The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Been bipolar for seventeen years, Saphris for two months, started out eating right after I took it and I was very sleepy. The eating eventually subsided but within ten days I started having jaw muscle tension. At first I had energy and the racing thoughts and paranoia went away. The sublingual dosing and taste seemed to be minor in the hopes that it would help symptoms. I would take it at night only, after getting everything done for the evening because it really made me sleep deeply, within fifteen minutes, when I really didn't have a sleeping problem before taking it. It did make me more alert during the day, which almost led to panic on several occasions. It was addressing psychosis symptoms but I continued a low level of depression
Saphris is the best bi-polar medication I have taken. I sleep the best I ever had on Saphris and do not experience manic out bursts. Other bi-polar medications made me gain weight. On other medications I have gained 30 lbs in a short time frame. On Saphris, I haven't gained any weight and weigh a few pounds less than I did before I started to take Saphris.
I have Bipolar Disorder I, with rapid cycling and mixed states. I tried Saphris when I was recovering from a hospitalization which was very unpleasant and ended very badly. So I was a bit manic and terribly anxious going on it. I took it for 6 days. It seemed to work almost right away. I was shakey and anxious throughout the 6 days. Extremely sleepy and dizzy after my 5mg at bedtime. But that wore off after 4 days. Mood-wise, it seemed to completely stall my cycling. Miracle! And I was much calmer and less reactive, but definitely awake during the days. Then after my 6th dose I noticed my lips were puffy, and my tongue was fatter, then my throat got tight = allergic reaction. Worked great until that!
I have been taking this for about 4 months now. While I admit I am awful at being consistent with new meds, I am blown away by how well Saphris has consistently toned down my impulsivity, irritation, edginess, suicidal ideations, and cycling depression.
Unlike antipsychotics such as lithium, this stuff did not turn me into a walking zombie. I am still able to feel elated, just not so much so that I lose control of myself.
Also it helps me have a regular sleeping pattern! I do not know how anyone can taking this in the morning as it knocks me out harder than ambien.
The downside of it is that I am experiencing secondary nocturnal enuresis :S It is something I have always struggled with and I would not expect others to experience this.
I am currently taking 1/4 of a 5 mg tablet (but started out on a 1/2 tablet) of Saphris at night. I am also on Lexapro, 10 mg for depression and anxiety. The combo works great. I have horrible insomnia/waking in the night on just Lexapro (or other SSRI's I've tried) but with Saphris I sleep great and wake up refreshed! Only downside is that I've put on 10-15 pounds in the last 6 months, but not sure if it is due to the Lexapro or Saphris or both. I eat very healthy (just too much) and exercise regularly....but find myself always feeling hungry. Oh well...at least I'm happy!
Saphris has helped me more than any other medication (which were many, many over 12 years). I was blown away by the benefit and bewildered that it took so long for someone to prescribe it. I still don't have the strength and energy that I need but I am functioning at 80% to 90%. Before it was barely hanging on with suicidal periods. Savella was another good medication for me but not quite this good. The racing thoughts, paranoia, and insomnia are gone. I usually fall asleep within 15 minutes of lying down. Although I am having some nights of waking up after 3 hours. Just getting to sleep earlier and getting the required sleep I need has made a tremendous difference in how I function and cope. My side effect has been arthritis and weight gain.
20 users found this comment helpful.
Review by Kissa miau (taken for less than 1 month):
I will give this a 2, simply because of the ease of use. The tabs dissolve under your tongue so you can take them anywhere. You cannot eat or drink for 10-15 min afterwards, which is really not a big deal.
I am bipolar I with occasional mixed episodes and was prescribed this medicine (5 mg 2x daily) in the middle of a mixed episode while in the hospital. It propelled me into full-blown mania.
As with all medicines and this disease, its very personal. This medicine might be more appropriate for someone less prone to mania than myself. I am on Topamax 150 mg (50 mg 3x daily) and Seroquel 100 mg nightly, now. I am not cured by a long shot, but I am certainly a lot better now, a month later, than I was on the Saphris.
