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Zuplenz soluble film

Generic Name: ondansetron (on-DAN-se-tron)
Brand Name: Zuplenz

Zuplenz soluble film is used for:

Preventing nausea and vomiting associated with chemotherapy, radiation treatment, or surgery. It may also be used for other conditions as determined by your doctor.

Zuplenz soluble film is a serotonin 5-HT3 receptor blocker. It works by blocking a chemical thought to be a cause of nausea and vomiting in certain situations (eg, chemotherapy).

Do NOT use Zuplenz soluble film if:

  • you are allergic to any ingredient in Zuplenz soluble film
  • you have a certain type of irregular heartbeat (congenital long QT syndrome)
  • you are taking apomorphine, arsenic, dronedarone, halofantrine, nilotinib, toremifene, or vandetanib

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Zuplenz soluble film:

Some medical conditions may interact with Zuplenz soluble film. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had an allergic reaction to another serotonin 5-HT3 receptor blocker (eg, dolasetron, granisetron)
  • if you have liver problems, heart problems (eg, congestive heart failure, slow or irregular heartbeat), or electrolyte problems (eg, low potassium or magnesium levels)
  • if a member of your family has a history of congenital long QT syndrome
  • if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Zuplenz soluble film. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, amiodarone, dofetilide, dronedarone), arsenic, asenapine, bepridil, chloroquine, cisapride, citalopram, clozapine, crizotinib, dasatinib, diuretics (eg, furosemide, hydrochlorothiazide), dolasetron, domperidone, doxepin, droperidol, halofantrine, haloperidol, lapatinib, macrolide antibiotics (eg, clarithromycin, erythromycin), maprotiline, methadone, nilotinib, nortriptyline, paliperidone, pentamidine, phenothiazines (eg, chlorpromazine, thioridazine), pimozide, quetiapine, quinolone antibiotics (eg, levofloxacin), sunitinib, tacrolimus, telithromycin, tetrabenazine, toremifene, vandetanib, vemurafenib, or ziprasidone because the risk of serious and sometimes fatal irregular heartbeat (prolonged QT interval) may be increased
  • Apomorphine because the risk of its side effects may be increased by Zuplenz soluble film

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zuplenz soluble film may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zuplenz soluble film:

Use Zuplenz soluble film as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Zuplenz soluble film. Talk to your pharmacist if you have questions about this information.
  • Do not remove the film strip from the foil pouch until you are ready to take Zuplenz soluble film. Use the film strip immediately after opening the pouch. Do not store the removed film strip for future use.
  • Make sure that your hands are dry when you open the foil pouch.
  • To use Zuplenz soluble film, fold the pouch along the dotted line and tear it along the edge. Remove the film strip and place it on the top of your tongue. Once the strip dissolves, it can be swallowed with saliva. Zuplenz soluble film may be taken with or without liquid.
  • Do not chew or swallow Zuplenz soluble film whole.
  • Wash your hands after you use Zuplenz soluble film.
  • It is important to take Zuplenz soluble film as directed to prevent nausea and vomiting. If you forget to take a dose of Zuplenz soluble film, take it when you remember as directed by your doctor. If you are not sure what to do, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Zuplenz soluble film.

Important safety information:

  • Zuplenz soluble film may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zuplenz soluble film with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Zuplenz soluble film should be used with extreme caution in CHILDREN younger than 4 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zuplenz soluble film while you are pregnant. It is not known if Zuplenz soluble film is found in breast milk. If you are or will be breast-feeding while you use Zuplenz soluble film, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zuplenz soluble film:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; drowsiness; headache; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; wheezing; unusual hoarseness); chest pain; dizziness or light-headedness; fainting; fast, slow, or irregular heartbeat; fever; seizures; skin tingling or numbness; stomach pain; trouble urinating; uncontrollable or involuntary muscle movements; vision changes (including sudden temporary blindness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe constipation; severe dizziness; slow or irregular heartbeat; sudden, temporary blindness.

Proper storage of Zuplenz soluble film:

Store Zuplenz soluble film at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep the foil pouches in the carton. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zuplenz soluble film out of the reach of children and away from pets.

General information:

  • If you have any questions about Zuplenz soluble film, please talk with your doctor, pharmacist, or other health care provider.
  • Zuplenz soluble film is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Zuplenz soluble film or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zuplenz soluble film. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zuplenz soluble film. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Zuplenz soluble film.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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