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Premarin User Reviews & Ratings (Page 2)

Premarin has an average rating of 7.5 out of 10 from a total of 77 reviews on Drugs.com. 68% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Premarin

  • jas-09
  • December 31, 2008

For Oophorectomy "I have been taking Premarin for (the better part of) 25 years. Due to insurance changes through this time I've been directed to use other estrogens. I will emphatically state that there is NO substitute for premarin. The others gave me breakthrough hot flashes and PMS. With all of the plumming gone, these were not acceptable being 32 years old. Premarin every day has kept me at an steady keel with no wavering in mood or temprament."

10 / 10
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87 Report
  • CherryP
  • Taken for 10 years or more
  • December 23, 2015

For Oophorectomy "After a full hysterectomy in 2000 with both ovaries removed, I was given Premarin straight after surgery. My Dr now refuses to continue the treatment, and her colleagues will not prescribe as I am her patient. Now 3 months without and horrendous problems with lack of energy, emotional outbursts, hot flushes and vaginal skin tearing. Dr. still refuses because of cancer risk. I thought that would be MY choice: for better quality of life. What to do? Flew to Malaysia and bought OTC. Life getting back to normal now. Only side effect may be the slight bloating, but I'm careful what I eat and drink to reduce this."

9 / 10
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52 Report
  • Gator
  • Taken for 10 years or more
  • October 9, 2016

For Osteoporosis "I started taking Premarin 1.25mg when I lost my ovaries at the age of 28 to endometriosis. That was 33 years ago. My symptoms were lack of focus and energy. Within a week or two I was back to my normal self with the exception of the mood swings I'd had ever since puberty. Several years ago my GYN said there was an alert about Premarin and I would have to wean myself off of them. I went down to 1/4 of what I was taking within 7 months. I was taking large doses of ibuphrofen for over 25 years for inflammation in my back. When the Premarin was decreased and the ibuphrofen was taken down I developed extreme arthritic swelling in some of my joints. I was put back in the Premarin immediately and told to never get off."

10 / 10
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47 Report

Frequently asked questions

  • Concern
  • Taken for 10 years or more
  • December 15, 2019

For Postmenopausal Symptoms "Immediately after total hysterectomy in 2006, I was prescribed Premarin 1.25. Worked great for all my menopause symptoms. My doctor recently told me to stop taking the medication due to the side affects in which one that caught my attention was blood clots. Well, to make a long story short, back in 2016, a MRI discovered a blood clot in my head, in which it was caught before it ruptured."

1 / 10
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27 Report
  • SHE1LA
  • Taken for 5 to 10 years
  • June 11, 2016

"I had to have a total hysterectomy in 2009 including removing both ovaries at the age of 38 because of endometriosis. I have been on premarin 0.45mg since. I only have to take one every 3 days to keep the hot flashes at bay. I tried going off of it twice because even with insurance it was $50 but I thought I was going to die!!!! I could not sleep at all, the hot flashes were horrible, I had no energy to do anything but lay all day on the couch. My life might as well have been over if I didn't have this drug. I have no side effects on it and I thank God I have it."

10 / 10
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41 Report

Are you taking this medicine?

  • Linda
  • Taken for 10 years or more
  • May 8, 2018

For Oophorectomy "I took Premarin 0.625 following an oophorectomy at 36. At 58 I was advised to come off it, as I was past the age of menopause but I got really bad Atrophic Vaginitis. I went back on it for another 7 years and have been off for a year. Doctor now reluctant to write prescription as I'm 65. Now been given Vagifem but miss my Premarin so much. Anyone take it after 65? Tempted to buy on Internet but worried that might stop too. No health issues or other medication"

10 / 10
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32 Report
  • Jah
  • April 5, 2021

For Postmenopausal Symptoms "Best for me. Tried all of HRTs, estrace pills, patches, pellets, injections and premarin works best tho not cheap. Premarin pills 1.25mg 2/day plus Premarin cream 1 gram daily plus low dose progesterone (2.5mg) the only solution for me. Had endometrial ablation years ago and don't need progest but found tiny dose helps the prem work better. If you have trouble means either the dose, brand or delivery is not correct for your chemistry. The progesterone most MDs rx is Prometrium 100mg, only during pregnancy does a woman's body ever make that high a level! Pre-meno non preg women only produce ~25-30mg progesterone daily and ~1.5-9.0 mg estrogen daily. Progesterone can convert into estrogen which can help meno symptoms but it doesn't convert in all women the same. Prometrium was much too high for me (gave me bad symptoms) I needed less progesterone and higher estrogen to feel balanced. Watch youtube videos of Menopause Taylor (Dr. Barbara Taylor) she explains everything."

