CuraGen Announces New Preclinical Results with Belinostat and Velafermin to be Presented at AACR Annual Meeting
BRANFORD, Conn., April 12, 2007 /PRNewswire-FirstCall/ -- CuraGen Corporation announced today that new preclinical data on belinostat (PXD101), a histone deacetylase (HDAC) inhibitor being investigated for the treatment of cancer, and velafermin, a protein being investigated for the prevention of severe oral mucositis, will be presented at the upcoming American Association for Cancer Research (AACR) 2007 Annual Meeting in Los Angeles, CA, April 14-18, 2007. A total of five poster presentations on belinostat (PXD101) and one poster presentation on velafermin will be made during the conference.
Belinostat (PXD101), HDAC inhibitor for the treatment of cancer: -- "Activity of PXD101, an HDAC inhibitor, used alone or in combination with 5-FU in preclinical gastroesophageal studies," (Abstract #691) during the conference's HDAC Inhibitors I poster session on Sunday, April 15th in the Exhibit Hall, Poster Section 28 on Poster Board #14 -- "Gene expression screen in cell panel selected for varying sensitivity towards the Histone Deacetylase inhibitor (HDACi) PXD101 reveals potential predictors of HDACi sensitivity," (Abstract #687) during the conference's HDAC Inhibitors I poster session on Sunday, April 15th in the Exhibit Hall, Poster Section 28 on Poster Board #10 -- "The effect of the histone deacetylase inhibitor (HDACi) PXD101 on cell growth and expression of viral and host genes in hepatitis B virus (HBV)-carrying hepatocellular carcinoma (HCC) cell lines," (Abstract #696) during the conference's HDAC Inhibitors I poster session on Sunday, April 15th in the Exhibit Hall, Poster Section 28 on Poster Board #19 -- "The histone deacetylase (HDAC) inhibitor PXD101 suppresses bladder cancer cell growth both in-vitro and in-vivo," (Abstract #2211) during the conference's Mouse Models of Cancer 2: Therapeutic Approaches poster session on Monday, April 16th in the Exhibit Hall, Poster Section 23 on Poster Board #9 -- "The HDAC inhibitors romidepsin and PXD101 interact synergistically with Bortezomib in human chronic lymphocytic leukemia (CLL) cells in association with NF-.B inactivation," (Abstract #1835) during the conference's Targeted Agents and Other Novel Therapies poster session on Monday, April 16th in the Exhibit Hall, Poster Section 7 on Poster Board #21 Velafermin, protein for the prevention of severe oral mucositis: -- "Velafermin (rhFGF-20) reduces fractionated radiation- induced oral mucositis in hamsters," (Abstract #3758) during the conference's Cytosolic Signaling 2 poster session on Tuesday, April 17th in the Exhibit Hall, Poster Section 16 on Poster Board #15. About CuraGen
CuraGen Corporation is a biopharmaceutical company developing diverse approaches, including novel protein, antibody, antibody- drug conjugate and small molecule therapeutics. By leveraging the drug development strengths cultivated over the years, CuraGen expects to make a difference by advancing its promising therapeutics to address the unmet medical needs of patients with cancer and inflammatory diseases. CuraGen is focused on bringing velafermin, belinostat and CR011-vcMMAE through clinical development, and maintains a portfolio of earlier-stage compounds that have the potential to treat cancer and inflammatory diseases. CuraGen Corporation is headquartered in Branford, Connecticut. For additional information please visit www.curagen.com.
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Posted: April 2007