PolyMedix Presents Antimicrobial Compound Data at Two Prestigious Scientific Meetings
RADNOR, Pa.--(BUSINESS WIRE)--May 25, 2011 - PolyMedix, Inc. (OTC BB: PYMX), an emerging biotechnology company focused on developing new therapeutic drugs to treat life-threatening infectious diseases and acute cardiovascular disorders, announced today that new pre-clinical data for its novel, defensin-mimetic antimicrobial compounds was recently presented at two prestigious scientific meetings, including the American Society of Microbiology. The data presented showed activity against oral mucositis and a broad array of pathogens, including malaria, candida, anthrax and foodborne pathogens. The presentations are available on PolyMedix's website at www.Polymedix.com.
“These data continue to support the breadth and potential of our defensin-mimetic antimicrobial compounds in addressing serious infectious diseases that cause severe human and public health issues,” commented Dr. Richard Scott, Vice President of Research at PolyMedix. “The importance of our research is reflected in the high degree of attention it receives from the scientific community. We remain committed to continuing research to further advance these programs and expanding their scope.”
PolyMedix presented the following pre-clinical data in poster form at the Annual Society of Microbiology meeting in Louisiana on May 24 and 25:
- Small Nonpeptidic Mimics of Host
Defense Proteins as Potential Antimalarial Drugs
Under a grant received from the National Institute of Health (NIH), PolyMedix tested hundreds of its antimicrobial compounds and identified several new compounds that kill the malaria parasite, Plasmodium falciparum. These compounds show low cytotoxicity and do not harm human cells, as well as have the possibility for oral activity.
- Identification of Novel Host Defense
Protein Mimics for Treatment of Oral Candidiasis
Under a grant that PolyMedix received from National Institute of Health (NIH) to support the development of defensin-mimetic antimicrobial compounds for the treatment of oral candidiasis (a fungal infection), PolyMedix has identified several compounds that show cidal activity against Candida albicans. The compounds tested show varied selectivity profiles against human cells and bacteria, indicating that compounds can be identified that are active specifically against bacteria or fungi but do not harm human cells. In addition, the antimicrobial activity of the lead compounds was unaffected by saliva.
- Nonpeptidic Mimics of Host Defense
Proteins as Antimicrobial Agents for Foodborne Pathogens
PolyMedix continues to test its antimicrobial compounds against the most prevalent foodborne pathogens. The data presented showed that 30 of PolyMedix's compounds are broadly active against at least 6 of the 8 foodborne pathogens tested. In addition, PolyMedix identified 14 highly selective compounds that have antimicrobial activity against Campylobacter jejuni, the leading cause of bacterial foodborne gastroenteritis. The results showed no evidence for the emergence of resistance in serial passage assays with Salmonella enterica versus the PolyMedix compounds.
At a second research conference focused on providing an international forum for the presentation and confidential discussion of frontier research in the biological, chemical, and physical sciences, Dr. Scott presented data on May 18th pertaining to the multiple therapeutic applications for PolyMedix's antimicrobial compounds. PolyMedix has identified compounds with activity in pre-clinical studies against Candida fungal organisms, which cause severe yeast infections of the mouth, and in animal models of anthrax and oral mucositis.
At the same conference, Dr. Doron Greenbaum, Assistant Professor of Pharmacology at the University of Pennsylvania, presented in vitro data showing that PolyMedix's antimicrobial compounds, with their unique mechanism of action, show promising activity as potential therapeutic agents for malaria. The data presented showed that PolyMedix's antimicrobial compounds potently killed the parasite that causes malaria in infected human red blood cells without damaging uninfected red blood cells.
The research described above was funded by the NIH, is solely the responsibility of the authors and does not necessarily represent the official view of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health.
About PolyMedix, Inc.
PolyMedix is a publicly traded biotechnology company focused on the development of novel drugs for the treatment of serious infectious diseases and acute cardiovascular disorders. PolyMedix uses a rational drug design approach to create non-peptide, small-molecule drug candidates. PolyMedix's lead antibiotic compound, PMX-30063, is currently in a Phase 2 clinical trial for treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI) caused by Staph, including MRSA. PMX-30063 is a small-molecule that mimics the mechanism of action of human host defense proteins, a mechanism that is distinct from currently approved antibiotic drugs and is intended to make bacterial resistance unlikely to develop. PolyMedix's lead heptagonist compound, PMX-60056, is in a Phase 2 clinical trial in patients undergoing PCI procedures. PMX-60056 is designed to reverse the anticoagulant activity of both heparin and low molecular weight heparins (LMWH). PolyMedix believes that PMX-60056 could potentially be a safer and easier to use anticoagulant reversing agent, with broader activity, than the currently approved therapy for reversing heparin and LMWH. In addition to its small molecule therapeutics, PolyMedix has polymeric formulations with the same mechanism of action as PMX-30063, PolyCides®. PolyCides are intended for use in antimicrobial biomaterials applications as additives to paints, plastics, and textiles to create self-sterilizing products and surfaces. For more information, please visit our website at www.polymedix.com.
This press release contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 that involve risks, uncertainties and assumptions that could cause PolyMedix's actual results and experience to differ materially from anticipated results and expectations expressed in these forward looking statements. PolyMedix has in some cases identified forward-looking statements by using words such as “anticipates,” “believes,” “hopes,” “estimates,” “looks,” “expects,” “plans,” “intends,” “goal,” “potential,” “may,” “suggest,” and similar expressions. Among other factors that could cause actual results to differ materially from those expressed in forward-looking statements are PolyMedix's need for, and the availability of, substantial capital in the future to fund its operations and research and development, and the fact that PolyMedix's compounds may not successfully complete pre-clinical or clinical testing, or be granted regulatory approval to be sold and marketed in the United States or elsewhere. A more complete description of these risk factors is included in PolyMedix's filings with the Securities and Exchange Commission. You should not place undue reliance on any forward-looking statements. PolyMedix undertakes no obligation to release publicly the results of any revisions to any such forward-looking statements that may be made to reflect events or circumstances after the date of this press release or to reflect the occurrence of unanticipated events, except as required by applicable law or regulation.
Contact: PolyMedix, Inc.
Director, Investor Relations & Corporate Communications
Posted: May 2011