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March 2007

March 1

Pharmacopeia to Present Highlights From the Company's DARA Program at the R. Bryan Miller Memorial Symposium Genelabs Announces Publication in New England Journal of Medicine of Clinical Trial Results with Hepatitis E Virus Vaccine Pluristem Announces Scientific Advance in Stem Cell Research; Evidence That PLX Cells Are Immunosuppressive CollaGenex Pharmaceuticals Announces Positive Results of Phase 2 Dose-Finding Study of Incyclinide for the Treatment of Acne Lowest FDA-Approved Dosage of Estradiol to Significantly Reduce Hot Flashes Reported in Newly-Published Study Affibody Molecules for Cancer Imaging Made by Chemical Synthesis Excerpt of SEC Filnig by Amgen, Inc. Study Published in New England Journal of Medicine: Vaccine 95.5% Effective Against Neglected Hepatitis E AVI BioPharma Presents Novel HIV Drug Candidate Results Lorus Therapeutics Announces a Key Scientific Publication on Therapeutic siRNA in Cancer Therapy MAP Pharmaceuticals Reports Positive Phase 2 Results for its Inhaled Migraine Drug Candidate Schizophrenia Drug Studies: One Size Does Not Fit All; Community Services Also Needed New Details in Schizophrenia Treatment Trial Emerge New Global Survey Shows Effective Patient-Physician Communication Critical to Accurate and Timely Recognition of Neuropathic Pain Idenix Announces Thirteen Data Presentations at the 2007 European Association For the Study of the Liver Lorus Therapeutics Announces a Key Scientific Publication on Therapeutic siRNA in Cancer Therapy Results with New Integrase Inhibitor Plus Fuzeon and Boosted Protease Inhibitor Show Remarkable Undetectable Rate of 98 Percent in Treatment-Experienced HIV Patients Hepatitis Foundation International: New Study Supports Effectiveness of Liver Wellness Education Pfizer's Maraviroc, Novel Medicine For HIV, Significantly Reduces Viral Load, in Combination Therapy Across Range of Treatment-Experienced Patients New Data on Investigational Agent TMC278 in Anitretroviral-Naive HIV Patients New Joslin Study Reveals How a Specific Fat Type Can Protect Against Weight Gain and Diabetes Results from Two Phase III Studies on Isentress (raltegravir, MK-0518), Merck's Oral Investigational Integrase Inhibitor Presented at the Annual Conference on Retroviruses and Opportunistic Infections (CROI) Monogram Provides Update on Trofile Assay - Pfizer Reports Significant Reduction in Viral Load in Clinical Trial of Maraviroc

March 5

LAB International Announces Positive Results from the Open-Label Phase IIb Fentanyl Taifun Trial - New Patent Application Submitted New Studies Indicate GSK's Pre-Pandemic Influenza Vaccine Can Protect Against Different Strains of H5N1 Phenomix Completes Phase 2a Clinical Trial - Diabetes Drug is Efficacious and Well Tolerated Memory Pharmaceuticals Reports Phase 2a Results for MEM 1003 in Bipolar Disorder Transition Therapeutics Announces Positive Data from E1-I.N.T. Clinical Trials in Type 1 and Type 2 Diabetes Patients Collegium Pharmaceutical Announces Successful Completion of Proof of Concept Clinical Trial for Novel Combination Allergic Rhinitis Product Iomai Vaccine for Travelers' Diarrhea Blunts Severity of Disease in Clinical Study Study Shows Nonsurgical Treatment Reduces Neck Pain Without Significant Risk of Paralysis Myriad Presents Additional Flurizan Phase 2 Study Data Demonstrating Benefit in Alzheimer's Patients Study Examines Genetic Risk Factors for Alzheimer's Disease Cytheris Releases Promising Clinical Data on its Interleukin-7 Immune Enhancer at the 2007 CROI Meeting in Los Angeles Helix Biopharma to Present L-DOS47 Lung Cancer Research Findings at the Fourth International Conference on Tumor Microenvironment in Florence, Italy

