Promising Results in Treating Facial Bruising From Injectables

Top physician leading clinical trials

FREEPORT, N.Y., September 26, 2007 /PRNewswire/ -- Physicians nationwide report promising results in treating facial bruising from injectable cosmetic treatments by using Pinoxide(TM), an active ingredient best known for treating under-eye circles.

Pinoxide is a proprietary blend of bicyclic monoterpene dials (BMTd) created by AGI Dermatics and formulated in the company's Remergent Microcirculation Therapy product. Pinoxide has been clinically proven to speed blood flow, warm the skin, increase resistance to cold, and reduce dark under- eye symptoms. Additional research suggests Pinoxide may also contribute to promoting firmness and resiliency in the skin. Now, physicians are studying the ingredient's ability to heal bruising.

Dr. Mark G. Rubin, a board-certified dermatologist currently practicing at the Lasky Clinic in Beverly Hills, is conducting the clinical trials on Pinoxide, applying the Microcirculation Therapy formula to the injection site immediately after use of skin fillers such as collagen, Restylane and Juvederm, or Botox.

"Anatomically speaking, dark circles are like bruises - so the science behind using Pinoxide for bruising makes total sense," said Dr. Rubin. "The skin discoloration during bruising is the result of blood leaking from damaged blood vessels and surfacing to the skin. Similarly, blood vessels under the eyes can burst, leading to the appearance of unattractive dark circles."

Leading dermatologists share Dr. Rubin's opinion. Dr. Thomas Francel, a board certified plastic surgeon, has found that application of MicroCirculation Therapy on his patients reduces the appearance of skin bruising, and decreases the amount of healing time for the bruise. Dr. Francel is the Chief of Plastic Surgery at St. John's Mercy Medical Center and an Associate Professor of Surgery at St. Louis University.

Injectable cosmetic treatments are among the five top most requested aesthetic treatments nationwide last year. According to the American Society for Aesthetic Plastic Surgery, more than 5 million women had injectable cosmetic treatments last year. Bruising is a common temporary side effect.

AGI Dermatics is the bio-pharmaceutical laboratory that has led the research of DNA repair of the skin for more than 20 years. Founded by Daniel B. Yarosh, PhD, AGI Dermatics specializes in skin photobiology, dedicating research and development to DNA repair, solar impact on the immune system, and cell-signaling in skin. The company's application of groundbreaking active ingredients and meticulously engineered liposome delivery systems is validated in controlled clinical studies and published in dozens of peer-reviewed scientific and medical journals.

CONTACT: Liz Mefford, , or Courtney McGeever,, both of Rpr Marketing Communications,+1-212-317- 1462 Liz.mefford@rprny.com Courtney.mcgeever@rprny.com

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Posted: September 2007

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