Silence's Atu027 Prevents Cancer Spread to Lungs - Peer Review Paper Published

Positive Findings from Atu027 Study Published in Clinical Cancer Journal

London, November 10, 2010 – Silence Therapeutics plc (AIM: SLN) (“Silence” or the “Company”) announces positive research findings demonstrating the ability of the Company’s lead RNA interference (RNAi) drug candidate, Atu027, to prevent the formation of pulmonary metastasis in various animal models of cancer metastasis. Researchers showed that Atu027 inhibited multiple key biological processes that enable and contribute to the dissemination and formation of pulmonary metastases in a murine breast cancer metastasis model. It is important to note that breast cancer cells prefer to metastasize through the bloodstream to the lung. The findings were published in the latest edition of the scientific journal Clinical Cancer Research in a peer-reviewed paper entitled; “Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models.”


Atu027 is a proven inhibitor of the expression of PKN3, a molecule that is believed to play an important role in the progression of cancer and metastasis formation in particular. In the study, researchers administered Atu027 to multiple mouse models of breast cancer to evaluate the drug’s ability to prevent the spread of the cancer to the lungs. Study data demonstrated that Atu027 has a clear inhibitory effect on the formation of pulmonary metastasis. With metastasis directly linked to high rates of mortality in cancer patients, the prevention of metastasis dissemination and formation is a critical goal of cancer treatment.


“While the demonstrated inhibition of pulmonary metastasis formation was a positive and important outcome of this study, equally important is what we learned regarding the manner in which Atu027 is able to achieve this effect. These findings showed that in addition to our previously published research demonstrating its ability to inhibit metastasis through the lymphatic system, Atu027 also appears to interrupt the metastatic processes that involve blood flow to the lung,” stated Klaus Giese, Ph.D., chief scientific officer at Silence Therapeutics. “Importantly, these data provide us with evidence that Atu027, which targets vascular endothelial cells, may be modulating not only the tumor vasculature itself, but the pulmonary vasculature as well.”


“We are very pleased to be able to continue to identify the mechanisms that drive Atu027’s therapeutic activity while concurrently advancing the product through its ongoing Phase 1 study. Building this collection of novel data on Atu027 will only serve to inform our ongoing development efforts and allow us to maximize the opportunity for success with this program,” said Philip Haworth, Ph.D., chief executive officer of Silence Therapeutics.

Atu027, a liposomal AtuRNAi™ formulation in clinical development for systemic cancer indications, is one of the most clinically advanced RNAi therapeutics in the area of oncology. In June 2009, Silence initiated an open-label, single-centre, dose-escalation Phase I study with Atu027 in patients with advanced solid (malignant) tumors involving single, as well as, repeated intravenous administration. The study is expected to be completed early in the second half of 2011.


About Silence Therapeutics plc (www.silence-therapeutics.com)

Silence Therapeutics plc (AIM: SLN) is a leading global biotechnology company dedicated to the discovery, development and delivery of targeted, systemic RNA interference (RNAi) therapeutics for the treatment of serious diseases. The company possesses multiple proprietary short interfering RNA (siRNA) delivery technology platforms including AtuPLEX™, a system that enables the functional delivery of siRNA molecules to targeted diseased tissues and cells, while increasing their bioavailability and intracellular uptake. A second, complementary delivery technology known as PolyTran™ uses a library of novel peptide-based biodegradable polycationic polymers for systemic siRNA administration. Additionally, the company has a platform of novel siRNA molecules, AtuRNAi, which provide a number of advantages over conventional siRNA molecules, including increased stability against nuclease degradation. Silence’s unique RNAi assets also include structural features for a next generation of RNAi molecules and additional proprietary siRNA sequences against more than 50 highly valued oncology and other disease targets.

The company’s strong and diverse intellectual property portfolio includes exclusive licenses from the University of Massachusetts Medical School on three patent families associated with the “Zamore Design Rules,” which cover broad structural features of siRNA design for more potent next generation siRNA sequences.


Silence Therapeutics is headquartered in London, UK, with research and development activities in Berlin and operations in Redwood City, CA.


Forward-Looking Statements

This press release includes forward-looking statements that are subject to risks, uncertainties and other factors. These risks and uncertainties could cause actual results to differ materially from those referred to in the forward-looking statements. All forward-looking statements are based on information currently available to Silence Therapeutics and Silence Therapeutics assumes no obligation to update any such forward-looking statements.

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Posted: November 2010

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