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Welichem Succesfully Completes Phase I Clinical Trial

BURNABY, BC, July 8, 2008 /CNW/ - Welichem Biotech Inc. (the "Company") (TSX-V:  WBI) is pleased to announce the successful completion of and the results from  a randomized, double-blinded Phase I clinical trial done in Montreal Canada,  which evaluated topically applied WBI-1001 in 36 psoriasis patients.      

The Phase I study succeeded in meeting both its primary and secondary  objectives. The primary objectives were to evaluate the safety and  tolerability and to assess the pharmacokinetics of topically applied WBI-1001.  The secondary objective was to obtain an initial evaluation of the efficacy of  the WBI-1001 cream. The trial was conducted through six separate treatment  groups, each consisting of six patients with mild-to-moderate psoriasis. All  patients within a given treatment group received the same dosage of WBI-1001  on one side of the body and a placebo on the other side. Each treatment group  received a unique dosage (0.5%, 1.0% or 2.0%) of WBI-1001 on the affected  areas either once or twice a day.      

WBI-1001 demonstrated an excellent non-cutaneous safety profile. The 0.5%  and 1.0% doses of WBI-1001 exhibited very good skin tolerance in this study.  Some patients that were treated with the 2.0% WBI-1001 cream experienced mild  skin related adverse events which are common to established topical therapies  for psoriasis. There were no serious adverse events in the study. The results  of the pharmacokinetic study showed extremely low concentration of WBI-1001 in  the blood. There was no evidence that WBI-1001 accumulated systemically upon  once or twice daily application over a period of 28 days.      

Several criteria were used to assess efficacy: physician's global  assessment (PGA), induration, erythema, scaling and body surface area (BSA).  Overall, data from the study suggest that WBI-1001 cream is efficacious on  psoriasis as demonstrated by greater improvement in PGA, induration, erythema,  and scaling when compared with the placebo cream. After 28 days of treatment  with WBI-1001, the mean scores for PGA, induration, erythema and scaling for  all subjects were reduced from that of the baseline appreciably more for the  WBI-1001-treated side than for the placebo-treated side. Improvement in the  mean scores for PGAs, induration, erythema and scaling started around Day 14,  and was maintained or further increased up to Day 35 (7 days post-dose) in the  majority of the treatment groups. The short-term nature of the study did not  allow treatment differences to emerge between treatment groups in the BSA  criterion.      

A Phase II study to confirm and further explore WBI-1001 as a topical  cream application against mild to moderate psoriasis is planned for 2009.   

About psoriasis   

Psoriasis is a chronic, autoimmune skin disease characterized by uneven,  scaly and often inflamed and itchy patches. It affects some 1-3% of the  world's population and is largely under-diagnosed and under-treated. There is  no cure for psoriasis, and patients have to switch therapies frequently over a  long period to determine an optimum treatment regime due to drug intolerance,  adverse side effects or lack of efficacy of the drugs currently in the market.  The psoriasis market had global sales of $1.95 billion in 2005. WBI-1001  targets the market for patients with mild-to-moderate psoriasis, which  accounts for 80% of persons with this disease. It diminishes inflammation and  plaque rapidly and targets the cause of the disease through selective  inhibition of pro-inflammatory cytokines and key pathogenic cells.   

About Welichem Biotech Inc.   

Welichem Biotech Inc. is a publicly-traded biotechnology company  developing therapeutic drugs in the fields of autoimmune, inflammatory  diseases and cancer.   

ON BEHALF OF THE BOARD       Genhui Chen, Ph.D.       President and CEO   

The TSX Venture Exchange has not reviewed and does not accept  responsibility for the adequacy or accuracy of the content of this news  release. This press release contains forward-looking statements that include  our belief as to the potential of our products. Certain risks and  uncertainties such as our ability to successfully commercialize the products  could cause the Company's actual results to differ materially from those in  the forward-looking statements. The Company thus seeks safe harbour.   

For further information: Genhui Chen, Tel.: (604) 432-1703, Email:  gchen@welichem.com; Yan Chen, Business Development Manager, Tel.: (604)  432-1703, Email: investors@welichem.com

   

Posted: July 2008

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