Zyban sustained-release tabletsPronunciation
Generic Name: bupropion (bue-PROE-pee-on)
Brand Name: Zyban
Although Zyban sustained-release tablets are not used to treat depression, it contains the same ingredient that is in Wellbutrin, an antidepressant. Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Zyban sustained-release tablets outweigh the risks.
Some patients have also developed depression and certain other mental or mood problems, including suicidal thoughts or actions, while taking Zyban sustained-release tablets to help them quit smoking. Family and caregivers must closely watch patients who take Zyban sustained-release tablets. It is important to keep in close contact with the doctor. Contact the doctor at once if new, worsened, or sudden symptoms such as agitation, hostility, depressed mood, or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur. Discuss any questions with the doctor.
Zyban sustained-release tablets are used for:
Helping certain patients to stop smoking. It may also be used for other conditions as determined by your doctor.
Zyban sustained-release tablets are an antidepressant that has been shown to help certain people stop smoking. Exactly how Zyban sustained-release tablets works is not known.
Do NOT use Zyban sustained-release tablets if:
- you are allergic to any ingredient in Zyban sustained-release tablets
- you are taking any other medicine that contains bupropion
- you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy)
- you are suddenly stopping the use of alcohol, benzodiazepines (eg, alprazolam), sedatives (medicines that make you sleepy), or seizure medicines (eg, phenobarbital) after long-term use
- you are taking or have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using Zyban sustained-release tablets:
Some medical conditions may interact with Zyban sustained-release tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, or alcohol or substance abuse
- if you have diabetes, kidney problems, liver problems (eg, cirrhosis), high blood pressure, heart problems (eg, congestive heart failure), or increased eye pressure or glaucoma, or have had a recent heart attack
- if you have a history of seizures, a head injury, or a tumor in the brain or spinal cord
- if you are taking nonprescription weight loss medicines or stimulants
- if you are taking a medicine that contains methylene blue
Some MEDICINES MAY INTERACT with Zyban sustained-release tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Amantadine, other antidepressants (eg, amitriptyline, fluvoxamine), antipsychotics (eg, haloperidol, risperidone), clopidogrel, corticosteroids (eg, prednisone), cyclophosphamide, HIV protease inhibitors (eg, nelfinavir), insulin, levodopa, linezolid , MAOIs (eg, phenelzine), nicotine patches, oral hypoglycemics (eg, glipizide), orphenadrine, sympathomimetics (eg, pseudoephedrine), theophylline, thiotepa, tiagabine, or ticlopidine because they may increase the risk of Zyban sustained-release tablets's side effects
- Carbamazepine, efavirenz, phenobarbital, phenytoin, rifampin, or ritonavir because they may decrease Zyban sustained-release tablets's effectiveness
- Antiarrhythmics (eg, flecainide, propafenone), beta-blockers (eg, metoprolol), phenothiazines (eg, thioridazine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or tricyclic antidepressants (eg, nortriptyline) because the risk of their side effects may be increased by Zyban sustained-release tablets
- Tamoxifen because its effectiveness may be decreased by Zyban sustained-release tablets, which may lead to an increased risk of breast cancer recurrence in women with a history of breast cancer
This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyban sustained-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Zyban sustained-release tablets:
Use Zyban sustained-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Zyban sustained-release tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zyban sustained-release tablets refilled.
- Take Zyban sustained-release tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Swallow Zyban sustained-release tablets whole. Do not break, crush, divide, or chew before swallowing.
- Several weeks may pass before your symptoms improve. Do not stop taking Zyban sustained-release tablets without checking with your doctor.
- Take your doses at the same times each day, at least 8 hours apart unless directed otherwise by your doctor. This may help to decrease the risk of seizures with Zyban sustained-release tablets.
- It takes about 1 week for Zyban sustained-release tablets to work. You should begin taking Zyban sustained-release tablets while you are still smoking. However, you and your doctor should decide on a date that you will stop smoking during the 2nd week of taking Zyban sustained-release tablets.
- If you have not made progress towards stopping smoking by the 12th week, contact your doctor.
- If you are not able to stop smoking while using Zyban sustained-release tablets, talk to your doctor to determine why you were not successful. After the reasons have been reduced or eliminated, you should try to stop smoking again.