I have tried so many medications for my numerous manic episodes and nothing even came close to the benefits I have experienced with Saphris. It reduced my anxiety and agitation profoundly. I have not had another episode after being on Saphris for over six months. I have an overall sense of well being and much more functional. I've lost 50lbs after being on Zyprexa. Saphris is a wonderful medicine and has given me hope and I am slowly rebuilding my life. It might taste really bad but it is all worth it.
41 users found this comment helpful.
You have to be aware of the positives and negatives of any medicine you take. Even Tylenol. I have found that Saphris has worked pretty well despite a few side effects that I've learned to live with. My doc tried me on Latuda first because I was a bit concerned with taking something sublingually. I should have tried Saphris first. Latuda had me wanting to jump out of my skin and made me want to eat all of the time. I gained 50 pounds in the six months I was on Latuda and have lost all but 7lbs on Saphris. I don't mind the numb tongue because it goes away. I am even used to the taste now. Overall Saphris gave me my life back.
36 users found this comment helpful.
Review by Anonymous (taken for less than 1 month):
I am Bipolar Type I and was switched to Saphris from Seroquel by my psychiatrist. One dose and I began having suicidal ideation that I hadn't experienced in years. I had the presence of mind to call my psych doc immediately (it was a weekend) but she didn't call back. I am a nurse and should have known better, but I took it the next day. After the second dose, I was frightened I would act on the impulse. Luckily I have a very supportive and observant husband. I called doc again and she said to stop immediately, of course, as I should have after the first dose. I saw her on Monday and went back to Seroquel. Less severe side effects included numbness of my entire tongue and sick-feeling somnolence.
15 users found this comment helpful.
I have had some success in using Saphris, however, the side effects are somewhat mixed. I don't like feeling groggy or fussy the morning after taking the medicines. I also don't like having short term memory loss. I like the stabilizing mental moods and the reduced depression and manic episodes. The medicine numbs my tongue and makes me hungry all the time, so am I hoping after time this stops. I have been taking this medication since the May, 20mg.
20 users found this comment helpful.
I love Saphris. Best thing that ever happened to me. No other medicine compares. Down side, it's so expensive. I get samples from my psychiatrist, but I will be moving out of state soon and I am so afraid I won't be able to afford Saphris. It's the only medicine that gave me the least amount of side effects and lets me lead a normal life.
30 users found this comment helpful.
I've been on Saphris 20mg nightly for 2 months. I have Bipolar Rapid Cyclical with ADHD. This medication is the best. I fall asleep within 10-15 minutes. The horrible taste is a small price to pay. My mood is the most stable it's been in a long time. I'm happy about life, feeling very positive- a huge change for me!
40 users found this comment helpful.
I was diagnosed with Bipolar Disorder almost five years ago and have tried just about every medication without success. I have recently started taking Saphris and it is my miracle. My mood swings have gone and I'm no longer angry or depressed. I have plenty of energy (minus the mania) and feel a complete sense of well being. The dissolvable wafers have a very bitter taste however this is a very small price to pay considering how awesome I feel.
39 users found this comment helpful.
Saphris has slowed my thoughts down a lot! I have the black cherry flavor. I do feel suicidal, but I felt that way before the meds. The only problem I have is the weight gain. I've been on Saphris for almost 2 months and have gained 20lbs. I find it hard to shed the weight.
22 users found this comment helpful.
I just replaced my 75mg nightly Seroquel with 5mg (will probably go to 10) of Saphris. I was very scared to change. I am a successful and happy trauma nurse, mom, partner, etc., even though I do struggle with bipolar disorder and anxiety. My life has been going REALLY well for several years with low doses of Seroquel, Zoloft, and Lamictal, so when my annual spring crazies kind of snuck up on me worse than normal, I was very hesitant to rock the boat. So far this compares VERY FAVORABLY with my Seroquel. I am sleeping well and the morning fog is getting better as my body adjusts. My thinking is clearer and quieter WITHOUT feeling dumb or sad. And I don't seem to be quite as ravenously hungry as on Seroquel. Hope it lasts!