March 7

CeNeS Pharmaceuticals plc: Update on Successful Phase III results announced on Lead Product M6G Actelion  Announces Positive Study with Bosentan (Tracleer) in CTEPH CV Therapeutics Announces Topline MERLIN TIMI-36 Results Acambis Announces Appointment of New Chief Executive Officer and Other Senior Management Changes American Society of Clinical Oncology (ASCO) Accepts New Data on AVR118 for Publication in 2007 Abstract Book BioLineRx Presents Data on BL-1040 at Cardiovascular Revascularization Therapies Conference Demonstrating Potential to Reduce Deterioration of Infarcted Heart Tissue and Maintain Functionality Gemin X Announces Publication of Preclinical Data of GX15-070 in Multiple Myeloma in Blood Accentia Biopharmaceuticals Scientific Presentations Demonstrate Increasing Acceptance of Fungal Etiology of Chronic Sinusitis at the Annual Meeting of the American Academy of Allergy, Asthma, and Immunology Major Gene Study Uncovers Secrets of Leukemia British Journal of Cancer Reports Preclinical Evidence of Positive Effect of Rice Bran on Intestinal Cancer

March 8

Hollis-Eden Announces Cancellation of Acute Radiation Syndrome RFP by Department of Health and Human Services La Jolla Pharmaceutical Announces Positive Interim Antibody Results From Riquent Lupus Phase 3 Trial Arpida adds novel antibiotic AR-2474 to its preclinical pipeline Antisoma plc (UK) - Second lung cancer trial adds to positive data on AS1404 Data From Adherex's European Phase Ib/II Trial of ADH-1 to be Presented at International Symposium on Targeted Anticancer Therapies IR BioSciences Announces Data Demonstrating Radilex Stimulation of Stem Cells Results in Hematopoietic Recovery Following Lethal Irradiation Newly Released Canadian Data Links Vaccines with Pervasive Developmental Disorder Study in Cell by Magen BioSciences Co-Founder David E. Fisher Identifies New Roles in Skin Cancer Prevention for Key Tumor Suppressor Protein Weight Management is Not Enough for Cannabinoid Type 1 (CB1) Receptor Antagonists to Become a Commercial Success Scottish Scientists Test ‘Secret Weapon’ Against Tumours Why Is Polio Spreading in Pakistan?

March 12

Chemokine Therapeutics Announces Preliminary Results of CTCE-9908 Phase Ib/II Clinical Trial in Late Stage Cancer Patients Primary Endpoint Met in Phase 2 Trial of Daclizumab in Patients With Relapsing Multiple Sclerosis Preclinical Update - Debio-0512 Therapeutic Vaccine for the Treatment of Chronic and Acute Inflammatory Conditions GenoMed Prevents Sickle Cell Pain for Over a Year Schering-Plough Announces Presentation of Phase II Trial Results for Novel Oral Thrombin Receptor Antagonist at the 2007 Annual Meeting of The American College of Cardiology/i2 Summit Ceragenix Announces Ceragenins Virtually Prevent Catheter Biofilm Formation in 21 Day Study Integrated Biopharma's Proprietary Vaccine Technology Achieves Strong Positive Results Integrated BioPharma's Proprietary Vaccine Technology Achieves Strong Positive Results PI-88 Data to be Presented at Key International Conferences