- Continue to take Zyban sustained-release tablets even if you feel well. Do not miss any doses.
- If you miss a dose of Zyban sustained-release tablets, skip the missed dose and go back to your regular dosing schedule. Do not take more than 1 dose within 8 hours. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Zyban sustained-release tablets.
Important safety information:
- Zyban sustained-release tablets may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zyban sustained-release tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Zyban sustained-release tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Zyban sustained-release tablets may increase your risk of seizures. Your risk may be greater if you also have certain medical conditions, use certain medicines, or if you use a lot of alcohol. Talk to your doctor to see if you may have a greater risk of seizures while taking Zyban sustained-release tablets.
- If you already drink alcohol or use sedatives, do not suddenly stop them without first checking with your doctor. Suddenly stopping them may increase your seizure risk.
- Do not take decongestants (eg, pseudoephedrine), stimulants, or diet pills while you are taking Zyban sustained-release tablets without first checking with your doctor. They may increase your risk of seizures.
- The risk of seizures may be greater if you take Zyban sustained-release tablets in high doses or for a long time. Do NOT take more than the recommended dose, change your dose, or use Zyban sustained-release tablets for longer than prescribed without checking with your doctor.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) has happened with Zyban sustained-release tablets. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- Some people may be at risk for eye problems from Zyban sustained-release tablets. Your doctor may want you to have an eye exam to see if you are at risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, or swelling or redness in or around the eye.
- If you have trouble sleeping, you may be taking your dose too close to bedtime. Talk with your doctor about changing your dosing schedule.
- It is important to follow the program that your doctor has prescribed, including behavioral changes, counseling, or support services, in order to stop smoking.
- Zyban sustained-release tablets can be used together with the nicotine skin patches only under the supervision of your doctor. Using these medicines together may raise your blood pressure. If you are already using a nicotine skin patch, your blood pressure should be checked regularly.
- Do not smoke if you are using Zyban sustained-release tablets along with the nicotine skin patch or any nicotine product.
- Stopping smoking may change the amount of certain medicines (eg, theophylline, warfarin) in your blood. Be sure your doctor knows all the medicines that you are taking.
- Zyban sustained-release tablets contains the same ingredients as the antidepressants Aplenzin and Wellbutrin. Do not take Zyban sustained-release tablets if you are also taking Aplenzin, Wellbutrin, or other brands of bupropion. Discuss any questions or concerns with your doctor.
- Zyban sustained-release tablets may interfere with certain lab tests, including urine screenings for amphetamines. Be sure your doctor and lab personnel know you are taking Zyban sustained-release tablets.
- Use Zyban sustained-release tablets with caution in the ELDERLY; they may be more sensitive to its effects.
- Zyban sustained-release tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyban sustained-release tablets while you are pregnant. Zyban sustained-release tablets are found in breast milk. If you are or will be breast-feeding while you use Zyban sustained-release tablets, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Zyban sustained-release tablets:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Anxiety; changes in appetite; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; nausea; nervousness; stomach pain; stuffy nose; trouble sleeping; vomiting; weight changes.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; changes in sexual desire or ability; confusion; dark urine; delusions; fainting; fast or irregular heartbeat; fever or chills; hallucinations; hearing problems or ringing in the ears; joint or muscle pain; menstrual changes; new or worsening mental or mood changes (eg, concentration problems, depression, panic attacks, aggressiveness, agitation, anxiety, impulsiveness, irritability, hostility, exaggerated feeling of well-being, inability to sit still); pale stools; red, swollen, blistered, or peeling skin; seizures; severe headache or dizziness; severe or persistent nausea, vomiting, or stomach pain; severe or persistent restlessness or trouble sleeping; shortness of breath; suicidal thoughts or attempts; tremor; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Zyban sustained-release tablets:
Store Zyban sustained-release tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zyban sustained-release tablets out of the reach of children and away from pets.
- If you have any questions about Zyban sustained-release tablets, please talk with your doctor, pharmacist, or other health care provider.
- Zyban sustained-release tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Zyban sustained-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zyban sustained-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zyban sustained-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Zyban sustained-release tablets.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.