10 / 10
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19 Report
  • Anonymous
  • August 31, 2011

For Primary Ovarian Failure "I couldn't take Premarin for about 5 years when I needed to because of cancer. I had bad symptoms. You name it - as far as having a hard time while being in my "change" period, I had them all. When the doctor finally put me on Premarin and it took effect I could have jumped for joy. I was myself again. I loved being on it. All the symptoms went away. I was so thankful. I was on it for many years. I tried to cut back at times but all the bad feelings would come back. Last year my doctor took me off it. He told me to take Estrace. It would be better for me. I'm having a hard time. Estrace does not work and my symptoms are back with a furry. I'm trying to find a doctor that will give me Premarin. "

10 / 10
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56 Report
  • For...
  • August 19, 2017

For Osteoporosis "My Dr. retired & his replacement stopped 5 of my drugs (all now prescribed by specialists). However, Premarin was stopped for 1one anda half months. Two weeks later, 40 hot flashes a day began. I felt like I was going to die. Finally, an endocrinologist re-prescribed Premarin but only 1/2 the dose I had taken for 32 years (since 40). Hot flashes are still outrageous. All my sisters have osteoporosis, but not me (I took HRT). In the time it was stopped, I lost weight, lost 1" in height, about 20% of my hair, and I'm so tempted to order it online without a prescription so I can take the other half of my regular dose. Desperate people do desperate things."

10 / 10
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34 Report
  • Brave...
  • October 30, 2019

For Hypoestrogenism "I suffered from endometriosis after my 1st born baby girl 1980(natural birth). Treatment from South Africa's Fertility Specialist (1983-1989) helped me through x 3 miscarriages and hopelessness. Eventually I fell pregnant; cesarean baby girl 1988 and my Son born 1989. Still suffered endometriosis. My son was 3 days old when I had hysterectomy done; left Ovaries in tact and put me on Premarin; weakest dose. Over years changed to 1.25mg which I've used the past 11yrs. Never had side effects EXCEPT a fair shade SKIN BLEMISH on my chin. I've remained slim/trim yet I've live a healthy active lifestyle. NOW however -- I'm now 61 and no clue whether to stop using Premarin. I did for 2/3mths but had hot flushes & strong mood swings. Google info warns of Danger to health if taken longer than 10yrs. I've taken it NOW FOE NEARLY 30yrs! ANY ADVICE / must I stop ?? Love to hear of anyones else experiences in a similar situation Bravegirl"

10 / 10
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25 Report
  • BossL...
  • March 31, 2020

For Postmenopausal Symptoms "My third month using Premarin 0.625g due to unbearable hot flashes, vaginal dryness, sleep disturbances and night sweats. I had done hysterectomy about a year ago. Since taking Premarin, both hot flashes and night sweats lessened. Now my biggest challenge is persistent and enlarging painful breasts. Am due to discuss this feedback with my gynecologist."

8 / 10
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23 Report
  • cdluce
  • February 13, 2012

For Atrophic Vaginitis "I've been on it almost 3 years. I had to start using this in my mid twenties. I can use very little to the normal amount every 3 days or so. I go by how I feel more then anything. I do notice belly swelling the next day and I do get headaches if I use to much. Other then that I love this and I'll keep using it. Make sure you get your yearly check ups/blood work and you'll be fine."

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52 Report
  • Kstd
  • April 25, 2016

For Postmenopausal Symptoms "I was prescribed premarin 1.25 right after a total hysterectomy 11-1983. This was to help avoid at age 32 hot flashes, dryness in skin and hair, and protect my bones. Personal dryness. I took it for 20 yrs. Then when the doctors thought I was having a heart attack in in 4-2004 they took my off of it cold turkey. in 2-2009 I was found to have stage 1.5 breast cancer. Cancer dr. told me it was from taking premarin for 20 yrs. Should only been prescribed no more than 7 yrs. The cancer was caused by extra hormones. Extra hormones was driving my endometriosis that was the cause of removing everything in 1983. My cancer dr. said with my family background I was lucky never to had a major heartattack."

2 / 10
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  • Megan
  • February 14, 2020

For Oophorectomy "I took Premarin from the day after my hysterectomy at age 45 until a year ago at age 76. It was trouble free for me. My doctor finally insisted on changing me from the low dose pill to the cream. Anyway, my bone density tests show my bones to be 30 years younger than I am, my hair is thick, my skin is 20 years younger than I am, I have never had hot flashes or anything one would think I'd have had. I wish I was still taking it. But I didn't know about the horses/mares."

10 / 10
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21 Report
  • Maggie...
  • May 18, 2013

For Oophorectomy "I could not make it through one day without Premarin since I had my uterus removed. I take along with 24 mg. Bio-identical testosterone from Woman's International Pharmacy. Had the surgery in 1973 and suffered for so long, they even told me I had Lyme. I was bitten by a tick and crazy as it seems, these two hormones cured me. Go figure. I only use "name brand' Premarin like my mother and aunts used in the 50's when they used to combine Premarin and testosterone in one pill. I used to use that in the 70's 80's before bio-identical hormone cream. "

10 / 10
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39 Report
  • missi...
  • December 12, 2015

For Postmenopausal Symptoms "I have been taking Premarin a little over a month and my hair is starting to fall out, I am having stomach issues now, including odd bloating, and I still have hot flashes every day. I used to take Enjuvia and it was the best thing ever, but it is no longer being manufactured or distributed. I can't seem to tolerate anything else. Does anyone know of something better? I take the highest dose of this without causing the High risk for Breast cancer...I wish this stuff would work for me :("

4 / 10
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29 Report
  • Midwe...
  • Taken for 10 years or more
  • July 18, 2016

For Primary Ovarian Failure "I've been on premarin for over 20years. When I started I had side effects of bloating and constipation. Over time those resolved. I don't know why I'm still having hot flashes 20+ yrs after menopause. Now I take.625 every other day due to the expense. That works. If I try to cut back to every third day the hot flashes return in a short time."

