iCo Therapeutics Provides iCo-009 (Oral Amphotericin B) Pharmacokinetic Results
VANCOUVER, Oct. 9 /CNW/ - iCo Therapeutics Inc. (TSX-V: ICO) is pleased to announce a series of positive experiments investigating the systemic bioavailability of amphotericin B following oral administration. iCo-009 is iCo's oral formulation of Amphotericin B, a broad spectrum antifungal drug which currently can only be delivered by intravenous (IV) infusion. Results indicate that oral administration of iCo-009 results in blood levels that are comparable to a known IV Amphotericin B product currently on the market.
In both aspergillus fumigatus and candida albicans rat models, iCo-009 has shown significant antifungal activity with no observable kidney toxicity as assessed by serum creatinine concentrations. Preclinical studies profiling the tissue distribution of iCo-009 in the kidney, liver, spleen, lung, brain and heart are currently underway.
"These studies are encouraging as they help us gain further understanding of the potential of iCo-009 and the underlying drug delivery technology," stated Andrew Rae, iCo's President & CEO. "To show comparable blood levels to existing commercial versions of Amphotericin B, which are administered via IV infusion, is exciting to us as there is a clear commercial and medical need for an oral antifungal with the strength and breadth of action of Amphotericin."
iCo-009 was developed by Drs. Kishor & Ellen Wasan at the University of British Columbia. iCo Therapeutics acquired the worldwide exclusive rights to iCo-009 from UBC in May 2008.
About iCo Therapeutics
iCo Therapeutics Inc. is a Vancouver-based reprofiling company focused on redosing or reformulating drugs with clinical history for new or expanded indications. iCo has exclusive worldwide rights to three products, iCo-007, in Phase I for the treatment of Diabetic Macular Edema, iCo-008, a product with Phase II clinical history to be developed for severe ocular allergies, and iCo-009, an oral reformulation of Amphotericin B for sight and life - threatening diseases. iCo-009 also represents a new drug delivery technology with the potential to reprofile other parenterally administered drugs to the oral route of administration. iCo Therapeutics trades on the TSX-Venture exchange under the symbol "ICO". For more information, visit the company website at: www.icotherapeutics.com.
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Forward Looking Statements
Certain statements included in this press release may be considered forward-looking. Such statements involve known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by such statements, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on iCo Therapeutics' current beliefs as well as assumptions made by and information currently available to iCo Therapeutics and relate to, among other things, anticipated financial performance, business prospects, strategies, regulatory developments, market acceptance and future commitments. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by iCo Therapeutics in its public securities filings; actual events may differ materially from current expectations. iCo Therapeutics disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
%SEDAR: 00024061E -30- /For further information: Business Development: Dr. John Clement, CBO, (604) 602-9414 x 222; Finance Contact: Mr. John Meekison, CFO, (604) 602-9414 x 224; Investor, Media Contact: Frederica Bell, Corp. Dev't., (604) 602-9414 x 228; B&D Capital, Joanne Calverley, (604) 685-6465/
Posted: October 2008