Researchers Restore Neuron Function to Brains Damaged by Huntington's Disease
Use of transplanted induced pluripotent stem cells could lead to new treatments for HD
Grand Rapids, Mich. (May 29, 2012) – Researchers from South Korea, Sweden, and the United States have collaborated on a project to restore neuron function to parts of the brain damaged by Huntington’s disease (HD) by successfully transplanting HD-induced pluripotent stem cells into animal models.
Induced pluripotent stem cells (iPSCs) can be genetically engineered from human somatic cells such as skin, and can be used to model numerous human diseases. They may also serve as sources of transplantable cells that can be used in novel cell therapies. In the latter case, the patient provides a sample of his or her own skin to the laboratory.
In the current study, experimental animals with damage to a deep brain structure called the striatum (an experimental model of HD) exhibited significant behavioral recovery after receiving transplanted iPS cells. The researchers hope that this approach eventually could be tested in patients for the treatment of HD.
“The unique features of the iPSC approach means that the transplanted cells will be genetically identical to the patient and therefore no medications that dampen the immune system to prevent graft rejection will be needed,” said Jihwan Song, D.Phil. Associate Professor and Director of Laboratory of Developmental & Stem Cell Biology at CHA Stem Cell Institute, CHA University, Seoul, South Korea and co-author of the study.
The study, published online this week in Stem Cells, found that transplanted iPSCs initially formed neurons producing GABA, the chief inhibitory neurotransmitter in the mammalian central nervous system, which plays a critical role in regulating neuronal excitability and acts at inhibitory synapses in the brain. GABAergic neurons, located in the striatum, are the cell type most susceptible to degeneration in HD.
Another key point in the study involves the new disease models for HD presented by this method, allowing researchers to study the underlying disease process in detail. Being able to control disease development from such an early stage, using iPS cells, may provide important clues about the very start of disease development in HD. An animal model that closely imitates the real conditions of HD also opens up new and improved opportunities for drug screening.
“Having created a model that mimics HD progression from the initial stages of the disease provides us with a unique experimental platform to study Huntington's disease pathology” said Patrik Brundin, M.D., Ph.D., Director of the Center for Neurodegenerative Science at Van Andel Research Institute (VARI), Head of the Neuronal Survival Unit at Lund University, Sweden, and co-author of the study.
Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems. It typically becomes noticeable in mid-adult life, with symptoms beginning between 35 and 44 years of age. Life expectancy following onset of visual symptoms is about 20 years. The worldwide prevalence of HD is 5-10 cases per 100,000 persons. Key to the disease process is the formation of specific protein aggregates (essentially abnormal clumps) inside some neurons.
Link to the study abstract: “Neuronal Properties, In Vivo
Effects and Pathology of a Huntington’s Disease
Patient-Derived Induced Pluripotent Stem Cells”
CHA Stem Cell Institute
Founded by Dr Kwang Yul Cha in 2000, CHA Stem Cell Institute in CHA University is dedicated to understanding of basic mechanisms underlying pluripotency, cell fate control and differentiation of stem cells, as well as translational research for clinical application of basic study to treat currently incurable diseases, including Huntington’s disease, myocardial infarct, and diabetes. Our aim is to provide scientific and clinical evidence for therapeutic application of stem cells. http://en.cha.ac.kr
Neuronal Survival Unit
The research at Neuronal Survival Unit, Lund University, Sweden is focused on pathogenetic mechanisms and pharmacological treatment in cell and animal models of Parkinson’s and Alzheimer’s diseases. We also study cell replacement therapy with stem cells in attempts to repair brains in animal models of Parkinson’s diseases. The group’s mission is to understand neurodegenerative diseases and develop new therapies that are of benefit to patients and their caregivers. http://www.med.lu.se/expmed/neuronal_survival_unit
Van Andel Institute
Established by Jay and Betty Van Andel in 1996, Van Andel
Institute is an independent research organization dedicated to
preserving, enhancing and expanding the frontiers of medical
science, and to achieving excellence in education by probing
fundamental issues of education and the learning process. This is
accomplished through the work of over 200 researchers in more than
20 on-site laboratories and in collaborative partnerships that span
Posted: May 2012