Trasylol

Generic Name: aprotinin (a-proe-TYE-nin)
Brand Name: Trasylol

Trasylol may cause severe and sometimes fatal allergic reactions (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; fast heartbeat; pale skin; severe low blood pressure; loss of consciousness possibly leading to a lack of heartbeat or breathing). The risk is increased in patients who have previously received Trasylol. The risk of fatal allergic reactions may be greater in patients who receive Trasylol more than once in a 12-month period of time. Tell your doctor if you think you have ever had Trasylol in the past.


Trasylol is used for:

Reducing blood loss and the need for blood transfusions in patients undergoing certain types of heart surgery.

Trasylol is a protease inhibitor. It works by reducing the inflammatory response associated with cardiopulmonary bypass surgery.

Do NOT use Trasylol if:

  • you are allergic to any ingredient in Trasylol
  • you have received Trasylol within the past 12 months

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Trasylol:

Some medical conditions may interact with Trasylol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems
  • if you have previously had heart surgery

Some MEDICINES MAY INTERACT with Trasylol. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aminoglycosides (eg, gentamicin) or medicines that alter kidney function because the risk of kidney damage may be increased
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril) or fibrinolytics (eg, streptokinase) because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trasylol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trasylol:

Use Trasylol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Trasylol. Talk to your pharmacist if you have questions about this information.
  • Trasylol is administered as an intravenous (IV; into a vein) injection only in a medical setting.
  • If you miss a dose of Trasylol, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Trasylol.

Important safety information:

  • Lab tests, including kidney function and blood clotting tests, may be performed while you use Trasylol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Trasylol should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Trasylol while you are pregnant. It is not known if Trasylol is found in breast milk. If you are or will be breast-feeding while you use Trasylol, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Trasylol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; difficulty urinating; infection (eg, fever, chills, sore throat); lightheadedness; sleeplessness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); asthma; chest pain; confusion; decreased urination; fast or irregular heartbeat; lung disorder; nausea; numbness of an arm or leg; one-sided weakness; severe stomach pain; sudden severe headache, dizziness, fainting, or vomiting; sudden weight gain; swelling of the hands, legs, or feet; vision or speech changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800 -222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Trasylol:

Trasylol is usually handled and stored by a health care provider. Keep Trasylol out of the reach of children and away from pets.

General information:

  • If you have any questions about Trasylol, please talk with your doctor, pharmacist, or other health care provider.
  • Trasylol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Trasylol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Trasylol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Trasylol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Trasylol.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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