Data on the Anti-inflammatory Activity of Cempra Pharmaceutical's CEM-101 Will be Presented at the American Thoracic Society 2010 International Conference

CHAPEL HILL, N.C., May 13 /PRNewswire/ -- Cempra Pharmaceuticals today announced the schedule of poster presentations on its next-generation macrolide, CEM-101, at the American Thoracic Society (ATS) 2010 International Conference in New Orleans, Louisiana, on May 14 to 19, 2010.
 

Both posters will be presented during the poster session entitled "C41 Emerging Pharmacology for Chronic Obstructive Pulmonary Disease: Mechanisms and Outcomes" scheduled for 8:15 a.m. to 4:00 p.m. CDT on Tuesday, May 18.
 

Cempra Pharmaceuticals ATS 2010 International Conference Schedule At-A-Glance
 

  Tuesday, May 18, 2010


   -- Poster Presentation: "A novel macrolide/ fluoroketolide, CEM-101,
  reverses corticosteroid insensitivity under oxidative stress, via PI3K pathway inhibition"
  Time: On display: 8:15 a.m. to 4:00 p.m. CDT, Poster # 3527
  Location: F62, Area F, Hall G
  Y. Kobayashi, C. Rossios, D. Takagi, P.J. Barnes, K. Ito (Airway Disease
  Section, NHLI, Imperial College London, UK)

   -- Poster Presentation: "Superior anti-inflammatory effects of a novel
  macrolide/fluoroketolide, CEM-101 in monocytic cells"
  Time: On display: 8:15 a.m. to 4:00 p.m. CDT, Poster # 3506
  Location: F63, Area F, Hall G
  Y. Kobayashi, C. Rossios, P.J. Barnes, K. Ito (Airway Disease Section,
  NHLI, Imperial College London, UK)


  About CEM-101

CEM-101 is a next generation macrolide with a number of attributes that may provide clinically important advantages over several comparator products:
 

  --  Potent activity, in vitro and in vivo, against all important pathogens
      that cause community-acquired bacterial pneumonia, including
      pneumococci, as well as potent activity against a broad spectrum of
      other serious pathogens including CA-MRSA, M. avium, malaria, atypical
      bacteria such as Legionella, Mycoplasma, Chlamydophila, and Neisseria
  --  CEM-101 is generally 8 to 16 times more potent than azithromycin and
      is active against organisms that have become resistant to azithromycin
  --  Novel structure and mechanism of action with additional binding sites
      on the bacterial ribosome that confers activity against erm- and
      mef-resistant strains
  --  Good tolerability in phase 1 trials
  --  Low resistance frequency in vitro
  --  Excellent tissue distribution and intracellular tissue concentrations
  --  Oral and IV formulations
  --  Once-daily dosing
  --  Potential for indications beyond CABP, including urethritis and other
      urogenital infections, bioterrorism targets, malaria, M. avium
      infections and tuberculosis

The annual incidence for pneumonia in the United States is over 5 million patients each year. There is a growing need for new drugs to address the issues of drug resistance, tolerability, and administration associated with currently available treatments. Cempra has licensed exclusive worldwide rights from Optimer Pharmaceuticals, Inc., except in the Association of Southeast Asian Nations (ASEAN) countries, to discover, develop and commercialize macrolides from a library of more than 500 compounds from Optimer's OPopS drug discovery platform.
 

About Cempra Pharmaceuticals
 

Founded in 2006, Cempra Pharmaceuticals is a privately-held, clinical-stage pharmaceutical company focused on developing antibacterials to address critical medical needs. Two lead products, both in late-stage clinical trials, address the urgent and increasing need for new treatments targeting drug-resistant bacterial infections in the hospital and in the community. Cempra is well-funded and is committed to developing commercially and medically differentiated and novel products that reduce development risk and provide a high financial return. The company is also utilizing its proprietary compound library and chemistry technology to develop novel macrolides without antibacterial activity for non-antibiotic uses such as COPD, chronic inflammatory and GI disorders. Additional information about Cempra can be found at www.cempra.com.
 

  Media Contacts:
  Robert E. Flamm, Ph.D.
  Russo Partners, LLC
  (212) 845-4226
  Robert.flamm@russopartnersllc.com

  Tony Russo, Ph.D.
  Russo Partners, LLC
  (212) 845-4251
  Tony.russo@russopartnersllc.com

Source: Cempra Pharmaceuticals

CONTACT: Robert E. Flamm, Ph.D., Russo Partners, LLC, +1-212-845-4226,
Robert.flamm@russopartnersllc.com; Tony Russo, Ph.D., Russo Partners, LLC,
+1-212-845-4251, Tony.russo@russopartnersllc.com
 

Web Site: http://www.cempra.com/
 

Posted: May 2010

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