Generic Name: lapatinib (la-PA-ti-nib)
Brand Name: Tykerb
Severe and sometimes fatal liver problems may occur with the use of Tykerb. These problems may develop within days or several months after you start using it. Tell your doctor if you have a history of liver problems. Your doctor may need to check your liver function before you start Tykerb and while you are taking it. Be sure to keep all doctor and lab appointments. Contact your doctor right away if you develop dark urine, pale stools, severe stomach pain, severe tiredness or weakness, unusual itching, or yellowing of the eyes or skin.
Tykerb is used for:
Treating certain types of advanced or metastatic breast cancer. It is used in combination with another medicine (capecitabine or letrozole). It may also be used for other conditions as determined by your doctor.
Tykerb is a protein-tyrosine kinase inhibitor. It works by preventing the growth of cancer cells.
Do NOT use Tykerb if:
- you are allergic to any ingredient in Tykerb
- you have developed liver problems from taking Tykerb in the past
- you have uncorrected low blood potassium or magnesium levels
Contact your doctor or health care provider right away if any of these apply to you.
Before using Tykerb:
Some medical conditions may interact with Tykerb. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have bone marrow problems, low white blood cell counts, or low blood platelets
- if you have a history of liver problems, lung problems, heart problems (eg, heart failure), or an irregular heartbeat (eg, QT prolongation)
- if you have low blood potassium or magnesium levels
- if you are taking a calcium channel blocker (eg, diltiazem, verapamil, nifedipine) or you take medicine for depression or stomach problems (eg, ulcers, heartburn, reflux)
- if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat
- if you have received an anthracycline (eg, doxorubicin) in the past
Some MEDICINES MAY INTERACT with Tykerb. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Antiarrhythmics (eg, amiodarone, quinidine), arsenic, astemizole, bepridil, chloroquine, cisapride, dofetilide, dolasetron, domperidone, droperidol, halofantrine, haloperidol, iloperidone, ketolides (eg, telithromycin), macrolide antibiotics (eg, erythromycin), maprotiline, methadone, paliperidone, pentamidine, phenothiazines (eg, thioridazine), pimozide, quinolone antibiotics (eg, ciprofloxacin), romidepsin, tacrolimus, terfenadine, toremifene, certain tricyclic antidepressants (eg, doxepin, nortriptyline), vandetanib, or ziprasidone because the risk of a certain type of irregular heartbeat (QT prolongation) may be increased
- Atazanavir, azole antifungals (eg, itraconazole, ketoconazole, posaconazole), nefazodone, protease inhibitors (eg, boceprevir, indinavir, ritonavir), or voriconazole because they may increase the risk of Tykerb's side effects
- Carbamazepine, dexamethasone, hydantoins (eg, phenytoin), nevirapine, phenobarbital, primidone, rifamycins (eg, rifampin) or St. John's wort because they may decrease Tykerb's effectiveness
- Digoxin, midazolam, or paclitaxel because the risk of their side effects may be increased by Tykerb
This may not be a complete list of all interactions that may occur. Ask your health care provider if Tykerb may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Tykerb:
Use Tykerb as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Tykerb. Talk to your pharmacist if you have questions about this information.
- Take Tykerb by mouth at least 1 hour before or 1 hour after eating.
- Do not eat grapefruit or drink grapefruit juice while you use Tykerb.
- If you miss a dose of Tykerb, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Tykerb.
Important safety information:
- Tell your doctor or dentist that you take Tykerb before you receive any medical or dental care, emergency care, or surgery.
- Diarrhea is a common side effect of Tykerb. If you get diarrhea, call your doctor right away for instructions on how to treat it. Do not treat diarrhea without first checking with your doctor. Severe or persistent diarrhea can cause you to become dehydrated and can sometimes be deadly. Talk with your doctor for more information.
- A severe skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have symptoms like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- If you may become pregnant, you must use an effective form of birth control while you take Tykerb. If you have questions about effective birth control, talk with your doctor.
- Lab tests, including liver function, heart function, and complete blood cell counts, may be performed while you use Tykerb. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- PREGNANCY and BREAST-FEEDING: Tykerb may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tykerb while you are pregnant. It is not known if Tykerb is found in breast milk. Do not breast-feed while taking Tykerb.
Possible side effects of Tykerb:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Back pain; diarrhea; dry skin; fingernail or toenail changes; headache; indigestion; loss of appetite; mild hair loss or thinning; mouth sores; nausea; nosebleed; redness and tingling of the hands and feet; tiredness; trouble sleeping; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; dizziness or light-headedness; fast or irregular heartbeat; pale stools; persistent loss of appetite; severe or persistent cough; severe or persistent diarrhea, nausea, vomiting, or stomach cramping or pain; severe pain, redness, or swelling of the hands or feet; severe tiredness or weakness; shortness of breath; unusual bruising or bleeding; unusual itching; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Tykerb:
Store Tykerb between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tykerb out of the reach of children and away from pets.
- If you have any questions about Tykerb, please talk with your doctor, pharmacist, or other health care provider.
- Tykerb is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Tykerb or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Tykerb. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Tykerb. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Tykerb.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.