Acute Lymphocytic Leukemia: Impressive Results With the Monoclonal Antibody Blinatumomab in Patients With Refractory Disease
AMSTERDAM, June 15, 2012/PRNewswire/ --At the 17th Congress of the European Hematology Association in Amsterdam Professor Max Topp of the University of Wuerzberg in Germany presents the impressive results with a bispecific antibody for Acute Lymphoblastic Leukemia patients.
The Phase 2 dose-ranging study MT103-206 evaluated the efficacy,
safety and tolerability of blinatumomab in adult patients with
B-precursor Acute Lymphoblastic Leukemia who had relapsed following
treatment with standard front-line chemotherapy or allogeneic stem
cell transplant. Patients received blinatumomab for 28 days
followed by two weeks off therapy over a six week treatment cycle,
for up to five treatment cycles. Patients received a continuous
intravenous infusion of blinatumomab at an initial dose of five or
15 micrograms/m2 per day, escalating to 30 micrograms for the
remainder of the treatment. The primary endpoint of the study was
the rate of complete remission (CR) and complete remission with
partial hematologic recovery (CRh*). Secondary endpoints included
molecular response rate, duration of response and overall survival.
All 36 patients were evaluable for efficacy and safety.
Twenty-six of the 36 patients (72%) treated with blinatumomab
across all of the tested doses and schedules achieved a CR/CRh*.
All but two patients achieved a molecular response, meaning there
was no evidence of leukemic cells by polymerase chain reaction. The
most common adverse events were pyrexia, headache and tremor.
Medically important safety events were reversible cytokine release
syndrome and CNS adverse events.
At the time of the analysis, median survival was 9.0 (8.2, 15.8)
months with a median follow-up period of 10.7 months. The median
duration of response in the 26 patients who responded to treatment
was 8.9 months.
About the EHA Annual Congress
After 16 congresses and constantly increasing number of delegates,
the 17th Congress of EHA is taking place in Amsterdam. Hematology
is a specialty that covers everything to do with blood: its origin
in the bone marrow, diseases (in the production) of blood and their
treatments. The latest data on research and developments within the
wide spectrum of hematology are presented.
Source: European Hematology Association
Contact: EHA Executive Office, Ineke van der Beek, Jon Tarifa,
E-mail: press@ehaweb.org , Mobile: +31(0)6
2011-1055
Posted: June 2012
