Pill Identifier App

Nanoviricides Go Beyond Antibodies in Fighting Bird Flu

WEST HAVEN, Conn.--(BUSINESS WIRE)--Sep 17, 2007 - NanoViricides, Inc. (OTC BB: NNVC.OB) (the "Company"), said it will be presenting new preclinical data at the 5th International Bird Flu Conference in Las Vegas on September 28th.

"Just like antibodies, nanoviricides(TM) have ligands that attach to the virus particle. However, unlike antibodies, nanoviricides complete the task of taking the virus apart. This is clearly visible in our electron microscopy (EM) studies," said Anil R. Diwan, Ph.D., President of the Company.

"We feel that nanoviricides are the next great advance beyond immunotherapeutics, (use of antibodies and gamma-globulins as treatments for diseases)," explained Dr. Eugene Seymour, MD, MPH, adding, "We have already shown that nanoviricides are superior to FDA approved antibodies in a rabies animal model. This has validated our approach as being the next evolutionary therapeutics platform after antibodies."

"Nanoviricides do not suffer from the major problems of antibodies and of vaccines as antiviral strategies," said Dr. Diwan. Antibodies are relatively specific to a particular virus strain or subtype. It is well known that HIV and influenza viruses among many others, quickly escape antibodies. Vaccines depend upon the development of antibodies by the host, and thus, cannot protect efficiently against such changed viruses, as evidenced for influenzas.

FluCide(TM)-I is a broad-spectrum nanoviricide drug candidate based on a well-known ligand to which influenza viruses of all types must bind and cannot escape. Many other viruses and virus families also bind to this ligand and FluCide-I is expected to work against such viruses as well.

FluCide-HP is a broad-spectrum nanoviricide drug candidate based on well known "signature regions" called "polybasic sites" on all HPAI influenzas including H5N1 and H7N3. If the virus mutates in this region to escape FluCide-HP, its pathogenicity will decrease and it will no longer be a dangerous epidemic threat. FluCide-HP has also shown very high efficacy against the unrelated rabies virus, which possesses similar signature regions.

"Our next step will be to perform animal studies against H5N1 to further validate our results," said Dr. Seymour, adding, "There have been delays in the commissioning of the BSL3+ animal facility in Vietnam. We are currently exploring other options that would permit the studies to be done in the US with the latest available H5N1 strain."

EM photographs of nanoviricides dismantling virus particles are on the Company's website (http://www.nanoviricides.com/action_small.html).

About NanoViricides:

NanoViricides, Inc. (www.nanoviricides.com) is a development stage company that is creating special purpose nanomaterials for viral therapy. The Company's novel nanoviricide(TM) class of drug candidates are designed to specifically attack enveloped virus particles and to dismantle them. The Company is developing drugs against a number of viral diseases including H5N1 bird flu, seasonal influenza, HIV, hepatitis C, rabies, dengue fever, among others.

This press release contains forward-looking statements that reflect the Company's current expectation regarding future events. Actual events could differ materially and substantially from those projected herein and depend on a number of factors. Certain statements in this release, and other written or oral statements made by NanoViricides, Inc. are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such forward looking statements are subject to known and unknown risks, uncertainties and other factors including the availability of adequate financing, the success of the Company's research and development strategy, the successful and timely completion of clinical studies and the uncertainties related to the regulatory process, described in the "Management's Discussion and Analysis" section of the Company's Form 10-KSB and other reports and filings with the Securities and Exchange Commission. Such risks, uncertainties and other factors may cause actual results, performance, or achievements of the Company to be different from those expressed or implied by the Company.

Contact

NanoViricides, Inc.
Amanda Schuon, 310-550-7200
info@nanoviricides.com

Posted: September 2007

View comments

Hide
(web4)