Symphogen Publishes Pre-Clinical Data in Cancer Research Demonstrating Superior Efficacy of Anti?EGFR Monoclonal Antibody Combination Sym004
Novel mechanism of action resulted in superior anticancer effects vs ERBITUX® and Vectibix®
Sym004 advancing into the clinic
Results further validate Symphogen's proprietary discovery platforms to identify potential antibody therapeutics for serious diseases
COPENHAGEN & PRINCETON, N.J.--(BUSINESS WIRE)--Jan 11, 2010 - Symphogen A/S today announced the publication of encouraging data for Sym004 in the on-line edition of Cancer Research (January 15, 2010; 70(2)). The data showed that Sym004 provided synergistic inhibitory effects against cancer cell lines of different tissue origin in vitro and in vivo.
Sym004 is a therapeutic composed of two anti-epidermal growth factor receptor (EGFR) monoclonal antibodies against different nonoverlapping EGFR epitopes. Like other anti-EGFR antibodies, Sym004 inhibits cancer cells by blocking ligand binding, receptor activation/phosphorylation, and downstream signaling. However, Sym004 also showed a unique ability to induce rapid and efficient removal of the EGFR receptors from the cancer cell surface by inducing EGFR internalization and degradation.
“We believe that Sym004's novel mechanism of action resulted in these impressive results demonstrating antitumor activity in EGFR-expressing tumors and that the combination of these two antibodies to form Sym004 led to the powerful synergistic effects demonstrated in this study,” stated Kirsten Drejer, M.Sc. and Ph.D., Chief Executive Officer of Symphogen. “We are hopeful that Sym004 proves to be a safe and efficacious agent for patients and we look forward to advancing Sym004 into Phase 1 clinical trials soon.”
“Even with the two approved anti-EGFR antibody therapies on the market, cetuximab and panitumumab, there remains a strong unmet need for more efficacious treatments for patients with EGFR-resistant tumors,” stated Josep Tabernero, M.D., Head of Gastrointestinal Tumors and Phase I Unit at Vall d'Hebron University Hospital in Barcelona, Spain. “The preclinical results indicate that Sym004 appears to exhibit anti-cancer effects on EGFR-resistant tumors. We look forward to reviewing ongoing clinical data from Sym004 as the compound progresses through development.”
Data Reported in Cancer Research
“Sym004 specifically targets EGFR on cancer cells, which is a proven and attractive therapeutic target and represents a potential multi-billion dollar market opportunity,” continued Dr. Drejer. “This data validates the ability of our proprietary antibody discovery and screening platforms to identify and select potent monoclonal antibody combinations that more effectively address the multi-mechanistic nature of cancer. We believe our approach should translate to other ligand-dependent cancers as well as other serious diseases with complex target antigens, including many autoimmune and infectious diseases.”
Symphogen is developing superior antibody therapeutics (monoclonal, biclonal and polyclonal) to help people with serious diseases and significant unmet medical needs. With its proprietary, unique Symplex™ discovery and Sympress™ manufacturing platforms, the company captures the diversity and specificity of the natural immune response in rationally designed recombinant antibody compositions. Symphogen is maturing a diversified pipeline of internal and partnered products across multiple indications including cancer, autoimmune and infectious disease. Symphogen is a private biopharmaceutical company headquartered in Copenhagen, Denmark, with a US subsidiary in Princeton, New Jersey.
Contact: Symphogen A/S
Chief Executive Officer
+45-6118-7494 or +45-2210-9959
Adriann Sax, +1-908-794-1085
Chief Business Officer
For Symphogen, Inc.
Kathryn Morris (media)
Posted: January 2010