Generic Name: trimethobenzamide (trye-METH-oh-BENZ-a-mide)
Brand Name: Tigan

Tigan is used for:

Treating nausea and vomiting.

Tigan is an antiemetic. It works by blocking one of the chemical messengers that stimulates nausea and vomiting.

Do NOT use Tigan if:

  • you are allergic to any ingredient in Tigan
  • you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Tigan:

Some medical conditions may interact with Tigan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a brain disease (eg, encephalitis), dehydration, electrolyte disturbance, fever, persistent diarrhea, or Reye syndrome
  • if you have a history of kidney problems

Some MEDICINES MAY INTERACT with Tigan. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Ethanol (alcohol-containing beverages or medicines) because side effects, such as increased drowsiness, may occur
  • Sodium oxybate (GHB) because side effects, such as drowsiness and increased sleep duration, may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tigan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tigan:

Use Tigan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Tigan by mouth on an empty stomach at least 1 hour before or 2 hours after eating, unless instructed otherwise by your doctor.
  • If you miss a dose of Tigan and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tigan.

Important safety information:

  • Tigan may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Tigan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Tigan; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • If your symptoms do not get better within a few days or if they get worse, check with your doctor.
  • Do not use Tigan for future conditions without checking with your doctor.
  • Use Tigan with caution in the ELDERLY; they may be more sensitive to its effects.
  • Do not give CHILDREN Tigan to treat vomiting when the cause of vomiting is unknown. Tigan may contribute to the development of Reye syndrome, a rare but serious illness.
  • PREGNANCY and BREAST-FEEDING: It is not known if Tigan is found in breast milk. If you are or will be breast-feeding while you use Tigan, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Tigan:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; depression; diarrhea; disorientation; dizziness; drowsiness; headache; muscle cramps.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); convulsions; fever; loss of balance; seizures; shuffling walk; sore throat; uncontrolled movements of the arms or legs; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Tigan:

Store Tigan at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tigan out of the reach of children and away from pets.

General information:

  • If you have any questions about Tigan, please talk with your doctor, pharmacist, or other health care provider.
  • Tigan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Tigan or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Tigan. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Tigan. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Tigan.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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