7 / 10
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25 Report
  • Eve
  • Taken for 10 years or more
  • April 25, 2021

"I had a hysterectomy at age 32 and I am now 82 and have taken Premarin all the time since. I have tried to get off several times and had horrible side effects. Had one dr that refused to give me a prescription because she did not believe in it so had to go to another dr for prescription and get it in Canada now and much cheaper. Thanks for Premarin."

10 / 10
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12 Report
  • Carlit...
  • November 19, 2014

For Atrophic Vaginitis "I was prescribed with Premarin vaginal cream to use for 2 weeks prior pap. I had total hysterectomy 9 months ago. I experienced severe acid stomach from this medicine. I have a history of stomach acid so I didn't put the 2 together. I took my usual med, avoided food that could trigger acid but to no avail. I suffered for 5 days of severe acid stomach until I decided to stop the cream that night. The following day, my stomach still sore but not acidic. I woke up with a headache. I didn't think the cream will affect me this way since its effects are limited in vaginal area. I was wrong. I can confirm that my acid stomach was due to Premarin vaginal cream."

6 / 10
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27 Report
  • KCano
  • Taken for 1 to 2 years
  • March 17, 2019

For Postmenopausal Symptoms "I highly recommend adding a bio-identical to a premarin regimen. I began experiencing overactive bladder and recurrent UTIs. My PCP did not recommend an OBGYN until I was having the UTIs and wanted a compounded prescription. My dosage was played-with or changed many times without doing any bloodwork by my PCP. Don't think your PCP knows what they're doing. Get in touch with a doctor who works with a compounding pharmacy that specializes in hormone replacement."

5 / 10
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  • Sunci...
  • June 5, 2017

For Primary Ovarian Failure "I'm 75 and have been taking 1.25 since l had a full hysterectomy at 36. 10 years ago cut dose to .65 at Dr recommendation. Noticed no change. Now taking .325 for about 4 weeks. Do notice I'm not tired, not as "happy"... All those years no side effects. Bone density excellent. General health excellent.. Think I'll go back to .65 but its expensive and insurance will not cover due to my age."

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20 Report
  • DanDe
  • Taken for 1 to 6 months
  • February 22, 2022

For Postmenopausal Symptoms "I suffered from horrible night sweats, flashes all day long and a mean foul temper due to lack of restful sleep and lack of estrogen apparently. Had a partial hysterectomy at 44, started HRT at 50. Finally found a doctor who didn't just give me a pat on the arm and an antidepressant. Started with premarin and found myself. Sleep was restful, I could tolerate people and even enjoy them, my husband no longer was at risk of being the target of tears, anger, resentment, sadness, and happiness all in the matter of minutes...then my insurance said it was no longer covered. Tried a few other "covered" options and have been MISERABLE! The Flashes and night sweats are even worse. Wishing there was a synthetic form of this, hoping for a generic that works BUT have not been successful seriously trying to figure out how to make $500 a month to be able to stay on it and have quality of life."

10 / 10
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8 Report
  • sonokee
  • July 16, 2009

For Oophorectomy "In 1971 I had surgery and was put on 1.25 Premarin and told I must take it for life. Now in the year of 2009 looking back on all, I have to say I wish I had refused the surgery and didn't take Premarin. They didn't tell us about the possible side effects in those days, told only we wouldn't understand. I reported side effects to doctors, who did nothing. My huge stomach is finally beginning to shrink after being off Premarin for years. "

1 / 10
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34 Report
  • Dimples
  • Taken for less than 1 month
  • March 13, 2018

For Atrophic Vaginitis "I used this cream for one month. I had to stop because it made my breast hurt so bad. I have a history of lumps in my breast so of course when I found out this cream increase your chance for breast cancer I had to stop. Will not use again."

1 / 10
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17 Report
  • Terlo...
  • Taken for 10 years or more
  • May 4, 2020

For Oophorectomy "I had a complete hysterectomy when I was 46 yrs. old. Went on Premarin tablets immediately. On the advise of physician I have tried several times to wean off. Unfortunately, side effects were terrible so always went back on until now. I’m now 74 years old. I started weaning off a few weeks ago and am now totally off . Other than a lot hot flashes for the first week (not bad) and now just a few here and there, I’m doing great. I don’t think it helped my bones as I have osteoporosis and am taking Risedronate for that."

10 / 10
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12 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.