March 19

Coronary Artery Disease ARISE Trial Showed AGI-1067 Did Not Meet Primary Endpoint Acorda Therapeutics Presentation of Fampridine-SR Phase 3 Data Selected for Scientific Highlights Program at the American Academy of Neurology Meeting New Phase IV Clinical Study Indicates LidoSite Provides Rheumatology Patients Superior Pain Relief Seroquel Sustained Release Schizophrenia Data Presented at ECP Congress in Madrid In New Study, Duloxetine Reduced Non-specific Pain and Emotional Symptoms Associated with Depression Acadia Announces Positive Results From ACP-103 Phase II Schizophrenia Co-Therapy Trial Abbott to Present New Data Across its Vascular Portfolio at the American College of Cardiology's 56th Annual Scientific Session AtheroGenics Reports ARISE Trial Results for AGI-1067 Avid Announces Results of AV-1 Molecular Imaging Agent for Alzheimer's Disease Presented at AD/PD Meeting Nymox Announces Positive Results from Newly Completed Long-term Study of NX-1207 for Benign Prostatic Hyperplasia Nuvelo Announces Presentation on rNAPc2 at American College of Cardiology 56th Annual Scientific Session Medivation Announces Presentation of Full Top-Line Data From Dimebon Six-Month Trial at Major International Alzheimer's Disease Conference Amicus Therapeutics Presents Data From Preclinical and Phase 1 Studies of Amigal for Fabry Disease

March 20

Calando Pharmaceuticals Publishes the First Non-Human Primate Study on Targeted, Systemic Delivery of siRNA in National Academy of Sciences Journal Arrowhead Subsidiary, Calando Pharmaceuticals Publishes Study on Targeted, Systemic Delivery of siRNA MGI Pharma Announces Positive Results from a Pivotal Phase 3 Study of Aquavan Injection in Patients Undergoing Bronchoscopy La Jolla Pharmaceutical Provides Update on Interim Antibody Results From Riquent Lupus Phase 3 Trial Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor Data Showing Broad Anti-Tumor Activity, Dosing Flexibility ImmuneRegen BioSciences Announces Promising Data on Homspera Suggesting Potential as a Co-Therapeutic Agent Dharma Therapeutics Shows IDDS Is Effective in Reducing Pain Associated With Insertion of an Intravenous Catheter in Their Phase 2 Clinical Trial REACH Registry Demonstrates That Multiple Arterial Disease Locations Sharply Increase the Risk of Major CV Events in Outpatients With Atherothrombosis Corcept Therapeutics Announces Phase 3 Study Evaluating Corlux for Psychotic Major Depression Misses Primary Endpoint Hospitalization Rates for Coronary Artery Disease Decline in the U.S. Avexa Reports Positive Phase IIb Result Amicus Therapeutics Presents Preclinical Data from Studies of Plicera for Gaucher Disease Alfacell's Onconase Highlighted in Latest Edition of Handbook of Therapeutic Antibodies New Data from the US and Japan Support: No Established Causal Link Between Neuropsychiatric Symptoms and Treatment with Tamiflu US Databases Indicate Psychiatric Symptoms Lower in Influenza Patients Taking Tamiflu Versus Those Not Taking Tamiflu Researchers Find Surprising Pattern of Influenza Spread in South America and Tropics Protein Found to Shield Pancreatic Cancer Cells from Self-Destruction Protox Announces Publication in Journal of the National Cancer Institute Supporting PRX302 as Treatment for Prostatic Diseases

March 22

AEterna Zentaris Reports Positive Results with Cetrorelix in BPH for Japanese Phase 2a Trial Isis Pharmaceuticals Announces Its Participation at the Upcoming ACC 56th Annual Scientific Session in New Orleans and Its Live Analyst/Investor Webcast Presentation Additional Data From Satraplatin SPARC Phase 3 Trial Presented at European Association of Urology Congress Nutra Pharma Announces Publication of Research on Treatment for Multiple Sclerosis Aeolus Pharmaceuticals Announces Successful Completion of Multiple Dose Safety Study of AEOL 10150 Laresse Dermal Filler Research Presented at Anti-Aging World Congress Studies Show Mild Hyperthermia Enhances Antitumor Effects of Alfacell's Onconase Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity

