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February 2009

February 3

InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Phase III Study Showed Tarceva in Combination With Avastin as First-Line Maintenance Therapy Improved Progression-Free Survival in Advanced Lung Cancer InterMune to Announce Results of Phase 3 CAPACITY Program of Pirfenidone in IPF Tomorrow, February 3 Merck’s Safinamide Significantly Improved Motor Function in Patients with Advanced Parkinson’s Disease in a Phase III Pivotal Trial Results From Phase 2 Clinical Study of 6R-BH4 in Peripheral Arterial Disease Not Statistically Significant Rigel Expects R788 Partnership After Phase 2b Clinical Trials Results Senesco Announces Results of Pre-Clinical Efficacy, Toxicology and Dose Ranging Studies for Multiple Myeloma Therapeutic Candidate Medgenics Announces Positive Data From Phase I/II Clinical Trial of EPODURE Treatment of Anemia in Chronic Kidney Disease Gene Therapy Field Advances With Important Clinical Findings Reported in the New England Journal of Medicine PhytoMedical's Patented Anti-Cancer Compound Eradicates Tumor in Successful In-Vivo Tests against Human Brain Cancer AngioGenex Presents Data on its Id Targeted Anti-Angiogenesis Inhibitors at Two Scientific Conferences

February 5

New Evidence of Hormone Therapy Causing Breast Cancer, Stanford Professor Says BioDelivery Sciences Announces Initial Results of Phase 1 Clinical Study of Bioral Amphotericin B Interim Results From the MIRACEL Study Now Reported In the Renal Anaemia Disease Knowledge Centre at EPG Online Sopherion Therapeutics, LLC Announces Publication of Phase I/II Myocet (Nonpegylated Liposomal Doxorubicin) Data in Advanced Breast Cancer Patients Physicians from the Burzynski Clinic Present Initial Results of Combination Gene-Targeting Therapies on Advanced Pancreatic and Liver Cancers Minocycline/Rifampin-Impregnated Catheters Proven Clinically Effective in Preventing and Combating Potentially Fatal Bloodstream Infections in Two New Studies HemCon Medical Technologies, Inc. Announces Promising Results from Live Nail Infection Anti-Fungal Study Technology Platform Offers Tested Solution to Fungal Care Market

February 9

M. D. Anderson Study Finds Pregnancy Has No Impact on Breast Cancer Survival, Does Delay Treatment, Diagnosis Benitec Limited (ASX:BLT) City of Hope Human HIV Trial Update Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study Anti-HIV Gel Shows Promise in Large-Scale Study in Women ViroPharma Reports Results of Phase 3 Clinical Trial for Maribavir in Bone Marrow Transplant Patients MS Patients Treated with Tysabri Remain Free of Disease Activity for Two Years, According to Data Published in the Lancet Neurology EntreMed Presents Initial Clinical Results for ENMD-2076 New PRO2000 HIV-Prevention Findings Important Milestone on Path Toward Development of Effective Vaginal Microbicide Winston Pharmaceuticals Announces Positive Top-line Results of Phase I Clinical Trial of Civamide Patch Prism Pharmaceuticals' Study of Injectable Clopidogrel Accepted for Presentation at the American College of Cardiology

February 10

ConjuChem reports final data confirming PC-DAC:Exendin-4 lowers glucose and weight in Phase II diabetes trials Starpharma Holdings Limited (ASX:SPL) Topical Microbicide Field Receives a Boost with Human Efficacy Result Theratechnologies presents data at CROI Phase III Studies Showed Isentress in Combination Therapy Provided Significant Viral Load Reductions Through 96 Weeks in Treatment-Experienced Patients with Triple-Class Resistant HIV Data from Isentress, Merck's HIV Integrase Inhibitor, in Patients Whose HIV is Controlled on a Lopinavir/Ritonavir-Based Therapy Presented at the 16th Conference on Retroviruses and Opportunistic Infections Genaera Presents Preliminary Phase 1b Data for Trodusquemine (MSI-1436) Study Demonstrates Restylane Effect Lasted 18 Months in 97% of Patients With One Repeat Injection Nature Reviews Publishes Article About Jennerex's Multi-Mechanistic Cancer Therapeutic

February 12

La Jolla Pharmaceutical Company Announces Negative Results of Interim Efficacy Analysis for Riquent Phase 3 ASPEN Trial Zometa Reduces Risk of Breast Cancer Recurrence in Premenopausal Women, Study in The New England Journal of Medicine Reports Results of First Interim Efficacy Analysis for Riquent Phase 3 ASPEN Trial: Continuation of the Trial is Futile Alnylam and Collaborators Present Data from Multiple Pre-Clinical and Clinical Programs at RNAi Keystone Symposium New England Journal of Medicine Publishes Results From the Landmark ATHENA Trial with Multaq (dronedarone) in Atrial Fibrillation Osiris Reports Positive Two-Year Data on Stem Cell Treatment for Acute Myocardial Infarction GenoMed's Results Supported by Canadian Study: Dose is Key! Hope for 14 Million Rosacea Sufferers: Pyratine-XR Study to be Presented at South Beach Symposium Charleston Conducts Evaluation of an Opioid Symptoms Questionnaire Promising medical news for atrial fibrillation patients