38 users found this comment helpful.
Saphris is the best. 10/10. For those of you who had bad experience starting out, I suggest trying it out again from a low dose. The key is to get the medicine in your system until it builds up in a few week. When all else failed Saphris was the one that had saved my life and improved it like it has reversed the chemical imbalances associated with my bipolar. My mind and sense of attention has been brought back from the severe depressed and mixed episode. And severe agitation. When I first started Saphris with 5mg it too gave me severe akathesia (restlessness). Thank fully after finding out that my other medication mirtazapine (Remeron) reduced restlessness. I can now sleep well after taking the Saphris with the Remeron without any insomnia.
18 users found this comment helpful.
I have Bipolar I with some psychotic episodes in the past. I used to be on Abilify, but I had weight gain and shaking of my hands. Saphris has been wonderful for me. I used to take Ambien because I couldn't sleep, but with Saphris I fall asleep within 10-15 minutes. I only take 5mg at night. I don't take it in the morning because of how sleepy it makes me. I've also tried 10mg at night and that worked well too. As for the flavor, I have to have the black cherry. I couldn't stand the original, mint, I think it was. I feel great and would definitely recommend it.
48 users found this comment helpful.
I love this medicine. I have Bipolar 2 and post traumatic stress disorder. I have been on this medicine for 9 months. It puts me to sleep about 15 mins after taking it. I have lost 35 pounds (I had gained 50 pounds on Lamictal and Abilify) I am off the Lamictal. I have been able to stay out of the hospital. I feel better overall. I am trying taking 1 course in college and may even try to work again.
41 users found this comment helpful.
I was very hopeful when starting Saphris, but it didn't take long for my family and I to see this was NOT the medication for me. I asked doctors to take me of this but I kept on being told to give it more time. I would sleep over 12 hours a day and if I could SOMEHOW manage to stay up with the use of coffee and energy drinks, I was a shell. I would sit there confused, unable to really talk or take care of myself. I took it twice a day once in the morning and once before bed, and rather than give me my life it was robbing me of what little I had.
It also didn't help with my delusions or paranoid thinking. I even still saw shadows and things of that nature from time to time.
23 users found this comment helpful.
Review by Anonymous (taken for 6 months to 1 year):
I responded well to this medicine but I gained 50 pounds and was tortured by unending hunger. Eventually I had to get off of it and that wasn't easy. It took about a month to get over the withdrawal symptoms.
18 users found this comment helpful.
I have been taking Saphris for 10 days. I went cold turkey off Seroquel 600mg/day. I have had terrible insomnia. My psych said this should improve over next few weeks, I hope so. Agreed that it tastes awful and numbness under tongue only lasts approx half an hour. My mood improved the next day after my first 5mg dose. I feel so happy and enthusiastic about life, which is amazing. The Seroquel fog has lifted and I have lost 3.5kgs in 7 days (Seroquel munchies are gone).
27 users found this comment helpful.
Review by Branheckman (taken for 6 months to 1 year):
My experience on Saphris has been mixed. None of the other atypical antipsychotics has addressed my manic symptoms better. It really helps with my sleep. My moods are more stabler, I'm less of a trouble/burden for my family, and I'm happier than I've been in the past. Now the problems: First, when I'm on Saphris, it lowers my sex and creative drives. I've had trouble in bed, and I've found it really difficult to generate new ideas for paintings and drawings, and the quality of my art overall has decreased. Second, Saphris appears to be impacting my long-term memory. My spouse has noticed this. I'm just not remembering my past with reliability--memories are faint and/or scrambled and I usually get details and dates wrong.
21 users found this comment helpful.
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