Amgen's Oncology Pipeline Data Highlighted at Upcoming Scientific Meeting

THOUSAND OAKS, Calif.--(BUSINESS WIRE)--Apr 3, 2008 - Amgen (NASDAQ: AMGN) today announced that results from several preclinical and clinical trials investigating cancer treatment will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2008 in San Diego between April 12-16, 2008. Data will be presented on pipeline compounds: AMG 102, AMG 386, AMG 479, AMG 655 and motesanib diphosphate (AMG 706).

At AACR, Amgen will present data from studies investigating the tumor attacking potential of these products - alone or in combination with other therapies. These early studies have provided the biologic evidence to allow Amgen to launch a suite of exploratory Phase 1b/2 programs with these five molecules, across 15 tumor types with more than 30 clinical trials currently underway or planned.

"These data underscore our ongoing exploration of key biological processes that influence the growth of cancer cells including angiogenesis, apoptosis and growth regulation," said David Chang, M.D., vice president, Global Oncology Development at Amgen. "In addition, Amgen is actively pursuing identification of biomarkers that will help the company make better and earlier decisions about pipeline compounds, and enable targeted application of specific therapies to the patients who are more likely to benefit from treatment with them."

Selected Presentations of Interest

Anti-Angiogenesis

A program focused on the development of molecules that will interdict the abnormal process of new blood vessel formation. -0-

-- Combined treatment of angiopoietin and VEGF pathway antagonists

    enhances antitumor activity in preclinical models of colon

    carcinoma.

   Overview: Researchers combined AMG 386 with either bevacizumab or

    motesanib diphosphate (AMG 706) to explore inhibition of the

    VEGF/VEGFR pathways.

   Abstract No. 1113 (Sunday, April 13, 2008, 1:00 PM - 5:00 PM)


-- In-vitro activity of motesanib diphosphate, an inhibitor of VEGFR,

    PDGFR and Kit tyrosine kinases, against imatinib-resistant Kit

    mutations.

   Overview: Researchers tested the activity of motesanib diphosphate

    (AMG 706) a small molecule inhibitor of VEGFR, PDGFR and Kit,

    against primary oncogenic and imatinib-resistant Kit mutations in

    Gleevec(R)-resistant gastrointestinal stromal tumors.

   Abstract No. 4887 (Tuesday, April 15, 2008, 1:00 PM - 5:00 PM)


-- Modulation of radiation response by motesanib diphosphate in models

    of head and neck squamous cell (HNSCC) carcinoma.

   Overview: Researchers explored the benefit of adding AMG 706 to

    radiation therapy in HNSCC models.

   Abstract No. 5764 (Wednesday, April 16, 2008, 8:00 AM - 12:00 PM)

Cancer Cell Apoptosis

A program focused on the development of highly selective therapies to induce cancer cell death (apoptosis). -0-

-- Positron emission tomography (PET) measurement of death receptor 5

    (DR5) receptor occupancy (RO) using (64)Cu-labeled AMG 655 in

    colo205 xenografts.

   Overview: Researchers evaluated the potential for PET to measure

    DR5 RO non-invasively using (64)Cu-labeled AMG 655 in an AMG 655-

    sensitive xenograft model (Colo205).

   Abstract No. 3162 (Monday, April 14, 2008, 1:00 PM - 5:00 PM)


-- AMG 655, a monoclonal antibody agonist directed against Death

    Receptor 5, induces apoptosis in human colon carcinoma cell lines

    and its therapeutic potential is enhanced in combination with

    chemotherapeutic agents.

   Overview: Researchers evaluated the anti-tumor potential of AMG 655

    when it is combined with irinotecan or 5-flurouracil in a colon

    cancer model.

   Abstract No. 1326 (Sunday, April 13, 2008, 1:00 PM - 5:00 PM)


-- AMG 655, a fully human agonistic antibody against Death Receptor 5,

    enhances the anti-tumor activity of gemcitabine in MiaPaCa2/T2, a

    pancreatic cancer model.

   Overview: Researchers evaluated the anti-tumor potential of AMG 655

    when it is added to gemcitabine in a pancreatic cancer model.

   Abstract No. 3999 (Tuesday, April 15, 2008, 8:00 AM - 12:00 PM)

Growth Regulation

A program focused on targeting cellular pathways that regulate cell pre-production, survival, migration and invasion which cancer cells often escape. -0-

-- Exploratory biomarkers in the HGF/SF: c-Met axis: preclinical and

    clinical results.

   Overview: Examination of exploratory biomarkers that may help

    determine treatment response in several types of cancers.

   Abstract No. 2804 (Monday, April 14, 2008, 1:00 PM - 5:00 PM)


-- AMG 479, a fully human anti-IGF-1R monoclonal antibody, inhibits

    IGF-1 induced phospho-Akt and enhances the antineoplastic activity

    of cyclophosphamide in vivo

   Overview: Examining pathway activation in ongoing Ewing's sarcoma

    trial.

   Abstract No. 4001 (Tuesday, April 15, 2008, 8:00 AM - 12:00 PM)


-- Domain-specific mechanisms of receptor inhibition by AMG 479, a

    fully-human IGF1R targeted antibody

   Overview: Inhibition of tumor growth with AMG 479 and other L2

    domain antibodies versus CR and FnIII-1 antibodies in vivo using

    two different tumor models.

   Abstract No. 3994 (Tuesday, April 15, 2008, 8:00 AM - 12:00 PM)

About Amgen

Amgen discovers, develops, manufactures and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives. To learn more about our pioneering science and our vital medicines, visit www.amgen.com.

Forward-Looking Statements

This news release contains forward-looking statements that are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and assumptions that could cause actual results to differ materially from those described. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission (SEC) reports filed by Amgen, including Amgen's most recent annual report on Form 10-K and most recent periodic reports on Form 10-Q and Form 8-K. Please refer to Amgen's most recent Forms 10-K, 10-Q and 8-K for additional information on the uncertainties and risk factors related to our business. Unless otherwise noted, Amgen is providing this information as of April 3, 2008 and expressly disclaims any duty to update information contained in this news release.

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Contact

Amgen, Thousand Oaks
Christine Regan, 805-447-5476 (media)
Arvind Sood, 805-447-1060 (investors)

Posted: April 2008

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