Published in "Bone" Journal, Scientific Researches Confirm Peptan Hydrolyzed Collagen Benefits on Bone Health
- Studies Conducted at INRA-Agroparistech Laboratory Under Pr.
Daniel Tome's Supervision and Published* in November 2009, in the
Official Journal of the International Bone and Mineral Society
"Bone", Reveal new Benefits for Peptan(TM) in Osteoporosis
PUTEAUX, France, December 16/PRNewswire/ -- In
response to consumer concerns regarding long-term bone health,
Rousselot has carried out, for several years now, many studies to
demonstrate that an oral intake of Peptan(TM) may have a positive
impact on osteoporosis.
Bone is a living dynamic metabolic system that relies on a
maintained balance between bone formation and bone resorption.
Cells called osteoblasts make bone while cells called osteoclasts
resorb it. An imbalance may lead to osteoporosis, a condition where
the density and quality of bone is reduced.
Researchers conducted in vitro studies, and highlighted that
Peptan(TM) in bone cell culture induced a better differentiation of
osteoblasts. Those positive results have then been confirmed in
vivo on ovariectomized mice, used to simulate a postmenopausal
osteoporosis, which leads to a lower bone mineral density
Animals were divided into three groups: a control group (non
ovariectomized), a group of ovariectomized mice, both fed with a
normal diet and a group of ovariectomized mice that received a diet
containing Peptan(TM). After 12 weeks, the BMD of the group fed
with Peptan(TM) is not significantly different from the BMD of
control group. On the contrary the BMD of ovariectomized mice not
fed with Peptan(TM) is lower.
Confirmation of Peptan(TM) benefits on bone health has been
obtained by the measures of Carboxy Terminal Telopeptide (CTX), a
usual marker of bone resorption. CTX is significantly lower in mice
fed with Peptan(TM) indicating that bone resorption is
Researchers conclude that Peptan(TM) may restore bone density in
simulated post-menopausal osteoporosis by stimulating osteoblast
growth and differentiation. This demonstrates the interest of
Peptan(TM) as a bioactive ingredient to help preventing bone loss
*Hydrolyzed collagen improves bone metabolism and biomechanical
parameters in ovariectomized mice: an in vitro and in vivo study.
Guillerminet et al. Bone 2009.
Part of VION N.V. (N.L.), Rousselot(R) is the worldwide leader
in gelatine and hydrolyzed collagen. VION N.V. is an
internationally operating food group that produces high-quality
foods and ingredients for humans and animals (Turnover: EUR 9.6
billion - 31,000 employees worldwide)
Source: ROUSSELOT SAS
Caroline Brochard-Garnier, Communication, +33-1-46-67-87-27, email@example.com
Posted: December 2009