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I've been on Saphris 20mg nightly for 2 months. I have Bipolar Rapid Cyclical with ADHD. This medication is the best. I fall asleep within 10-15 minutes. The horrible taste is a small price to pay. My mood is the most stable it's been in a long time. I'm happy about life, feeling very positive- a huge change for me!
I was diagnosed with Bipolar Disorder almost five years ago and have tried just about every medication without success. I have recently started taking Saphris and it is my miracle. My mood swings have gone and I'm no longer angry or depressed. I have plenty of energy (minus the mania) and feel a complete sense of well being. The dissolvable wafers have a very bitter taste however this is a very small price to pay considering how awesome I feel.
Saphris has slowed my thoughts down a lot! I have the black cherry flavor. I do feel suicidal, but I felt that way before the meds. The only problem I have is the weight gain. I've been on Saphris for almost 2 months and have gained 20lbs. I find it hard to shed the weight.
I just replaced my 75mg nightly Seroquel with 5mg (will probably go to 10) of Saphris. I was very scared to change. I am a successful and happy trauma nurse, mom, partner, etc., even though I do struggle with bipolar disorder and anxiety. My life has been going REALLY well for several years with low doses of Seroquel, Zoloft, and Lamictal, so when my annual spring crazies kind of snuck up on me worse than normal, I was very hesitant to rock the boat. So far this compares VERY FAVORABLY with my Seroquel. I am sleeping well and the morning fog is getting better as my body adjusts. My thinking is clearer and quieter WITHOUT feeling dumb or sad. And I don't seem to be quite as ravenously hungry as on Seroquel. Hope it lasts!
Saphris is the best. 10/10. For those of you who had bad experience starting out, I suggest trying it out again from a low dose. The key is to get the medicine in your system until it builds up in a few week. When all else failed Saphris was the one that had saved my life and improved it like it has reversed the chemical imbalances associated with my bipolar. My mind and sense of attention has been brought back from the severe depressed and mixed episode. And severe agitation. When I first started Saphris with 5mg it too gave me severe akathesia (restlessness). Thank fully after finding out that my other medication mirtazapine (Remeron) reduced restlessness. I can now sleep well after taking the Saphris with the Remeron without any insomnia.
I have Bipolar I with some psychotic episodes in the past. I used to be on Abilify, but I had weight gain and shaking of my hands. Saphris has been wonderful for me. I used to take Ambien because I couldn't sleep, but with Saphris I fall asleep within 10-15 minutes. I only take 5mg at night. I don't take it in the morning because of how sleepy it makes me. I've also tried 10mg at night and that worked well too. As for the flavor, I have to have the black cherry. I couldn't stand the original, mint, I think it was. I feel great and would definitely recommend it.
25 users found this comment helpful.
I love this medicine. I have Bipolar 2 and post traumatic stress disorder. I have been on this medicine for 9 months. It puts me to sleep about 15 mins after taking it. I have lost 35 pounds (I had gained 50 pounds on Lamictal and Abilify) I am off the Lamictal. I have been able to stay out of the hospital. I feel better overall. I am trying taking 1 course in college and may even try to work again.
20 users found this comment helpful.
I was very hopeful when starting Saphris, but it didn't take long for my family and I to see this was NOT the medication for me. I asked doctors to take me of this but I kept on being told to give it more time. I would sleep over 12 hours a day and if I could SOMEHOW manage to stay up with the use of coffee and energy drinks, I was a shell. I would sit there confused, unable to really talk or take care of myself. I took it twice a day once in the morning and once before bed, and rather than give me my life it was robbing me of what little I had.
It also didn't help with my delusions or paranoid thinking. I even still saw shadows and things of that nature from time to time.
12 users found this comment helpful.
Review by Anonymous (taken for 6 months to 1 year):
I responded well to this medicine but I gained 50 pounds and was tortured by unending hunger. Eventually I had to get off of it and that wasn't easy. It took about a month to get over the withdrawal symptoms.
I have been taking Saphris for 10 days. I went cold turkey off Seroquel 600mg/day. I have had terrible insomnia. My psych said this should improve over next few weeks, I hope so. Agreed that it tastes awful and numbness under tongue only lasts approx half an hour. My mood improved the next day after my first 5mg dose. I feel so happy and enthusiastic about life, which is amazing. The Seroquel fog has lifted and I have lost 3.5kgs in 7 days (Seroquel munchies are gone).
17 users found this comment helpful.
Review by Branheckman (taken for 6 months to 1 year):
My experience on Saphris has been mixed. None of the other atypical antipsychotics has addressed my manic symptoms better. It really helps with my sleep. My moods are more stabler, I'm less of a trouble/burden for my family, and I'm happier than I've been in the past. Now the problems: First, when I'm on Saphris, it lowers my sex and creative drives. I've had trouble in bed, and I've found it really difficult to generate new ideas for paintings and drawings, and the quality of my art overall has decreased. Second, Saphris appears to be impacting my long-term memory. My spouse has noticed this. I'm just not remembering my past with reliability--memories are faint and/or scrambled and I usually get details and dates wrong.
12 users found this comment helpful.
I began taking Saphris for the purpose of helping me sleep. I took it "as needed" as originally instructed. At first, it seemed to help me fall asleep and shut off the constant whirl of my brain at night. When I began taking it nightly and increasing my dosage, as instructed, to 10 mg rather than 5 mg, (I was instructed to take it all at once), I began to get a very itchy and painful rash. One patch is very red and inflamed and about the size of a silver dollar. I also began to notice that the noise in my brain at night worsened to a hypomanic state. I have insomnia now, instead of sleeping well as I was when first taking it. I've also had migraines. I don't know if this is all connected to Saphris.
