Pharmacyclics Announces Presentations and Published Abstracts on Xcytrin at The 2007 American Society of Clinical Oncology Annual Meeting

SUNNYVALE, Calif., May 23, 2007 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. announced today multiple presentations and a published abstract regarding Xcytrin(R) (motexafin gadolinium) Injection, including an oral presentation of Phase 3 SMART (Study of Neurologic Progression with Motexafin Gadolinium And Radiation Therapy) trial data. The presentations and publications are part of the proceedings at the 2007 American Society of Clinical Oncology Annual Meeting (ASCO) that will be held June 1-5, 2007, at McCormick Place in Chicago, IL.

    The presentations and published abstracts are as follows:


    Sunday, June 3, 2007

    Session: Central Nervous System Tumors

    Oral Presentation: Motexafin gadolinium (MGd) combined with whole brain

    radiation therapy prolongs time to neurologic progression in non-small

    cell lung cancer (NSCLC) patients with brain metastases: Pooled analysis

    of two randomized phase III trials. Abstract #2010: 3:00 - 3:15 p.m.


    Location: S100a

    Presenter: William Shapiro, M.D., Barrow Neurological Institute,

    Phoenix,AZ


    Session: Central Nervous System Tumors


    Poster Presentation: Identification of occult brain metastases amenable to

    stereotactic radiosurgery by motexafin gadolinium (MGd) based treatment

    planning MRI: Results of a phase II trial of MGd and whole brain

    radiotherapy (WBRT) with stereotactic radiosurgery (SRS).

    Abstract #2037: 8:00 a.m. - 12:00 p.m.;

    Discussion: 11:00 a.m. - 12:00 p.m.


    Poster Display Location: S102a; Discussion: S100a

    Presenter: Minesh P. Mehta, M.D., University of Wisconsin


    Motexafin Gadolinium Published Abstract

    Abstract #18001

    Title: A phase II trial of motexafin gadolinium (MGd) in advanced

    non-small-cell lung cancer (NSCLC) patients who had failed platinum-based

    chemotherapy: Preliminary results of Stage 1

About Xcytrin

Pharmacyclics is developing Xcytrin as an anti-cancer agent with a novel mechanism of action that is designed to selectively concentrate in tumors and induce apoptosis (programmed cell death). Xcytrin is a redox-active drug that has been shown to disrupt redox-dependent pathways in cells and inhibit oxidative stress related proteins. Its multifunctional mode of action, including its magnetic resonance imaging detectability, provides the opportunity for Xcytrin to be used in a broad range of cancers.

About Pharmacyclics

Pharmacyclics is a pharmaceutical company developing innovative products to treat cancer and other serious diseases. The company is leveraging its small-molecule drug development expertise to build a pipeline in oncology and other diseases based on a wide range of targets, pathways and mechanisms. Its lead product, Xcytrin(R), has completed Phase 3 clinical trials and several ongoing Phase 1 and Phase 2 clinical trials are evaluating Xcytrin, either as a single agent or in combination with chemotherapy and/or radiation in multiple cancer types. More information about the company, its technology, and products can be found at http://www.pharmacyclics.com. Pharmacyclics(R), Xcytrin(R) and the "pentadentate" logo(R) are registered trademarks of Pharmacyclics, Inc.

CONTACT: Leiv Lea of Pharmacyclics, Inc., +1-408-774-0330; or CarolynBumgardner Wang of WeissComm Partners, +1-415-946-1065, for Pharmacyclics,Inc.

Web site: http://www.pharmacyclics.com/

Ticker Symbol: (NASDAQ-NMS:PCYC)

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Posted: May 2007

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