BioMS Medical Presents at the 23rd Congress of the European Committee for Treatment and Research in Multiple Sclerosis
EDMONTON, Alberta, Oct. 15, 2007/CNW/ - BioMS Medical Corp.
(TSX: MS), a leading developer in the treatment of multiple
sclerosis (MS), today announced that interim safety
observations from MAESTRO-01, the Company's on-going phase
III trial of MBP8298 for the treatment of secondary
progressive MS, were reported in a poster presentation at the
23rd Congress of the European Committee for Treatment and
Research in Multiple Sclerosis (ECTRIMS) in Prague, Czech
Republic. A second poster presentation reported the percentage of
patients screened for the trial that had the target
HLA-DR2/DR4 immune response
genes.
ECTRIMS is one of the largest and most prestigious annual MS
conferences, bringing together MS experts and thought leaders
from around the world to discuss the latest MS research
findings. The first poster, entitled "Safety observations from
administration of MBP8298 as part of the ongoing phase III
MAESTRO-01 secondary progressive MS clinical trial", showed
that MBP8298 administration resulted in no significant safety
concerns measured over the current course of the MAESTRO-01
study.
The second poster, entitled "Haplotype analysis of Secondary
Progressive Patients participating in the MAESTRO-01 Study",
showed that overall, amongst the 10 countries enrolling
patients in the MAESTRO-01 trial, (Canada, United Kingdom,
Finland, Denmark, Sweden, Estonia, Latvia, Spain, Germany and
the Netherlands) 70.38% of the 788 screened patients were
observed to have HLA-DR2 and/or HLA-DR4 immune response
genes.
"The first poster presentation demonstrates that the safety profile
of our drug continues to look strong in a large multinational
clinical trial setting," said Kevin Giese, President and CEO
of BioMS. "The second poster reaffirms that MS patients with
HLA-DR2/DR4 immune response genes, potentially account for
more than 70% of the overall MS population in Europe and
Canada."
About MBP8298 - Novel Mechanism of
Action
In MS patients, the body's immune system inappropriately attacks
the myelin coating around the nerves in the brain and spinal
column, whereas healthy people are "tolerant" of such normal
body components. The proposed mechanism of action of MBP8298
is, by design, to re-introduce such a state of "tolerance" to
a critical portion of the nerve's Myelin Basic Protein that
is an immunological site of attack in many MS patients. This
is accomplished by the I.V. injection of MBP8298 every six
months.
Phase II and long-term follow-up treatment of MS patients with
MBP8298, recently published in the European Journal of
Neurology showed that MBP8298 safely delayed the median time
to disease progression for five years in progressive MS
patients with HLA-DR2 or HLA-DR4 immune response
genes.
MBP8298 is being developed in three late-stage clinical trials:
- MAESTRO-01: A pivotal phase III trial in Canada
and Western Europe evaluating MBP8298 for the treatment of
secondary progressive multiple sclerosis (SPMS). The trial is
a randomized, double-blind study and is fully recruited with 611
patients.
- MAESTRO-03: A pivotal phase III U.S. trial evaluating
MBP8298 for the treatment of SPMS. The trial is a randomized,
double-blind study enrolling approximately 510
patients.
- MINDSET-01: A phase II trial evaluating MBP8298 for the
treatment of relapsing remitting multiple sclerosis (RRMS).
The trial is a
randomized, double-blind study and is fully recruited with 218
patients.
About BioMS Medical Corp.
BioMS Medical is a biotechnology company engaged in the development and commercialization of novel therapeutic technologies. BioMS Medical's lead technology, MBP8298, is for the treatment of multiple sclerosis and is being evaluated in two pivotal phase III clinical trials for secondary progressive MS patients, MAESTRO-01 in Canada and Europe and MAESTRO-03 in the United States. It additionally is being evaluated for relapsing remitting MS patients in a Phase II trial in Europe entitled MINDSET-01. For further information please visit our website at http://www.biomsmedical.com.
This press release may contain forward-looking statements, which reflect the Company's current expectation regarding future events. These forward-looking statements involve risks and uncertainties that may cause actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements. Such factors include, but are not limited to, changing market conditions, the successful and timely completion of clinical studies, the establishment of corporate alliances, the impact of competitive products and pricing, new product development, uncertainties related to the regulatory approval process and other risks detailed from time to time in the Company's ongoing quarterly and annual reporting. Certain of the assumptions made in preparing forward-looking statements include but are not limited to the following: that MBP8298 will continue to demonstrate a satisfactory safety profile in ongoing and future clinical trials; and that BioMS Medical Corp. will complete the respective clinical trials within the timelines communicated in this release. We undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
For further information: Tony Hesby, Ryan Giese, Corporate Communications, BioMS Medical Corp., (780) 413-7152, (780) 408-3040 Fax, E-mail: rgiese@biomsmedical.com, Internet: http://www.biomsmedical.com; James Smith, Investor Relations, (416) 815-0700 ext. 229, (416) 815-0080 Fax, E-mail: jsmith@equicomgroup.com
Posted: October 2007
