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August 2007

August 2

Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) Encore Therapeutics Inc. (ETI) Reports Additional Proof of Concept Results on its Extended Release Ropivacaine Injectable Gel for Postoperative Pain Management Mayo Clinic News Release: "Wake-Up Pill" Under Study to Treat Patients with Bipolar Disorder Study provides hope for patients battling obesity and psoriasis Cobalis Reports PreHistin Demonstrates Significant Potential for Treatment of Vitamin B12 Deficiency Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF) Progesterone Therapy and Preterm Birth: More Evidence Helps Identify Women Who Can Benefit Pulmonary Fibrosis Mortality Rates Continue to Increase, Especially in Women Generex Biotechnology to Exhibit At American Association of Diabetes Educators Annual Meeting & Exhibition Oxford Biomedica: Publication of Trovax Phase II Clinical Trial Data Side Effects of New Drug for High-Risk Breast Cancer Are Manageable Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors

August 7

Arpida Presents a Large Body of Preclinical and Clinical Data at Scientific Conferences Deflux Significantly Reduces Urinary Tract Infections in Children With Vesicoureteral Reflux EPIX Pharmaceuticals Announces Positive Results from Phase 2a Clinical Trial of First-in-Class 5-HT2B Antagonist in Patients with Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease Hydra Biosciences Announces Data Revealing the Crucial Role Played by the TRPA1 Ion Channel in a Standard Model of Pain Receptor Activation JCEM Publishes Data from OXiGENE-sponsored Preclinical Study of Combretastatin A4 phosphate / CA4P Triple-Drug Combinations in Anaplastic Thyroid Cancer Researchers at Cleveland Clinic Identify Site of 'Dysfunction' in HDL, Carrier of Good Cholesterol Gene Predicts Better Outcome as Cortex Normalizes in Teens with ADHD Peregrine's Bavituximab HCV Phase Ib Study Results Selected for Oral Presentation at Upcoming AASLD Annual Meeting

August 20

Intellect Neurosciences, Inc. to Present Data on Alzheimer's Vaccine at 13th International Congress of Immunology Conference PNH Patients Treated with Soliris Experienced Dramatic Reduction in Blood Clots During Clinical Trials Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge) in Advanced Breast Cancer Patients Adnexus Therapeutics to Present Data on Adnectin Product Candidate, CT-322, at Gordon Research Conference Tysabri Demonstrates Significant Health-Related Quality-of-Life Improvements for Multiple Sclerosis Patients in Study Published in Annals of Neurology Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab, in Non-Human Primates Metabasis Therapeutics Presents Preclinical Results Demonstrating Potential Advantages of MB07811 as a Treatment for Hyperlipidemia Can-Fite Successfully Completes Preclinical Trials With Its Second Drug Candidate CF102 Intercell’s Therapeutic Hepatitis C Vaccine Meets Primary Endpoints in Phase II Interim Analysis

August 23

ProNAi Therapeutics Announces First DNAi Mechanism of Action Studies for PNT2258 Oncology Drug Candidate Poniard Pharmaceuticals to Present Updated Results of Picoplatin Phase 2 Small Cell Lung Cancer Trial at 12th World Conference on Lung Cancer Encouraging Phase II Data on HIV Vaccine Utilizing GenVec Technologies Presented at Seattle AIDS Conference Iomai Announces Data from Phase 2 Field Study of Travelers' Diarrhea Vaccine Accepted for Presentation at ICAAC CollaGenex Pharmaceuticals Announces Highly Positive Results of Phase 2 Dose-Finding Trial of Col-118 for the Treatment of Erythema Opexa to Present Proprietary T-Cell Technology at Vaccine Conference on August 24, 2007 ReGen Therapeutics Plc - Research Update Multiple NIH Phase 2 HIV Vaccine Trials Using Vical's Technology Produce Encouraging Results ZymoGenetics Will Hold Conference Call Today at 5:00 p.m. Eastern Time to Provide Update on rThrombin Paper in Advances in Experimental Medicine and Biology Reports Alfacell's Onconase Enhances Effect of Radiation in Non-Small Cell Lung Cancer MedImmune's Motavizumab Reduced RSV Hospitalizations by 83 Percent Among High-Risk Native American, Full-Term Infants in Placebo-Controlled Phase 3 study

August 27

Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial Ascenta Therapeutics Presents New Clinical Data on AT-101 for the Treatment of Hormone-Refractory Prostate Cancer New Data Highlights Long Term Tolerability and Sustained Benefits of the Exelon Patch in the Treatment of Alzheimer’s Disease New Study May Explain Vioxx Side-effects Adnexus Therapeutics Announces Additional Phase I and Preclinical Data on CT-322 at 6th International Congress on Targeted Therapies in Cancer Actelion to Discuss Results from the Early, Compass-1, Future and Benefit Studies Presented at the European Society of Cardiology Congress Actelion to announce results from 'proof-of-concept'/dose ranging study of its novel orexin receptor antagonist during the 2007 World Sleep Congress Is it Safe to Use Oral Contraceptives to Eliminate Periods? Harvard Women's Health Watch Explores the Question Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation ImmuneRegen BioSciences, Inc. Demonstrates Radilex Increases Disease-Fighting White Blood Cells Geron Scientists and Collaborators Demonstrate Human Embryonic Stem Cell-Derived Cardiomyocytes Improve Heart Function When Transplanted After Myocardial Infarction NIH Scientists Discover Novel Cause of Iron Overload in Thalassemia Disorders

August 28

Antares Pharma Will Present Anturol at the 28th Annual Scientific Meeting of the American Urogynecologic Society Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 Evotec to Present Details of the Positive Phase II Study in Insomnia With EVT 201 at the Worldsleep07 Congress in Cairns/Australia New Kaiser Permanente Study Shows Treating Diabetes During Pregnancy Can Break Link to Childhood Obesity Allergy Patients Treated with PreHistin Had Rise in Ragweed IgE Antibodies Blunted During Pollen Season Prodest Study Shows Many Parkinson’s Disease Patients Continue to Experience PD-Related Depressive Symptoms Despite Receiving Anti-Depressant Treatment Journal of American College of Cardiology Publishes Positive Findings on Generx Now in Phase 3 for Heart Disease

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