The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Anafranil (clomipramine) for Obsessive Compulsive Disorder: I have suffered from obsessive thoughts for 26 years. I have tried different medications over the years. I was on Paxil for 10 years but I never ever felt totally well and I slowly stopped taking it and became very ill. I started taking clomipramine again seven years ago. Again it saved my life and I have been able to have a successful career. I take 250 mg a day. I hate the side effect of weight gain but I will never sacrifice my mental health to lose weight.
15 users found this comment helpful.
Review by MelissaDutfield (taken for 1 to 6 months):
Anafranil (clomipramine) for Obsessive Compulsive Disorder: I started taking this medication 2 months ago, starting on 25mg but was too high as the side effects were bad for me so I started on 10mg slowly to 20mg and I think it has made a big difference. I am doing CBT too but the anxiety has decreased significantly. I suffer from intrusive thoughts and this helps it become more manageable and I feel that I'm living again!
12 users found this comment helpful.
Anafranil (clomipramine) for Obsessive Compulsive Disorder: Anafranil has always worked superbly for my obsessive compulsive disorder and I have used this medicine intermittently for 30 years. My mistake has always been to completely stop when I feel well - it always comes back.
Although an amazing medicine, the downside is that it takes about 8 weeks for the medicine to work and before that I usually feel worse. And the side effects can be a challenge.
17 users found this comment helpful.
Review by 123maybeitwillworkforme (taken for 1 to 6 months):
clomipramine for Obsessive Compulsive Disorder: I started taking this medication after suffering severe anxiety and unwanted thoughts for 13 years. I have been on this medication for approximately three months and the anxiety attacks stopped except for maybe two so far when it was 8 to 9 a day. The intrusive thoughts have not stopped yet but somehow the anxiety has, don't know how that is since the thoughts are what causes my anxiety but somehow it is easier to control my thoughts or get off of the intrusive thought that would have caused the panic attack. I am hoping 100mg helps me with the thoughts. Never stop trying and never stop being your own advocate in your mental illness. 13 yrs for me.
12 users found this comment helpful.
Anafranil (clomipramine) for Obsessive Compulsive Disorder: It has worked really well for my severe OCD, depression, anxiety and panic. It stabalizes my mood too. The side effects are awful for me, though. Sexual side effects (like my genitals are numb) and severe constipation are the two side effects that keep me from being on a more therapeutic dose. At 100mg, the side effects are bad. At 50mg I'm OK in terms of side effects, but the benefits are minimal. I will be going up to 75mg and see how that goes.
In the past I had been on 150mg and then 200mg. I had never been happier. I think I may have been too happy rather than normal happy, though.
21 users found this comment helpful.
Anafranil (clomipramine) for Depression: After 6 years with very strong depression that nothing helps, this medicine saved my life. It takes more then a month to kick in and it continues to grow for full year but after you use it you fill strong and don't think about depression anymore. If you have resistant depression you must try this. It's a totally different class than the rest. I also tried all the natural 5HTP, St. John's Wort and the rest and nothing helped.
17 users found this comment helpful.
clomipramine for Depression: This medicine saved my life. I have now been on it for 12 years for anxiety and depression. I tried a whole slew of SSRI's over a three year period with minimal success prior to clomipramine. A week after starting clomipramine I started to feel better but had some major side effects (dry mouth, constipation and later weight gain). With the SSRI's I had no or minimal side effects. I thought maybe these side effects mean the medicine is working. The side effects continued for about 5-6 weeks but damn I started to feel like my old self. I gained about 15 pounds in the first 8 months but I didn't really care because I could live again and enjoy my family and friends. The weight all came off after about a year with exercise and eating right. Awesome!
18 users found this comment helpful.
clomipramine for Obsessive Compulsive Disorder: I was first prescribed this medicine for severe/major depression at around eighteen-years-old. I had tried various forms of psychotherapy and nothing had worked; over the course of a year the depression had worsened to the point where I could no longer function. 50mg of Clomipramine transformed my life after about ten days. It has been, for me a life-saving medicine. The side-effects are sometimes bothersome, but to this day it regulates my mood almost perfectly and I can live a full life. Highly recommended.
16 users found this comment helpful.
Review by curlywurly (taken for 10 years or more):
clomipramine for Panic Disorder: My panic disorder with agoraphobia started when I was 16. Clomipramine (Anafranil) is the only thing that controls it. I am now nearly 60 and still take a small dose 25mgs per night. I have tried repeatedly to manage without Clomipramine and to begin with it is fine but then eventually the panic attacks recur and are very debilitating. Thanks to this I have been able to lead a fulfilled life - working both at home and abroad, travelling, driving and looking after children and husband. It frees me up to be myself. I have tried cognitive therapy and other things but always come back to this. It is not nice to be on a high dose though as it affects sexual response. This is why it does not get 10 out of 10.
Anafranil (clomipramine): Started out good, then headaches then sleep problems. After that muscle spasms, also weakness, although I started feeling better to start with as far as my mood and depression.
clomipramine for Depression: Side effects were really unpleasant but 2 months in have lessened to some degree - as an effective anti-depressant it is the best I have ever taken. I have been on just about every anti-depressant out over the last 20 years with nothing really working and worsening depression. I started to feel a lifting in mood almost immediately and now feel "normal" which is an awesome feeling. My social phobia/anxiety has almost disappeared too which is an added bonus. Wish I had been prescribed this years ago!
20 users found this comment helpful.
Anafranil (clomipramine) for Obsessive Compulsive Disorder: I have used Anafranil on and off for 30 years. Each time it has worked superbly. I stop and then start again about 2 years later, for a period of about 4-6 months. Presently taking 200 mg along with Beta Blockers - the best experience ever: I am happier, more confident and less anxious than ever in my life. Anafranil side effects are sometimes bad: loss of appetite, sexual dysfunction and blurred vision tend to him me badly. Also can take 2-3 months before they really work. But worth the wait, even though it feels for a while as though it makes you feel worse. Outstanding medicine - a life saver!!
