not take them if I had an early start or important meeting. I'd recommend trying them but don't expect anything amazing. If your sleep issues are acute due to a trauma etc then I'd suggest these wouldn't work sufficiently."

6 / 10
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8 Report
  • Joe
  • Taken for less than 1 month
  • March 5, 2018

Nytol (diphenhydramine) for Insomnia "I took one to help with sleep during a stressful project and so did my partner. I had the most horrendous nightmares of people committing suicide. Never again I thought. I mentioned to my partner and he had exactly the same experience. I very rarely if ever have bad dreams. This drug is natural Valerian root which I researched online afterwards and there is a lot of similar experiences reported. But the side effect is not mentioned in the notes with the drug. Its not a great experience. I'd recommend avoiding it completely."

1 / 10
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13 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.