Celera Publishes Review Article on the KIF6 Gene Variant as a Predictor of Risk of Coronary Heart Disease (CHD) and Reduction in Coronary Events from Statin Therapy
Carriers of the risk variant were at greater risk of CHD events, and statin therapy significantly reduced coronary events in carriers but not in noncarriers
ALAMEDA, CA - August 18, 2010-Celera Corporation (NASDAQ:CRA) today announced the publication of a review article on the KIF6 gene variant as a predictor of risk of coronary heart disease (CHD) and reduction of CHD events from statin therapy. This review of multiple studies of over 50,000 people included a meta-analysis of 7 prospective studies showing that a variant of the KIF6 gene is strongly associated with increased risk of CHD (P value = 1x10-6). These included the results of genetic studies of 4 landmark prospective, randomized clinical trials, the gold standard for clinical research, in which it was found that statin therapy significantly reduced CHD events in KIF6 719Arg carriers, but not in noncarriers. This review has been published ahead of print in the American Journal of Cardiology, and is currently available on the publication’s website at: http://www.ajconline.org/article/S0002-9149(10)01138-0/abstract.
The article summarized multiple independent studies conducted over several years that involved collaborations with a number of academic institutions. Results from prospective studies showing that the KIF6 gene variant was an independent predictor of risk of CHD were reviewed. These studies included the Atherosclerosis Risk in Communities (ARIC) study of 12,556 middle-aged Caucasians and African Americans, the Cardiovascular Health Study of 4,552 Americans aged 65 or older, and the Women's Health Study of 25,283 initially healthy women older than 45 years. The increased risk of CHD events observed in KIF6 carriers was independent of other well-known CHD risk factors, including age, sex, smoking, hypertension, and cholesterol.
The review also summarized results that indicated statin therapy significantly reduced coronary events in carriers of the KIF6 719Arg variant, but not in noncarriers. Three of these clinical trials assessed the effect of pravastatin (Pravachol®) on the prevention of CHD events: the Cholesterol and Recurrent Events (CARE) study; the primary prevention West of Scotland Coronary Prevention Study (WOSCOPS); and the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) . Additionally, a genetic study of PROVE IT-TIMI 22 reported that in patients after an acute coronary syndrome (ACS), high-dose atorvastatin (Lipitor®), compared with standard dose pravastatin, was significantly more effective at reducing CHD events in KIF6 carriers than in noncarriers. To date, the benefits of statin therapy for KIF6 carriers have only been demonstrated with atorvastatin and pravastatin therapy.
The review article further detailed findings that the number of people needed to be treated with a statin to prevent one CHD event was 10 to 20 in KIF6 carriers compared to >80 in noncarriers, suggesting that KIF6 carriers could obtain greater benefit from statin therapy.
“We are pleased with the publication of this comprehensive summary of our KIF6 findings,” said John Sninsky, Ph.D., Vice President of Discovery Research at Celera. “Recently, questions have been raised regarding the substantial investment in genetic studies, including large scale genome-wide association studies (GWAS), and whether these studies have been successful in impacting medicine to date. We believe that part of the explanation for why these studies have not discovered more markers for both disease risk and drug response is that such studies often use a design that includes case and control subjects who may be undergoing drug therapy that mitigates the relevant disease risk. For example, if one were to conduct a case-control study to identify gene variants associated with elevated blood pressure among patients on anti-hypertensive drugs, we believe it is unlikely that such risk variants would be found, and indeed this has been shown by Tobin et al 1.
“In typical case-control studies such as the Ottawa Heart Study, some of the cases had taken a statin prior to their event,” added Dr. Sninsky. “In that study, no association was found between KIF6 and arteriographic evidence for a >50% coronary artery narrowing, which is a different clinical phenotype than the clinical events of CHD examined in the previous KIF6 studies referenced above. Of note, 89% of the cases in the Ottawa study were on statin therapy, which Celera believes may have had an effect on the lack of an association with risk in KIF6 carriers.
“The investigation of the KIF6 variant described in the review article differs from most of the recent GWAS case-control studies in two important ways,” added Dr. Sninsky. “First, the association between the KIF6 variant and risk of CHD was investigated in the placebo group of randomized clinical trials of statin therapy, thereby preventing statin use from masking the risk associated with this gene variant. Second, the association between the KIF6 variant and risk of CHD was further replicated in multiple prospective population-based studies, a type of study that minimizes the ascertainment biases that frequently occur in case-control study designs.”
“Like most other genetic variants recently associated with complex diseases, the precise role KIF6 plays in the pathophysiology of disease is still being delineated,” said James Devlin, Ph.D., Senior Director of Cardiovascular Diseases at Celera. “The KIF6 gene encodes a member of the molecular motor protein kinesin family; data presented earlier this year suggest a potential role for KIF6 in the inflammatory cells of atherosclerotic lesions, lesions that can develop into vulnerable plaques that may rupture and cause CHD events. We believe these findings provide initial insight into a potential mechanism for the role of KIF6 in CHD.”
Celera is a healthcare business focusing on the integration of genetic testing into routine clinical care through a combination of products and services incorporating proprietary discoveries. Berkeley HeartLab, a subsidiary of Celera, offers services to predict cardiovascular disease risk and improve patient management. Celera also commercializes a wide range of molecular diagnostic products through Abbott and has licensed other relevant diagnostic technologies developed to provide personalized disease management in cancer. Information about Celera Corporation, including reports and other information filed by the company with the Securities and Exchange Commission, is available at http://www.celera.com .
Certain statements in this press release are forward-looking. These may be identified by the use of forward-looking words or phrases such as "believe," "plan," and "could," among others. These forward-looking statements are based on Celera Corporation's current expectations. The Private Securities Litigation Reform Act of 1995 provides a "safe harbor" for such forward-looking statements. In order to comply with the terms of the safe harbor, Celera notes that a variety of factors could cause actual results and experience to differ materially from the anticipated results or other expectations expressed in such forward-looking statements. These factors include but are not limited to: (1) the risks that Celera may not receive required regulatory approvals to commercialize a diagnostic product for KIF6 in the United States and other jurisdictions; (2) Celera’s scientific discoveries may not be replicated in studies by other investigators, which may negatively impact the acceptance of the Company’s diagnostic products; (3) Celera is using novel and unproven methods to discover markers for the development of new diagnostic products, which may not be successful; (4) the diagnostic industry is very competitive, and new diagnostic products may not be accepted and adopted by the market; (5) demand for diagnostic products may be adversely affected if users of these products cannot receive adequate reimbursement for these products from third party payors such as private insurance companies and government insurance plans; (6) potential product liability or other claims against Celera as a result of the testing or use of its products; and (7) uncertainty of the availability to Celera of intellectual property protection, limitations on its ability to protect trade secrets, the risk to it of infringement claims, and the possibility that it may need to license intellectual property from third parties to avoid or settle such claims. The foregoing list sets forth some, but not all, of the factors that could affect Celera's ability to achieve results described in any forward-looking statements. For additional information about the risks and uncertainties that Celera faces and a discussion of its financial statements and footnotes, see documents filed by Celera with the SEC, including its annual report on Form 10-K and all subsequent periodic reports. All information in this press release is as of the date of the release, and Celera does not undertake any duty to update this information, including any forward-looking statements, unless required by law.
1. Tobin et al., Statis Med 2005; 24:2911-35.
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Posted: August 2010