Elixir Pharmaceuticals Announces Presentation of Data in Programs to Treat and Prevent Metabolic Diseases
In addition, Elixir has established a leading position in the research of sirtuins, a class of proteins that have been implicated in the control of transcription factors and other functions that control glucose homeostasis and fat mobilization. These data suggest that regulation of these enzymes may also play a key role in the treatment of metabolic disease. Elixir has undertaken seminal research in this area and is currently evaluating a number of proprietary, potent sirtuin activators and inhibitors for their potential to address diverse metabolic and age-related diseases.
Dr. DiStefano will make his presentation at the SRI meeting at 2:30pm Pacific on Tuesday, July 17.
Elixir's Ghrelin Antagonist Program
-- Elixir researchers have demonstrated that "knockout" mice missing the gene for the ghrelin receptor (GhrR) resist diet-induced obesity and diabetes. After 15 weeks on a high fat diet, the normal (control) mice gained 10 percent more weight than GhrR knockout mice while on the same diet. The majority of the weight difference was observed in white adipose tissue. Strikingly, liver fat content was significantly lower and liver function was improved (as measured by liver enzyme levels) in the knockout mice when compared to the control mice. Additionally, the knockout mice had significantly lower blood glucose, insulin and HbA1c levels compared to normal ('wild-type') mice with the gene.
-- In subsequent studies, Elixir scientists compared the results of the GhrR knockout mice to those obtained with mice treated twice a day for up to 56 days with EX-1350, Elixir's potent, small-molecule, oral GhrR antagonist. As with the GhrR knockout mice, the antagonist-treated mice on a high-fat diet showed lower body weight as well as improved glucose and insulin homeostasis compared to control mice treated with vehicle. Liver fat content also decreased significantly and liver function improved relative to vehicle-treated (control) mice. The results demonstrate that GhrR antagonist treatment of normal high fat-fed mice recapitulates the phenotype of the high fat-fed GhrR knockout mice.
Elixir's Sirtuin Program
-- In-vitro and in-vivo (animal) studies demonstrate that targeting the human SIR T enzymes with small-molecule modulators may have clinical utility across a wide range of disease states, including metabolic disease.
-- Elixir has extensive expertise and know-how in sirtuin biology and broad intellectual property. The Company is currently characterizing its SIR T1 activators (five different chemical classes) in in-vivo models of metabolic disease.
Dr. DiStefano commented, "Elixir has a highly diverse therapeutic platform based on the intersecting biochemical pathways that contribute to metabolic disease and aging. We believe ghrelin inhibition will represent a significant advance for the treatment of serious and debilitating metabolic disorders such as Type 2 diabetes and obesity. We also believe that our research in sirtuins has significantly advanced the understanding in this area and represents another exciting set of targets for the identification and development of novel compounds to treat metabolic disease."
About Elixir Pharmaceuticals
Elixir is a Cambridge, MA-based biopharmaceutical company focused on developing and commercializing drugs to treat and prevent metabolic disease and prevent age-related diseases, ultimately extending the quality and length of human life.
The Company's ghrelin antagonist, EX-1350, is a proprietary, small molecule designed to bind to the human ghrelin receptor. Elixir has filed broad intellectual property protection on all aspects of the ghrelin antagonist program, including composition of matter protection covering five novel compound classes and their therapeutic uses.
In addition to its ghrelin antagonist program, the Company has leveraged its knowledge of ghrelin biology and pharmacology by licensing a small molecule ghrelin agonist (designated EX-1314) from Bristol-Myers Squibb Company in April 2005. EX-1314 binds selectively to the ghrelin receptor and mimics the body's naturally occurring ghrelin. In doing so, this novel, orally available agent is capable of stimulating appetite, gastric motility and the release of growth hormone. Elixir is currently in IND-enabling studies with EX-1314 targeting a variety of therapeutic indications.
Further, in March 2006, Elixir in-licensed North and South American rights to Glufast(R) (mitiglinide calcium hydrate), an insulin secretagogue, which lowers post-meal glucose levels by improving the body's own ability to produce insulin. Already marketed in Japan, Glufast has undergone extensive clinical development demonstrating the product's ability to safely and effectively treat Type 2 diabetes. Elixir most recently announced clinical results of Glufast monotherapy and combination therapy with metformin during the American Diabetes Association 67th Annual Scientific Sessions in June 2007.
Elixir has also developed expertise and a broad IP portfolio of more than 20 patents and patent applications related to the Sirtuin class of proteins, including small molecular weight SIRT1 activators and inhibitors. Elixir is also actively pursuing drug discovery efforts focused on other key targets, such as AMP-activated kinase (AMPK), which Elixir has shown to be implicated in the regulation of aging and metabolism in a variety of organisms.
More information about Elixir is available at http://www.elixirpharm.com/
William Heiden, 617-995-7000
Burns McClellan for Elixir Pharmaceuticals:
Justin Jackson, 212-213-0006
Jason Farber, 212-213-0006
Juliane Snowden, 212-213-0006
Nicki Kahner, 212-213-0006
Posted: July 2007