Generic Name: zonisamide (zoe-NIS-a-mide)
Brand Name: Zonegran
Zonegran is used for:
Treating certain types of seizures (partial seizures) in patients with epilepsy. It is used along with other medicines. It may also be used for other conditions as determined by your doctor.
Zonegran is an anticonvulsant. Exactly how Zonegran works is not known.
Do NOT use Zonegran if:
- you are allergic to any ingredient in Zonegran or to a sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, or valdecoxib
- you have kidney failure
Contact your doctor or health care provider right away if any of these apply to you.
Before using Zonegran:
Some medical conditions may interact with Zonegran. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances (including tartrazine)
- if you are allergic to aspirin
- if you have a history of status epilepticus (eg, long periods of continuous seizure activity or a series of seizures without a full return to consciousness)
- if you have a history of liver or kidney problems, kidney stones, lung or breathing problems, mental or mood problems (eg, depression), or suicidal thoughts or actions
- if you have a skin rash
- if you have diarrhea, will be having surgery, or are on a ketogenic diet
Some MEDICINES MAY INTERACT with Zonegran. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticholinergics (eg, benztropine) or carbonic anhydrase inhibitors (eg, acetazolamide) because the risk of heatstroke or high blood acid levels may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Zonegran may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Zonegran:
Use Zonegran as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Zonegran comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zonegran refilled.
- Take Zonegran by mouth with or without food.
- Swallow Zonegran whole. Do not break, crush, or chew before swallowing.
- Drink plenty of liquids (6 to 8 glasses of water per day) while taking Zonegran to help prevent kidney stones.
- Do not suddenly stop taking Zonegran. Suddenly stopping Zonegran may cause seizures to occur more often. If you need to stop Zonegran, your doctor will gradually lower your dose.
- If you miss a dose of Zonegran, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Zonegran.
Important safety information:
- Zonegran may cause dizziness, drowsiness, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use Zonegran with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Zonegran may reduce sweating, which could increase the risk of heat stroke, especially in children. The risk is greater in hot weather and/or during vigorous exercise. Drink plenty of fluids. Dress lightly while in hot climates or when exercising. Check carefully for signs of decreased sweating. If this occurs, promptly seek cooler or air-conditioned shelter and/or stop exercising. Seek medical attention right away if you have an unexplained fever, mental or mood changes, headache, or dizziness.
- Zonegran may cause high blood acid levels (metabolic acidosis). The risk may be greater in children and in patients with kidney problems, status epilepticus, severe breathing problems, or diarrhea. It may also be greater in patients who are taking certain other medicines (eg, acetazolamide), will be having surgery, or are on a ketogenic diet. Over a period of time, metabolic acidosis may cause kidney problems, bone problems, or decreased growth in children. Contact your doctor immediately if you experience fast breathing, unusual weakness or fatigue, sluggishness, fainting, persistent loss of appetite, or irregular heartbeat.
- Patients who take Zonegran may be at increased risk of suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Zonegran closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
- Contact your doctor right away if your seizures worsen or if you develop a skin rash.
- Tell your doctor or dentist that you take Zonegran before you receive any medical or dental care, emergency care, or surgery.
- Carry an ID card at all times that says you take Zonegran.
- This product may contain tartrazine dye (FD&C Yellow No. 5). This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.
- Women who take Zonegran should use effective birth control while using Zonegran.
- Lab tests, including kidney function or blood bicarbonate levels, may be performed while you use Zonegran. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Zonegran with caution in the ELDERLY; they may be more sensitive to its effects.
- Zonegran should be used with extreme caution in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed. CHILDREN may be at a higher risk of heatstroke, kidney stones, decreased growth, and metabolic acidosis.
- PREGNANCY AND BREAST-FEEDING: Zonegran may cause harm to the fetus. Do not become pregnant while you are using it. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zonegran while you are pregnant. It is not known if Zonegran is found in breast milk. If you are or will be breast-feeding while you use Zonegran, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Zonegran:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Abnormal skin sensations; diarrhea; dizziness; drowsiness; flu-like symptoms; headache; irritability; loss of appetite; nausea; stomach upset; tiredness; trouble sleeping; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bone pain; change in the amount of urine produced; confusion; dark or bloody urine; decreased sweating; double vision or other vision problems; fainting; fast breathing; fast, slow, or irregular heartbeat; fever, chills, cough, or sore throat; loss of coordination; memory problems; mouth sores; new or worsening mental or mood changes (eg, depression, agitation, anxiety, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, inability to sit still); new or worsening seizures; painful urination; persistent loss of appetite; red, swollen, blistered, or peeling skin; severe muscle pain or weakness; severe or persistent drowsiness; sluggishness; sudden stomach or back pain; suicidal thoughts or actions; swelling of the hands, ankles, or feet; tremor; trouble speaking or other speech problems; trouble thinking or concentrating; unusual bruising or bleeding; unusual eye movements; unusual or disturbing thoughts; unusual tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include difficult, slow, or shallow breathing; severe or persistent dizziness; slow heartbeat; weakness.Proper storage of Zonegran:
Store Zonegran at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zonegran out of the reach of children and away from pets.
- If you have any questions about Zonegran, please talk with your doctor, pharmacist, or other health care provider.
- Zonegran is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Zonegran or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zonegran. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zonegran. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Zonegran.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.