February 17

Shionogi Announces Positive Top-Line Efficacy Results from Year-Long Studies of Velneperit, a Novel NPY Y5 Receptor Antagonist Being Investigated for the Treatment of Obesity Update of Long-Term Data on Brain Cancer Patients Receiving DCVax-Brain Continues to Show Striking Improvements in Delay of Disease and Survival IMPACT Study Demonstrates That Longer Prophylactic Therapy With Valcyte (Valganciclovir Hydrochloride Tablets) Increases Protection Against CMV - the Most Serious Viral Infection Affecting Transplant Patients BioSante Pharmaceuticals, Inc. Presents LibiGel Clinical and Market Information at ISSWSH Conference Novavax Presents Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program at World Health Organization Conference Groundbreaking Paper Publishes Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinson's Disease Pluristem Therapeutics to Present at Italian CREM Workshop Focused on Placental-Derived Cells Newly Published Menopause Study: 'Bioidentical' and FDA-Approved Divigel (estradiol gel) 0.1 Percent Safe and Effective Treatment for Moderate to Severe Hot Flashes Associated With Menopause University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene Transgene Confirms Longer Survival For Patients Treated With Tg4010 In Its Ongoing Phase IIb Non-Small Cell Lung Cancer Trial Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009 Romark Announces Presentation of New Data for Controlled Release Nitazoxanide in Chronic Hepatitis C Romark Announces Presentation of New Data for Controlled Release Nitazoxanide in Chronic Hepatitis C

February 18

High-Throughput Genotyping of AML Patients for a Key Immune Receptor May Significantly Improve Treatment Outcome Bioniche Phase II Bladder Cancer Trial Results Published in The Journal of Urology Compared To Standard Therapies, Pixantrone Decreases Time To Achieve Complete Remission By 47% In Relapsed Aggressive Non-Hodgkin's Lymphoma VGX Pharmaceuticals Proprietary DNA Vaccines Delivered with Electroporation Achieve Immune Responses Superior to Recombinant Adenovirus Serotype 5 (Ad5) Vectors Phase III Results in SOFIA Study of NPL-2008 iCo Therapeutics Oral Amphotericin B Published in Leading Journal Lancet Oncology: Epigenetic drug doubles survival in patients with 'preleukemia,' MDS Stanford Scientists Identify Drug to Treat Opioid Addiction Compared to Standard Therapies, Pixantrone Decreases Time to Achieve Complete Remission by 47% in Relapsed Aggressive Non-Hodgkin's Lymphoma KanekaQH Ubiquinol Dramatically Boosts Ejection Fraction in Patients With Late-Stage Congestive Heart Failure Data Published in The Lancet Oncology Further Substantiates VIDAZA's Extended Survival Benefit for MDS Patients

February 25

Adipose-Derived Stem and Regenerative Cells Prevent Mortality and Reduce Kidney Damage in Preclinical Study Bavarian Nordic reports further data on Prostvac Avigen Announces Positive Data for AV411 in Pain Relief and Drug Addiction PharmAthene Anthrax Protection Data Presented at ASM Biodefense Disease Meeting AVEO Pharmaceuticals' Oral, Triple VEGF Receptor Inhibitor AV-951 Shows Robust Activity in Patients with Advanced Kidney Cancer Hawaii Biotech Reports Phase 1 Results for West Nile Virus Vaccine Poniard Pharmaceuticals Announces New Efficacy and Safety Data from a Phase 2 Picoplatin Trial in Patients with Prostate Cancer Medivation Announces New Positive Efficacy Data From Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients New Cancer Treatment Stops Aggressive Sarcomas Medivation to Host Conference Call and Slide Presentation at 4:30 p.m. EST Wednesday, February 25, to Discuss New MDV3100 Efficacy and Safety Data From Trial in Castration-Resistant Prostate Cancer Patients

February 26

CPEX Pharmaceuticals Announces Completion of Phase 2 Trial for Urology Drug by Serenity Pharmaceuticals Optimer Pharmaceuticals Announces Publication in Peer-Reviewed Journal about Prulifloxacin's Antibacterial Activity against Infectious Diarrhea Producing Bacteria Archimedes Pharma Announces Successful Proof-of-Concept Results on Two Intranasal Development Projects Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data on KRX-0401 (Perifosine) in Combination with Bortezomib (+/- Dexamethasone) at the 12th International Multiple Myeloma Meeting DeveloGen AG (DE) - DeveloGen Reports Positive Phase 1 Clinical Trial Results for DG3173 RegeneRx Updates on Phase II Venous Stasis Trial   Crucell N.V. (NL) - Crucell's Revolutionary Antibody for Universal Therapy Against Flu Reproductive Factors May Protect Women from Parkinson's Disease Research Finding Could Revolutionize Asthma Treatment

February 27

Safety and Overall Survival Data in Docetaxel-Refractory Patients Enrolled in the Satraplatin SPARC Trial Being Presented at 2009 ASCO Genitourinary Cancers Symposium Safety and Overall Survival Data in Docetaxel-Refractory Patients Enrolled in the Satraplatin SPARC Trial Being Presented at 2009 ASCO Genitourinary Cancers Symposium BioInvent Presents Positive Preclinical Data for BI-505 in Myeloma Diabetes Patients With High Triglycerides and Low HDL Cholesterol get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study Mesoblast Limited (ASX:MSB) Presents Positive Adult Stem Cell Results To American Academy of Orthopedic Surgeons (AAOS) Cell Genesys Announces Final Results from Phase 3 Program of GVAX Immunotherapy for Prostate Cancer Cougar Biotechnology Announces Presentation of Positive CB7630 (Abiraterone Acetate) Phase II Data at ASCO 2009 Genitourinary Cancers Symposium Data Published in The Lancet Show Fampridine-SR Improved Walking Ability in People with Multiple Sclerosis Novagali Pharma Presents Results of its Innovative Latanoprost Formulation for Glaucoma Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer

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