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Stealth Peptides' Bendavia Introduced During Experimental Biology 2011 Meeting

BOSTON--(BUSINESS WIRE)--Apr 20, 2011 - Stealth Peptides Inc. (Stealth), a privately held biopharmaceutical company developing innovative mitochondrial therapies, introduced its lead clinical candidate, Bendavia™, a novel compound that targets the mitochondrion, during multiple scientific sessions of the Experimental Biology 2011 meeting. Experimental Biology is an annual meeting with an estimated 15,000 attendees across several fields of study that include biochemistry, molecular biology, nutrition, pharmacology and immunology. The 2011 meeting was held from April 9th through 13th in the Walter E. Washington Convention Center, Washington D.C.

During a Mitochondrial Function and Disease Symposium from the meeting's Biochemistry Sessions, Dr. Hazel Szeto of Cornell University, Stealth's founder, presented an overview of Bendavia and its potential for treating cardio–renal diseases and critical care conditions including severe burn and muscle trauma. Dr. Peter Rabinovitch, University of Washington, also presented an overview of Bendavia and its potential for treating age related disorders and heart failure during a Systems Biology of Oxidative Stress and Therapeutic Implications Symposium from the meeting's Pharmacology Sessions.

The initial clinical program for Bendavia is the treatment of ischemia reperfusion injury, a common complication of interventional procedures for acute myocardial infarction (AMI) and coronary bypass surgery. Standard animal models for AMI demonstrate Bendavia's beneficial myocardial effects and confirm the significance of its novel mechanism of action, which preserves mitochondrial function under pathological conditions, for ischemia reperfusion injury.

Contrary to prior therapeutic strategies for ischemia reperfusion injury and AMI that focused on uni–targeted pathways, Bendavia and its mitochondrial directed actions address the more complicated, multifactorial nature of diseases. Specifically, Bendavia has been shown to improve electron transport efficiency, maintain mitochondrial respiration and adenosine triphosphate levels and prevent mitochondrial swelling and depolarization. Bendavia also appears to be a strong neurologic protectant, which holds promise as a treatment for cardiac arrest and stroke patients.

Stealth's CEO, Travis Wilson, remarked “Stealth is enthusiastic about the reception of Bendavia and its preclinical data following the symposiums for both Drs. Szeto and Rabinovitch. Based on the successful conclusion of our Phase I clinical trials and encouraging pharmacology data such as that presented during this year's Experimental Biology meeting, we feel that Bendavia has the potential to be a paradigm shifting therapy for mitochondrial dysfunction, which underlies many common diseases including cardio–renal, age and metabolic related disorders.”

Stealth is currently initiating a multinational Phase II clinical study with Bendavia focused on ischemia reperfusion injury for patients experiencing acute ST–segment elevation myocardial infarction (STEMI). Stealth's Phase II clinical trial is termed EMBRACE–STEMI™ for the Evaluation of the Myocardial effects of Bendavia for reducing Reperfusion injury in patients with Acute Coronary Events.

More information regarding Stealth and its development programs for Bendavia is available at www.stealthpeptides.com.

About Acute Myocardial Infarction

Statistics from the AHA indicate that more than 600,000 people within the U.S. die from heart disease and AMI each year, an amount greater than the combined total of mortalities from every type of cancer. As background, ischemia is defined as the inadequate supply of oxygen and nutrients to maintain normal cellular aerobic metabolism. It arises primarily from a lack of blood flow to tissue and is seen in a variety of clinical conditions including stroke, AMI, acute and chronic kidney injury and organ transplantation. In tissues with high metabolic activity, such as the brain and heart, adenosine triphosphate stores are depleted within the first few minutes of ischemia. Standard–of–care reperfusion therapies for AMI include primary percutaneous coronary intervention and thrombolysis. Prompt restoration of blood flow to the ischemic myocardium limits infarct size, which is a major determinant of mortality and morbidity for AMI patients. Paradoxically, the return of blood flow after ischemia can also result in additional cardiac damage and complications. This phenomenon known as reperfusion injury is associated with an array of myocardial, vascular and electrophysiological derangements that can increase infarct size and cause long–term clinical deterioration and complications including heart failure. To date, effective therapies to reduce or prevent reperfusion injury have proven elusive. Through its mitochondrial directed actions, Bendavia appears to be a lead candidate for innovative pharmacologic approaches to reduce ischemia reperfusion injury in patients.

About Stealth Peptides

Stealth has a rich and promising pipeline of preclinical and clinical compounds from a unique class of short peptides (500–700 Daltons each) that target mitochondria. Published, peer–reviewed data for these compounds suggest significant in vitro and in vivo efficacy for metabolic, ophthalmologic, neurologic and cardio–renal related disorders. The intellectual property portfolio around these compounds is exceptionally robust with compositions, including Bendavia, protectable by patent until 2031.

More information regarding Stealth and its pipeline is available at www.stealthpeptides.com.

 

Contact: Stealth Peptides Inc.
Travis Wilson, 617-244–2800
CEO
Travis.Wilson@stealthpeptides.com

 

Posted: April 2011

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