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Tiopronin

Generic Name: tiopronin (tye-oh-PRO-nin)
Brand Name: Thiola

Tiopronin is used for:

Preventing kidney stone formation in certain patients.

Tiopronin is a chelating agent. It works by removing extra cystine (the cause of kidney stones) from the urine, which keeps the kidney stones from forming.

Do NOT use tiopronin if:

  • you are allergic to any ingredient in tiopronin
  • you are breast-feeding
  • you have a history of anemia, low white blood cell counts, or low platelet counts resulting from the use of tiopronin

Contact your doctor or health care provider right away if any of these apply to you.

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Before using tiopronin:

Some medical conditions may interact with tiopronin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant or planning to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have anemia, bleeding in the lungs, low white blood cell counts, low platelet counts, or muscle weakness

Some MEDICINES MAY INTERACT with tiopronin. However, no specific interactions with tiopronin are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if tiopronin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use tiopronin:

Use tiopronin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take tiopronin on an empty stomach at least 1 hour before or 2 hours after eating.
  • Drink at least ten 10-ounce glasses of water each day, including 2 glasses with each meal and at bedtime. You will probably wake up at night to urinate, and you should drink 2 more glasses before returning to bed. Drink extra fluids if you have excessive sweating or urination.
  • When you first start taking tiopronin, it may cause an increase in urine or in frequency of urination. To prevent this from affecting sleep, try not to take any dose later than 6 pm.
  • If you miss a dose of tiopronin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use tiopronin.

Important safety information:

  • Tiopronin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Be sure to follow the diet and exercise program prescribed by your health care provider.
  • LAB TESTS, including blood cell counts and liver function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Tiopronin is not recommended for use in CHILDREN younger than 9 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Tiopronin may cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using tiopronin during pregnancy. Tiopronin is excreted in breast milk. Do not breast-feed while taking tiopronin.

Possible side effects of tiopronin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; changes in taste; diarrhea; drying of skin; gas; loss of appetite; nausea; soft stools; stomach bloating; stomach pain; vomiting; wrinkling or crumbling of skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever; joint pain; muscle weakness; red rash with fever; sore throat; unusual bleeding or bruising; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of tiopronin:

Store tiopronin at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep tiopronin out of the reach of children and away from pets.

General information:

  • If you have any questions about tiopronin, please talk with your doctor, pharmacist, or other health care provider.
  • Tiopronin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take tiopronin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about tiopronin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to tiopronin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using tiopronin.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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