Data on PolyMedix Heptagonist Compounds Presented at the International Society on Thrombosis and Hemostasis (ISTH) Conference

RADNOR, Pa.--(BUSINESS WIRE)--Jul 17, 2009 - PolyMedix, Inc. (OTC BB: PYMX,, an emerging biotechnology company developing acute care products for infectious diseases and acute cardiovascular disorders based on biomimetics, announced that three posters relating to the Company's heptagonist compounds were presented at the International Society on Thrombosis and Hemostasis Conference. The posters were presented at the conference on July 16, 2009, by PolyMedix's collaborators at Loyola University.

Titled “In Vitro Characterization of the Neutralization of Low Molecular Weight Heparin and Heparin-Like Drugs by Novel Salicylamide Derivatives”, “In Vivo Neutralization of Unfractionated Heparin and Low Molecular Weight Heparin by a Novel Salicylamide Derivative”, and “Ex Vivo Neutralization of Enoxaparin in Primates by a Novel Heparin Antagonist”, the posters described a series of laboratory and animal studies with various PolyMedix heptagonist compounds, including PMX-60056, and described their abilities to reverse the activities of low molecular weight heparin, fondaparinux, and unfractionated heparin. The poster presentations will be made available on PolyMedix's website at

PolyMedix's lead heptagonist compound is PMX-60056, currently in Phase I clinical development. PMX-60056 is a novel small-molecule drug candidate designed to block the anticoagulant action of heparin and low molecular weight heparins (LMWH), clot prevention drugs which are commonly used in a number of applications. On March 11, 2009 PolyMedix announced the successful completion of a Phase I clinical study with PMX-60056. The data from that study demonstrated that single intravenous doses can be given at levels that will support the planned follow-on therapeutic proof-of-concept Phase IB clinical trial. Further clinical development is expected to continue for this drug as an agent for the rapid reversal of heparin after surgery, and for emergencies where heparin anticoagulation presents a clinical problem.

Heparin and LMWH are widely used anticoagulants, drugs to prevent blood clotting. However, they have the risk of potentially serious bleeding side effects. Protamine is currently the only approved drug used to reverse the action of heparin, and there is no approved reversing agent for LMWH. However, there are serious potential side effects associated with protamine. Based on preclinical studies conducted by PolyMedix and its collaborators, potential advantages of PMX-60056 over protamine may include reduced bleeding complications, reduced risk of immune-mediated side effects, and the ability to neutralize LMWH.

PMX-60056 was designed to bind to the pentasaccharide region found on heparin. PMX-60056 is believed to form a stable electrostatic bond to heparin, blocking its action. This molecular combination is believed to persist until removed from circulation by normal processes. In previous studies conducted by PolyMedix and other groups, PMX-60056 has been demonstrated to reverse the action of heparin and low molecular weight heparin in isolated human plasma, isolated human whole blood, and in animal studies in rats, dogs, and primates.

About PolyMedix, Inc.

PolyMedix is a publicly traded emerging biotechnology company focused on the development of novel drugs and biomaterials for the treatment of infectious diseases and acute cardiovascular disorders. PolyMedix's compounds are based on biomimetics: non-peptide small molecule drug candidates that mimic the activity of proteins. The Company's antibiotic compounds, including PMX-30063 – small molecule mimetics of human host-defense proteins - have a mechanism of action distinct from those of current antibiotic drugs, a mechanism which is intended to make bacterial resistance unlikely to develop. The Company's goal is to develop these as rapidly acting antibiotics for serious systemic and local infections. The Company plans to continue the development of polymeric formulations as antimicrobial biomaterials, which can be used as additives to paints, plastics, and textiles to create self-sterilizing products and surfaces. The Company's heptagonist compounds, including PMX-60056, reverse the activity of both heparin and Low Molecular Weight Heparins, with the goal of developing an antagonist drug that is safer and easier to use than currently approved therapy for heparin. For more information, please visit PolyMedix on its website at

This press release contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 that involve risks, uncertainties and assumptions that could cause PolyMedix's actual results and experience to differ materially from anticipated results and expectations expressed in these forward looking statements. PolyMedix has in some cases identified forward-looking statements by using words such as “anticipates,” “believes,” “hopes,” “estimates,” “looks,” “expects,” “plans,” “intends”, “goal”, “potential,” “may,” ”suggest,” and similar expressions. Among other factors that could cause actual results to differ materially from those expressed in forward-looking statements, PolyMedix's compounds may not enter or successfully complete clinical testing or be granted regulatory approval to be sold and marketed in the United States or elsewhere. A more complete description of these factors is included in PolyMedix's filings with the Securities and Exchange Commission. You should not place undue reliance on any forward-looking statements. PolyMedix undertakes no obligation to release publicly the results of any revisions to any such forward-looking statements that may be made to reflect events or circumstances after the date of this press release or to reflect the occurrence of unanticipated events, except as required by applicable law or regulation.



Contact: PolyMedix, Inc.
Lona Cornish, 484-598-2340
The Investor Relations Group
Erika Moran, 212-825-3210
Janet Vasquez, 212-825-3210



Posted: July 2009

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