March 26

Abbott's Xience V Everolimus Eluting Coronary Stent Superior to Taxus Stent in Spirit III U.S. Pivotal Clinical Trial New Clinical Data for Cytogen's Quadramet and Prostacint to be Reported at Upcoming Major Medical Meetings EntreMed Presents Mechanism Data for Its Three Lead Oncology Compounds First Study To Show Positive Benefit On Atherosclerosis For People With Early Signs Of Diseased Arteries Abbott Announces Positive Six-Month Results From the World's First Clinical Trial of a Fully Bioabsorbable Drug-Eluting Coronary Stent Inovio Biomedical's DNA Delivery Technology Significantly Enhances Potency of HIV DNA Vaccine Inimex Product Candidate is First Immune Defense Regulator to Cure Infections Without Causing Harmful Inflammation In vivo Study Results Demonstrating Potential of Alfacell's Onconase for Treatment of Non-Small Cell Lung Cancer Published in Anticancer Research Everest Data on Short- and Long-Term Use of Otsuka's Investigational Novel Treatment, Tolvaptan, Published in Journal of the American Medical Association and Featured in ACC's Late Breaking Clinical Trials Scios Announces Results From Exploratory Nesiritide Study Providing Important New Renal and Mortality Safety Data with a Neutral Effect on the Primary Endpoint Cholesterol Drug Fails to Slow Progression of Coronary Disease, Cleveland Clinic Study Reports Study Presented at the ACC Shows Inflammatory Enzyme Lp-PLA2 Predicts Heart Disease Risk in Metabolic Syndrome Patients Tekturna, First New Type of High Blood Pressure Medicine in a Decade, Provides Additional Blood Pressure Reduction When Used With Diovan Isis Pharmaceuticals Reports Positive Phase 2 Data for ISIS 301012 in Familial Hypercholesterolemia Patients Presented at ACC Diobex Announces Successful Completion of Phase 2a Trial Of DIO-902, a Novel Cortisol Synthesis Inhibitor for Type 2 Diabetes Study: Identical Doses of BiDil Components Are Not Bioequivalent to the Fixed Dose Combination-BiDil-Used in A-HeFT Two New Imaging Studies Show Higher Dose Lipitor Stopped the Progression of Atherosclerosis Cypher Sirolimus-eluting Coronary Stent Had Similar Results to Bypass Surgery in Long-Term Study of Patients With Multi-Vessel Coronary Artery Disease Two-Year Results from the Medtronic ENDEAVOR III Trial Confirm Stent's Positive Clinical Profile CSL Therapy That Mimics 'Good' Cholesterol May Reduce Plaque Volume in Coronary Arteries Two Abbott Studies Reaffirm Carotid Artery Stenting as a Safe and Effective Treatment to Reduce Risk of Stroke Alexza's AZ-004 Phase IIa Trial Meets Primary Endpoint in Treating Schizophrenic Patients With Acute Agitation Acuity One-Year Findings Meet All Primary Endpoints in Favor of Angiomax (Bivalirudin) Alone Treatment Group Calcium Plaque Build-up in the Arteries Leads to Coronary Heart Disease in Multi-Ethnic Groups Two-Year Patient Registry Results Support Safety and Efficacy of Cypher Sirolimus-Eluting Coronary Stent in 'Real World' Uses