56 users found this comment helpful.
Review by PGclomipramine (taken for 1 to 6 months):
clomipramine for Obsessive Compulsive Disorder: Miracle! I had obsessive thoughts that I recognized and could not get rid off. Tried years of therapy and one year of Lexapro with no results. The thoughts had cost me relationships in the past and was starting to ruin my latest and best one also. I finally tried Clomipramine. Even at the low dosage of 25mg, I started to see results after two weeks of taking it. The side effects are a drag but they start going away. Worst one for me is the anorgasmia though which is getting better slowly.
clomipramine for Obsessive Compulsive Disorder: I had suffered debilitating OCD from the age of six and Chlomipramine has improved my condition 95%. It also handles my chronic sciatica beautifully. Diminishes pain by about 70%! Constipation and sweating are my only side
effects. And that's not much of a problem. I'm 45 and finally enjoy life.
clomipramine for Panic Disorder: I've been on clomipramine 15 years now and basically saved my life. I suffer terrible panic attacks but they stopped straight away/. I come off my 25 mg tablets for 9 months, felt good but slowly my panic attacks came now back on 25 mg and feel good again.
Anafranil (clomipramine) for Obsessive Compulsive Disorder: Anafranil : Most likely the best medicine for obsessive compulsive disorder, overall. Yet each person has their own body chemistry/energy issues.
Most people with OCD need about 100 to 200 mg at night. The key is to GRADUALLY go up in dose. This will give your body TIME to ADJUST to Anafranil. I am now up to 150mg, after 3 months and I am feeling much better. Much less OCD thoughts. Yes, sexual side effects...as with any OCD medicine. I used to take high dose Paxil for 8 years and it just wore out, OCD came back.
I think I will try Anafranil 200 or 225 mgs, stay on it for a year, then see how I do as I try to wean down the dose to 50 or so.
43 users found this comment helpful.
Anafranil (clomipramine) for Panic Disorder: Have been on Anafranil for 5 weeks now. Prior to starting this medication I tried Lexapro (horrible panic attacks no sleep), Zoloft (made me depressed, worsened anxiety), Cymbalta (dreamlike state, made me totally dysfunctional), dothiepin (slightly alleviated anxiety but not much). I have only taken Anafranil for 5 weeks and it has already cured me of chronic anxiety, panic attacks. Took 4 weeks to really start working but turned out to be a surprisingly effective medicine. I feel great for the first time in years and am starting to get my life back. It has also helped my agoraphobia a great deal, magical stuff.
30 users found this comment helpful.
Anafranil (clomipramine) for Obsessive Compulsive Disorder: This drug was a MIRACLE for me! My problem was that I was always LATE for any and every little thing I attempted to do and it was ruining my life. It is VERY baffling for me because I started with only 25 mg and within FOUR days I was AUTOMATICALLY, not just on time, but EARLY for everything, without any thought or effort! I was ecstatic. This phase lasted 3 weeks. The doc said I'd be a Super Woman when she amped me up to 50 mg. Well, that made it STOP working! I began to slowly regress, and then started to be extremely drowsy to the point of even falling asleep at the wheel -- and worse, it wasn't even working! We experimented with it but it NEVER worked again and I am super sad about that.
27 users found this comment helpful.
Anafranil (clomipramine) for Obsessive Compulsive Disorder: This has been a miracle for me. I suffer from extreme OCD that had left me at times in a state of paralysis and constant fear. This medicine gave me back my life. It will not get rid of all of the OCD for you, but it will make it 90 percent manageable. The Dr who gave it to me was old school. None of the SSRIs worked for me. They were like sugar tablets. This one does. Highly recommend you speak to your physician about it as an option.
55 users found this comment helpful.
clomipramine for Obsessive Compulsive Disorder: Clomipramine changed my entire life. I use it for TOC. Before trying it, I used almost any medicine you can name, and none of them helped me at all. I just love it. Not only that but, at least for me, It's almost side-effects free (unlike almost everything else I tried before). My only problem is with my orgasms. My libido is very healthy, and I feel pleasure just like anybody else, but sometimes, It just take me a lot to reach an orgasm (not always, but most of the time).
Anafranil (clomipramine) for Obsessive Compulsive Disorder: I have/had severe OCD. I have been on citalopram, Zoloft and Prozac. I was started on 150mg Anafranil and within what seemed no time at all my OCD disappeared. Prozac did work for OCD but not on clinical depression. I am now on 200mg. I have had no weight gain (nor did I have on SSRIs). I get a dry mouth sometimes but counteract this with a anti dry mouth toothpaste.
24 users found this comment helpful.
clomipramine for Obsessive Compulsive Disorder: This medicine worked wonders; I was not as paranoid as before, and was able to eat something that had fallen on the counter and things like that (before, I wouldn't have dared). It also made my depression evaporate. Unfortunately, it also caused intense hunger, in turn causing weight gain, and gave me headaches, made me hydrated, and caused frequent urination on the flip side. I'd still recommend this medicine. I'm sad it didn't work out for me because it was really great.
Anafranil (clomipramine) for Obsessive Compulsive Disorder: After three years on different anti psychotics, I started taking this finally to some releif. I have been taking it now for about six months. It is still working well for obsessing, but the side effects are starting to add up. I have steadily gained weight. Severe dry mouth at first, not so bad now though. Total anorgasmia fixed by Viagra, and uncontrolled twitching. It sounds bad when I write it down but compared to the antipsychotics it's much better. I still feel better than I have and so much happier.
32 users found this comment helpful.
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