Voraxaze

Generic Name: glucarpidase (gloo-KAR-pid-ase)
Brand Name: Voraxaze

Voraxaze is used for:

Treating dangerously high blood methotrexate levels in certain patients.

Voraxaze is a carboxypeptidase. It works by converting methotrexate to an inactive substance.

Do NOT use Voraxaze if:

  • you are allergic to any ingredient in Voraxaze

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Voraxaze:

Some medical conditions may interact with Voraxaze. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have normal kidney function

Some MEDICINES MAY INTERACT with Voraxaze. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Folates or similar medicines because their effectiveness may decreased by Voraxaze

This may not be a complete list of all interactions that may occur. Ask your health care provider if Voraxaze may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Voraxaze:

Use Voraxaze as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Voraxaze is usually given as an injection at your doctor's office, hospital, or clinic.
  • If you are taking leucovorin, do not take it within 2 hours before or 2 hours after receiving Voraxaze.
  • Do not use Voraxaze if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Voraxaze, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Voraxaze.

Important safety information:

  • Rarely, an infusion reaction may occur with Voraxaze. Tell your doctor right away if you develop fever, chills, flushing, feeling hot, rash, hives, itching, throat tightness or breathing problems, tingling, numbness, or headache.
  • Lab tests, including kidney function and blood methotrexate levels, may be performed while you use Voraxaze and after you receive it. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: It is not known if Voraxaze can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Voraxaze while you are pregnant. It is not known if Voraxaze is found in breast milk. If you are or will be breast-feeding while you use Voraxaze, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Voraxaze:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue); blurred vision; burning, numbness, or tingling; chills; fainting; fever; flushing of the skin; severe dizziness, drowsiness, or light-headedness; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Voraxaze:

Voraxaze is usually handled and stored by a health care provider. Keep Voraxaze out of the reach of children and away from pets.

General information:

  • If you have any questions about Voraxaze, please talk with your doctor, pharmacist, or other health care provider.
  • Voraxaze is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Voraxaze or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Voraxaze. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Voraxaze. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Voraxaze.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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