March 27

Rigel Ubiquitin Ligase Program Identifies Molecules With Anti-HIV Activity Afid Therapeutics Obtains Positive Evaluation of its Triple Mode Viral Sequestration Agents Landmark Findings From ECLIPSE Program Show Improved Control of Perioperative Hypertension Reduces Risk of Death In Cardiac Surgery Positive Interim Phase 2 Data Reported for VEGF Trap-Eye in Age-Related Macular Degeneration Study Presented at ACC Shows Treatment With ISIS 301012 Added to Statins for Only 5 Weeks Results in 75% of Patients Achieving LDL-C Levels Less Than 100 mg/dL and 50% of Patients Achieving LDL-C Levels of Less Than 70 mg/dL MediciNova Announces Positive Clinical Results From MN-166 Phase II Multiple Sclerosis Trial Lipitor Provides Unprecedented Cardiovascular Risk Reductions in Diabetes Patients with Metabolic Syndrome and in Stroke Patients PC-DAC:Exendin-4 Phase I/II Multiple-Dose Study Preliminary Results Demonstrate Safety and Efficacy at Once-Weekly Dosing CombinatoRx Provides Topline Results from Phase 2 RA Study with CRx-139 and Very Low Dose Prednisolone Survey Reveals Significant Public Lack of Diabetes Awareness Curecumin May Be an Effective Treatment for Lung Cancer Interferon Beta DNA Treatment Delivered with Ichor Technology Reduces Atherosclerosis Progression in Mice Isotechnika's independent data monitoring committee conducts review of phase 2b kidney transplant trial Pivotal Phase III Findings With Investigational Drug Cleviprex (Clevidipine) Demonstrate Perioperative Blood Pressure Control In Cardiac Surgery Lipitor Significantly Lowered Hospitalization Costs for Patients with Heart Disease, Two New Analyses Show Inotek Pharmaceuticals Announces Presentation of Phase 2 Clinical Data for INO-1001 at ACC Demonstrating PARP Inhibition and Anti-inflammatory Activity in Plasma of Patients Undergoing Primary Percutaneous Coronary Intervention Heart Attack Patients Treated With Novel Stem Cell Therapy Experience Significant Improvement in Heart and Lung Function Increasing Proportion of Cardiovascular Disease Due to Diabetes Over the Last 50 Years

March 28

ACC Presentation Indicates Interleukin-1 Gene Variants Determine Increased Risk for Coronary Artery Disease from Oxidized Phospholipids Ace Biosciences, Ace393, the World's First Commercial Vaccine for Travellers' Diarrhoea Caused by Campylobacter Successfully Completes Phase I Clinical Trials Calcium Channel Blocker Adalat GITS Offer Additional Benefits CSL Therapy That Mimics “Good” Cholesterol May Reduce Plaque Volume in Coronary Arteries Biosite Reports on Presentation of Preliminary Data From Sepsis Program CeNeS Pharmaceuticals Plc Announces Preliminary Results for The Year Ending 31 December 2006 Diabetes Linked to Higher Parkinson's Risk Dong-A PharmTech Co., Ltd. Announces Positive Results for Udenafil, Its New Long Acting Drug For Erectile Dysfunction MRI Detects Cancers in the Opposite Breast of Women Newly Diagnosed with Breast Cancer New Study Confirms Role for Pertussis Immunization of Entire Family in Reducing Infant Pertussis

March 29

Preclinical Data on Cytogen's Technology to be Reported at the AACR Annual Meeting Arpida Announces Promising Results of "First-In-Man" Studies With AR-709 Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery of GLP-1 and PYY Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic Effect in New Primate Model of Established Anthrax Infection Pieris Demonstrates Potent Anti-Tumor Activity of a VEGF-Specific Anticalin in Preclinical Studies ADVENTRX to Present CoFactor Multiagent Therapy Data at AACR Annual Meeting Baxter Announces Final Phase I/II Data and Initiation of Phase III Clinical Trial for Candidate Pandemic H5N1 Influenza Vaccine Portola Pharmaceuticals Presents Positive Phase I Data of Its ADP Receptor Antagonist at the American College of Cardiology Orapred ODT Tastes Good Mymetics' HIV Vaccine Achieves Research Breakthrough, Eliciting Protective Antibody Response in Mucosal Tissues of Non-Human Primate Model ACADIA Pharmaceuticals' Schizophrenia Programs to Be Presented at the 2007 International Congress on Schizophrenia Research Study Sheds Light on Medication Treatment Options for Bipolar Disorder Anthrax Monoclonal Antibody Valortim(tm) Demonstrates Therapeutic Effect in New Primate Model of Established Anthrax Infection

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