EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACRAnnual MeetingCompounds Demonstrate Potent Antitumor Activity in a Variety of Tumor Types
ROCKVILLE, Md., April 16, 2008 /PRNewswire-FirstCall/ -- EntreMed, Inc. , a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the presentation of preclinical results for two of its clinical stage compounds, MKC-1 and ENMD-1198. Presentations were given by EntreMed scientists during two poster sessions at the American Association for Cancer Research (AACR) Annual Meeting being held this week in San Diego, California.
MKC-1 administered in combination with paclitaxel in a preclinical, orthotopic breast tumor model demonstrated synergistic tumor inhibition. The combination of MKC-1 and paclitaxel, but neither agent alone, demonstrated tumor regression of the bulky breast cell line tumors grown in this model. In addition, the combination decreased angiogenesis and proliferation, and increased apoptosis as early as 4 days post treatment. Treatment with the combination also decreased the oncogenic proteins HIF-1alpha, pAKT, and pS6 ribosomal proteins.
In a second presentation, treatment of the 1A9 human ovarian carcinoma cell line with ENMD-1198 induced cell cycle arrest and decreased levels of the oncogenic transcription factor proteins HIF-1alpha, pSTAT3, and pNFkappaB. Treatment with ENMD-1198 also downregulates expression of several tubulin isotypes in 1A9 cells, but not in ENMD-1198-resistant (1A9-1198R) cells. This, combined with the relative lack of inhibition of oncogenic proteins observed in 1A9-1198R cells, suggests interaction with tubulin may be important for the modulation of oncogenic proteins by ENMD-1198. In summary, data demonstrate that ENMD-1198 resistant 1A9 cells may provide a useful tool for evaluating a pharmacogenomic profile that can be correlated with clinical benefit.
Dr. Bray commented on the presentations, "We continue to see encouraging potent preclinical antitumor activity with MKC-1 and ENMD-1198. Although both compounds are currently in multiple clinical trials in oncology, these robust preclinical data further support and strengthen our knowledge of their mechanisms of action. Development of MKC-1 and ENMD-1198 is in line with the Company's focus on orally available, small molecule drugs for the treatment of cancer and inflammatory diseases. MKC-1 is currently in multiple Phase 1 and 2 clinical trials and ENMD-1198 is in a Phase 1 study in advanced cancers. Additional clinical studies are planned for both compounds in 2008."
EntreMed, Inc. is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflammation. MKC-1 is currently in multiple Phase 2 clinical trials for cancer. MKC-1 is an oral cell-cycle regulator with activity against the mTOR pathway. ENMD-1198, a novel antimitotic agent, and ENMD-2076, a selective kinase inhibitor, are in Phase 1 studies in advanced cancers. The Company also has an approved IND application for Panzem(R) in rheumatoid arthritis. EntreMed's goal is to develop and commercialize new compounds based on the Company's expertise in angiogenesis, cell-cycle regulation and inflammation - processes vital to the treatment of cancer and other diseases, such as rheumatoid arthritis.
Forward Looking Statements
This release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act with respect to the outlook for expectations for future financial or business performance (including the timing of royalty revenues and future R&D expenditures), strategies, expectations and goals. Forward-looking statements are subject to numerous assumptions, risks and uncertainties, which change over time. Forward-looking statements speak only as of the date they are made, and no duty to update forward-looking statements is assumed. Actual results could differ materially from those currently anticipated due to a number of factors, including those set forth in Securities and Exchange Commission filings under "Risk Factors," including risks relating to the need for additional capital and the uncertainty of additional funding; variations in actual sales of Thalomid(R), risks associated with the Company's product candidates; the early-stage products under development; results in preclinical models are not necessarily indicative of clinical results, uncertainties relating to preclinical and clinical trials; success in the clinical development of any products; dependence on third parties; future capital needs; and risks relating to the commercialization, if any, of the Company's proposed products (such as marketing, safety, regulatory, patent, product liability, supply, competition and other risks).
CONTACT: Ginny Dunn Associate Director, Corporate Communications & Investor Relations EntreMed, Inc. 240.864.2643
Posted: April 2008