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Pharmacyclics Announces Presentations on Its Novel BTK and HDAC Inhibitors at the American Society of Hematology 49th Annual Meeting

SUNNYVALE, Calif., November 29, 2007 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. today announced multiple presentations and published abstracts regarding its novel Bruton's tyrosine kinase (BTK) inhibitor and histone deacetylase (HDAC) inhibitor compounds. The presentations will take place at the American Society of Hematology (ASH) 49th Annual Meeting, in Atlanta, GA, December 8-11, 2007.

    The presentations and published abstracts are as follows:


    Saturday, December 8, 2007

    Session: Lymphoma: Pre-Clinical: Chemotherapy and Biologic Agents I

    Poster Presentation: Development of RAD51 as Biomarker for Sensitivity to

     the Histone Deacetylase (HDAC) Inhibitor PCI-24781 in Lymphoma

    Abstract #1377: 5:30 p.m. - 7:30 p.m. ET

    Location: Hall B4

    Presenter: Sriram Balasubramanian, Ph.D.; Pharmacyclics, Inc.


    Session: Molecular Pharmacology: Novel Therapies

    Poster Presentation: Targeting Btk in Lymphoma: PCI-32765 Inhibits Tumor

     Growth in Mouse Lymphoma Models and a Fluorescent Analog of PCI-32765 is

     an Active-Site Probe that Enables Assessment of Btk Inhibition in vivo

    Abstract #1592: 5:30 p.m. - 7:30 p.m. ET

    Location: Hall B4

    Presenter: Lee Honigberg, Ph.D.; Pharmacyclics, Inc.


    Session: Chronic Myeloid Leukemia: Biology and Pathophysiology I

    Poster Presentation: Bruton's Tyrosine Kinase (BTK) is not Required for

.    BCR-ABL-Mediated Transformation of Hematopoietic Cells

    Abstract #1015: 5:30 p.m. - 7:30 p.m. ET

    Location: Hall B4

    Presenter: Mary MacPartlin, Ph.D.; Oregon Health & Science University

               Cancer Institute


    Monday, December 10, 2007

    Session: Non-Hodgkin's Lymphoma: Biology-T-Cell and B-Cell

    Poster Presentation: Histone Deacetylase Inhibitor (HDACi) PCI-24781 and

     Bortezomib Result in Synergistic Apoptosis in Hodgkin's Lymphoma (HL) and


     Non-Hodgkin's Lymphoma (NHL) Cell Lines: Investigation of Cell Death and

     NFKB Mediated Pathways

    Abstract #3589: 5:00 p.m. - 7:00 p.m. ET

    Location: Hall B4

    Presenter: Savita Bhalla, Ph.D.; Division of Hematology/Oncology,

     Northwestern University Feinberg School of Medicine and the Robert H.

     Lurie Comprehensive Cancer Center


All abstracts are currently available online at http://www.abstracts2view.com/hem07, and appear in the November 16, 2007 issue of Blood, The Journal of The American Society of Hematology.

About Pharmacyclics

Pharmacyclics is a pharmaceutical company developing innovative products to treat cancer and other serious diseases. The company is leveraging its small-molecule drug development expertise to build a pipeline in oncology and other diseases based on a wide range of targets, pathways and mechanisms. Its lead product, Xcytrin(R) (motexafin gadolinium) Injection, has completed Phase 3 clinical trials and several ongoing Phase 1 and Phase 2 clinical trials are evaluating Xcytrin, either as a single agent or in combination with chemotherapy and/or radiation in multiple cancer types. A New Drug Application for use of Xcytrin in combination with whole brain radiation therapy for treatment of brain metastases from non-small cell lung cancer was filed with the Food and Drug Administration in April 2007. More information about the company, its technology, and products can be found at http://www.pharmacyclics.com. Pharmacyclics(R), Xcytrin(R) and the "pentadentate" logo(R) are registered trademarks of Pharmacyclics, Inc.

CONTACT: Leiv Lea of Pharmacyclics, Inc., +1-408-774-0330; or CarolynBumgardner Wang of WeissComm Partners, +1-415-946-1065, for Pharmacyclics,Inc.

Web site: http://www.pharmacyclics.com/

Ticker Symbol: (NASDAQ-NMS:PCYC)

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Posted: November 2007

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