I have been severely depressed since birth of my child 5 years ago. I have been put on every medication out for depression and mood stability. This medicine is the best. I have not felt this good in years.
17 users found this comment helpful.
I just found out I have bipolar and also maybe skitzo efftive not sure how u spell that. Anyways my thinking process was horrible and I took this medicine and the FIRST day I noticed a huge difference for the first time in a while I felt like a normal person! It was amazing! Side effects I've had were numbness of toungue and bad taste (which aren't bad) but I do sometimes wake up in the middle of the night feeling like my legs are asleep or tingling. But that was the first night I took it and the first time I updosed my medicine I hope that ain't a bad thing and it goes away because other than that its AWESOME!
Thanks to this forum I decided to give Saphris a try. Have previously been on Zoloft and later on Pristiq with zero effect and awful side effects. I was very hesitant to try a new medication but did some research, and was so surprised to see the positive feedback.
Have only been on Saphris for 10 days, but the improvement has been immediate with virtually zero side effects. Within an hour of taking 5mg Saphris I can feel the calming effect. Mood swings have been a lot less, and the panic reduced dramatically. If you drink alcohol, make sure you take Saphris in the morning before you have any alcohol later on in the day otherwise the "hangover" is real bad.
If in doubt, this could be the one! Give it a try.
15 users found this comment helpful.
I recently wrote when I was 2 weeks in, now I'm going on week 4. I'm still feeling pretty well. I seem to be able to get a lot accomplished now, I did before but was always overwhelmed with it. I'm no longer overwhelmed. The worst side effect of this medicine, in my opinion, is being sleepy. It knocks me out within a few minutes of taking it. Other that that no other issues.
11 users found this comment helpful.
I was very hesitant to start taking this medicine. I have tried so many different kinds before and they had done more damage than good. I read a lot of the reviews on here and after serious thought I decided to try it. I'm so very happy I did. I'm about two weeks in and I believe I have found the correct mix. I'm so happy, and excited! It's almost hard to believe. If anyone is on the fence about this I would recommend taking it. If you trust your psych doc, I would assume you do then go for it. I was told you can tell the next day if you should stop taking it. I have Bipolar 1 disorder and I also take Wellbutrin XL 150mg 3 x a day. Klonopin 4 x a day and now Saphris 5 mg at night. I love it!
13 users found this comment helpful.
I was diagnosed with a mood disorder about 5 months ago. I tried Abilify and gained 10 pounds in a week and tried Lamictal but I kept getting the rash on my face, so finally my doctor put me on Saphris. It made a world of difference. It's been 2 months now and I'm no longer on any antidepressants and I have been without any depressed episodes since a week after I started it. I had to start taking 20 mg at night because it made me so tired in the morning. I'm still on Klonopin because I have really bad restlessness still, but I'm slowly phasing that out with lifestyle changes. The bad taste gets better with time and the side effects are greatly outweighed by the benefits. I have and would recommend it!
14 users found this comment helpful.
I was prescribed this for Bipolar I. I am also taking Lexapro. Taking this sublingually is a pain, mainly because it tastes horrible. I am also convinced that this medicine caused the severe panic attacks I was having, which seemed dose-dependent (I was on both 5 and 10 mg of Saphris). Upon first taking the medicine, I would get severe restless legs that would last for about 3 hours. The medicine makes me very drowsy, but it was hard to sleep with severely restless legs. This side effect went away after about a week.
10 users found this comment helpful.
My insurance covers the whole cost of the medicine thank goodness, otherwise it would cost over $700 per month. I only rated it an 8 because even though it works wonderfully to completely wipe away my depression by taking my required dose of 5mg once at night and once in the morning, I cannot seem to fight off the sleep in the morning even if I take it right when I wake up. When I can fight off the sleep I am so tired that I feel sedated for about 6 hours. The taste is awful but bearable. I just don't know what to do about my morning dose. It makes me hungry but the downside is that if I eat within 4 hours of taking Saphris it is a little hard to swallow my food and I do get a tingling numb tongue for about an hour after taking medicine.
I have been on 20mg Saphris for 4 weeks, after taking 10mg for three weeks. I wish I had the amazing results you people have had. I would love to have the happy feelings you speak of. After seven weeks I still have a dazed feeling and difficulty processing information. I am waiting for my depression to lift. I take other mood stabilizers including lithium. I'm afraid Saphris may be yet another failed attempt for me. The nasty taste and numb tongue are little bother for me, if it would just work.
Saphris has been a literal life changer for me. I have tried antidepressants in conjunction with mood stabilizers such as lithium and Depakote. I was combating severe depression and mania. When I first started Saphris, I was suicidal and had awful thoughts constantly. Nothing was working. I was on 1000mg of Depakote, which was as high as I could go due to my low body weight. My psychiatrist, who was the 4th psychiatrist I had seen in 6 months, added Saphris to my regimen of Depakote, 30mg of Remeron, and 10mg of Ambien for sleep. Within just a couple of days I felt GREAT! All the bad thoughts disappeared, I no longer want to die, and this medicine did not take away my (manic)creative energy like most other antipsychotics do! MIRACLE for me!
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