Syprine

Generic Name: trientine (TRY-en-teen)
Brand Name: Syprine

Syprine is used for:

Treating Wilson disease in patients for whom other treatments are ineffective or not appropriate.

Syprine is a chelating compound. It works by binding to copper to help remove it from the body.

Do NOT use Syprine if:

  • you are allergic to any ingredient in Syprine

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

Before using Syprine:

Some medical conditions may interact with Syprine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have iron deficiency

Some MEDICINES MAY INTERACT with Syprine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Mineral supplements because the effectiveness of Syprine may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Syprine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Syprine:

Use Syprine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Syprine on an empty stomach at least 1 hour before or 2 hours after eating and at least 1 hour before or after taking any other drug, food, or milk.
  • Swallow Syprine whole. Do not break, crush, or chew before swallowing.
  • Take Syprine with water.
  • If you miss a dose of Syprine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Syprine.

Important safety information:

  • Patients receiving Syprine should remain under regular medical supervision throughout the period of drug administration. Patients, especially women, should be closely monitored for evidence of iron deficiency and anemia.
  • LAB TESTS, including serum iron, serum copper levels, urinary copper levels, and blood counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Syprine with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Syprine, discuss with your doctor the benefits and risks of using Syprine during pregnancy. It is unknown if Syprine is excreted in breast milk. If you are or will be breast-feeding while you are using Syprine, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Syprine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal muscle contractions or spasms; iron deficiency; lupus; muscle weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever; red, swollen, or blistered skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Syprine:

Store Syprine in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C), in a tightly closed container. Do not freeze. Keep Syprine out of the reach of children and away from pets.

General information:

  • If you have any questions about Syprine, please talk with your doctor, pharmacist, or other health care provider.
  • Syprine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Syprine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Syprine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Syprine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Syprine.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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