Meta-analysis of interferon alfa studies cited as
Improved survival in patients with deadliest form of skin cancer
KIRKLAND, QC, Jan. 31 /CNW Telbec/ - The American Society of Clinical Oncology (ASCO), the world's leading professional organization representing physicians who care for people with cancer, cited an interferon alfa meta-analysis as a "Notable Advance" in Clinical Cancer Advances 2010: ASCO's Annual Report on Progress Against Cancer. The report published in the Journal of Clinical Oncology identifies studies that significantly altered the way cancer is understood or had the greatest impact on patient care.1
Melanoma is the deadliest form of skin cancer and the incidence of melanoma has climbed faster than any other type of cancer in the last three decades, according to the ASCO report.2 In Canada, an estimated 5,300 cases of melanoma were diagnosed in 2010. While the incidence increases with age, it is also one of the most common cancers among adolescents and young adults. In Canada, melanoma is the third most common cancer in females aged 15-29 and the fourth most common cancer in males aged 15-29.3
The cited meta-analysis4 of 14 clinical trials involving 8,122 patients with high-risk melanoma showed that adding interferon alfa after surgery improves overall survival in patients with melanoma.5
"The ASCO report covers the most significant cancer advances and mentions that many recent studies have focused on approaches that activate the immune system against melanoma, such us interferon alfa," said Dr. Joël Claveau, dermatologist. "As melanoma is the deadliest form of skin cancer, the results of this meta-analysis represent important resources for physicians dealing with this growing public health problem in Canada."
Clinical Cancer Advances 2010: ASCO's Annual Report on Progress Against Cancer was developed under the guidance of a 14-person editorial board made up of leading oncologists, including specialty editors for each of the disease- and issue-specific sections. Editors reviewed studies in peer-reviewed scientific journals and the results of research presented at major scientific meetings from October 2009 through September 2010. Only studies that significantly altered the way a cancer is understood or had an important impact on patient care were selected for the report.6
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1 Kris MG et al. Clinical Cancer Advances 2010: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology. Published ahead of print on November 15, 2010 as 10.1200/JCO.2010.33.2742. P. 14.
2 Kris MG et al. Clinical Cancer Advances 2010: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology. Published ahead of print on November 15, 2010 as 10.1200/JCO.2010.33.2742. P. 14.
3 Canadian Partnership Against Cancer, Working to halt the increase of skin cancer in Canada [Online] (Updated July 30, 2010).
4 Mocellin S et al. Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis. JNCI 2010; 102 (7): 493-501.
5 Kris MG et al. Clinical Cancer Advances 2010: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology. Published ahead of print on November 15, 2010 as 10.1200/JCO.2010.33.2742. P. 14.
6 Asco Connection, ASCO Releases 2010 Clinical Cancer Advances Report. Available at: http://connection.asco.org/Forums/ASCOConnectionForums/tabid/79/afv/topic/aff/2/aft/346/Default.aspx
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Posted: February 2011