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Vismodegib

Generic Name: vismodegib (VIS-moe-DEG-ib)
Brand Name: Erivedge

Vismodegib may cause serious birth defects and/or fetal death if taken during pregnancy. Women who either take vismodegib or are sexual partners of men who take vismodegib must have a negative pregnancy test within 7 days before therapy with vismodegib is started. Women who take vismodegib must use effective birth control while taking it and for 7 months after vismodegib is stopped. Men who take vismodegib must use condoms with spermicide as birth control while taking it and for 2 months after vismodegib is stopped. If you think you or your sexual partner may be pregnant, contact your doctor right away.


Vismodegib is used for:

Certain types of skin cancer in certain patients. It may also be used for other conditions as determined by your doctor.

Vismodegib is a hedgehog signaling pathway inhibitor. It works by blocking certain substances in the body, which kills certain cancer cells.

Do NOT use vismodegib if:

  • you are allergic to any ingredient in vismodegib

Contact your doctor or health care provider right away if any of these apply to you.

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Before using vismodegib:

Some medical conditions may interact with vismodegib. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are able to become pregnant or father a child

Some MEDICINES MAY INTERACT with vismodegib. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Azithromycin, clarithromycin, or erythromycin because they may increase the risk of vismodegib's side effects
  • Antacids, H2-receptor blockers (eg, famotidine), or proton pump inhibitors (PPIs) (eg, omeprazole) because they may decrease vismodegib's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if vismodegib may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use vismodegib:

Use vismodegib as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Vismodegib comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get vismodegib refilled.
  • Take vismodegib by mouth with or without food.
  • Swallow vismodegib whole. Do not open, break, crush, or chew before swallowing.
  • If you miss a dose of vismodegib, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use vismodegib.

Important safety information:

  • Women who take vismodegib must use effective birth control while taking it and for 7 months after vismodegib is stopped. Talk with your doctor about what birth control method is best for you.
  • Men who take vismodegib, even those who have had a vasectomy, must use condoms with spermicide as birth control while taking it and for 2 months after vismodegib is stopped.
  • Women who either take vismodegib or are sexual partners of men who take vismodegib must have a pregnancy test within 7 days before therapy with vismodegib is started.
  • Talk with your doctor right away if you have unprotected sex or if you think that your birth control has failed.
  • Do not donate blood or blood products while you take vismodegib and for at least 7 months after your last dose of vismodegib to prevent exposure through a blood transfusion to a pregnant woman.
  • Vismodegib should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Vismodegib may cause serious birth defects and/or fetal death if taken during pregnancy. Do not become pregnant while you are using it. If you think you or your sexual partner may be pregnant while you are taking vismodegib or during the 7 months after your last dose of vismodegib, contact your doctor right away. It is not known if vismodegib is found in breast milk. Do not breast-feed while taking vismodegib.

Possible side effects of vismodegib:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; hair loss; joint pain; loss of appetite; loss of taste or other taste changes; muscle spasms; nausea; tiredness; vomiting; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); absent menstrual period; decreased urination; symptoms of low blood potassium levels (eg, muscle pain, weakness, or cramping; irregular heartbeat); symptoms of low blood sodium levels (eg, confusion, mental or mood changes, seizures, sluggishness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of vismodegib:

Store vismodegib at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep vismodegib out of the reach of children and away from pets.

General information:

  • If you have any questions about vismodegib, please talk with your doctor, pharmacist, or other health care provider.
  • Vismodegib is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take vismodegib or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about vismodegib. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to vismodegib. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using vismodegib.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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