Generic Name: dasatinib (da-SA-ti-nib)
Brand Name: Sprycel
Sprycel is used for:
Treating certain types of leukemia. It may also be used for other conditions as determined by your doctor.
Sprycel is a tyrosine kinase inhibitor. It works by blocking proteins that cause the rapid growth of certain types of leukemia cells. This helps the bone marrow to start making normal blood cells again.
Do NOT use Sprycel if:
- you are allergic to any ingredient in Sprycel
- you are taking an H2 blocker (eg, famotidine), a proton pump inhibitor (eg, omeprazole), or St. John's wort
Contact your doctor or health care provider right away if any of these apply to you.
Before using Sprycel:
Some medical conditions may interact with Sprycel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, other substances
- if you are lactose intolerant. Sprycel contains lactose
- if you have liver problems, lung problems (eg, pulmonary arterial hypertension [PAH]), blood problems (eg, anemia, low blood potassium or magnesium levels, low platelet levels, low white blood cell levels), immune system problems, heart problems, or irregular heartbeat (eg, prolonged QT interval, congenital long QT syndrome)
- if you have not previously received treatment with imatinib or other therapies for leukemia
Some MEDICINES MAY INTERACT with Sprycel. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticoagulants (eg, heparin, warfarin), antiplatelet medicines (eg, clopidogrel), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of bleeding problems may be increased
- Anthracyclines (eg, doxorubicin), antiarrhythmics (eg, amiodarone, quinidine), arsenic, astemizole, bepridil, chloroquine, citalopram, cisapride, crizotinib, dolasetron, domperidone, doxepin, droperidol, halofantrine, haloperidol, iloperidone, maprotiline, methadone, nortriptyline, ondansetron, paliperidone, pentamidine, phenothiazines (eg, thioridazine), pimozide, quetiapine, quinolone antibiotics (eg, levofloxacin), romidepsin, tacrolimus, terfenadine, toremifene, vandetanib, or ziprasidone because the risk of severe and possibly fatal irregular heartbeat may be increased
- Azole antifungals (eg, ketoconazole), macrolide antibiotics (eg, clarithromycin, erythromycin), nefazodone, protease inhibitors (eg, boceprevir, ritonavir), or telithromycin because they may increase the risk of Sprycel's side effects
- Carbamazepine, dexamethasone, H2 blockers (eg, famotidine), hydantoins (eg, phenytoin), nevirapine, phenobarbital, primidone, proton pump inhibitors (eg, omeprazole), rifamycins (eg, rifabutin, rifampin), or St. John's wort because they may decrease Sprycel's effectiveness
- Alfentanil, cyclosporine, ergot derivatives (eg, ergotamine), fentanyl, or sirolimus because the risk of their side effects may be increased by Sprycel
This may not be a complete list of all interactions that may occur. Ask your health care provider if Sprycel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Sprycel:
Use Sprycel as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Sprycel. Talk to your pharmacist if you have questions about this information.
- Take Sprycel by mouth with or without food.
- Swallow Sprycel whole. Do not break, crush, or chew before swallowing.
- Do not eat grapefruit or drink grapefruit juice while you use Sprycel.
- Do not take an antacid within 2 hours before or 2 hours after you take Sprycel.
- Take Sprycel at the same time each day.
- Do not change your dose or stop taking Sprycel without first talking with your doctor.
- If you miss a dose of Sprycel, take your next scheduled dose at its regular time. Do not take 2 doses at once. Contact your doctor or pharmacist if you are unsure of what to do.
Ask your health care provider any questions you may have about how to use Sprycel.
Important safety information:
- Sprycel may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Sprycel with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Women who may become pregnant should use effective birth control while taking Sprycel. Check with your doctor if you have questions about using birth control.
- Women who are pregnant should avoid exposure to Sprycel if the tablet is accidentally crushed or broken.
- If you experience nausea, vomiting, diarrhea, or loss of appetite, talk with your doctor about ways to lessen these effects.
- Sprycel may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Sprycel may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Sprycel may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sprycel. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Sprycel may increase the risk of developing high blood pressure in your lungs (pulmonary arterial hypertension [PAH]). This may occur at anytime after starting Sprycel, including after more than 1 year of treatment. Discuss any questions or concerns with your doctor. Contact your doctor right away if you experience shortness of breath or trouble breathing, unusual tiredness, or unusual swelling.
- Tell your doctor or dentist that you take Sprycel before you receive any medical or dental care, emergency care, or surgery.
- Lab tests, including liver, lung, and heart function; blood electrolytes; and complete blood cell counts, may be performed while you use Sprycel. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Sprycel with caution in the ELDERLY; they may be more sensitive to its effects.
- Sprycel should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Sprycel may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Sprycel is found in breast milk. Do not breast-feed while taking Sprycel.
Possible side effects of Sprycel:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; diarrhea; dizziness; drowsiness; dry eyes; fatigue; hair loss; headache; joint or muscle pain; loss of appetite; nausea; stomach pain; taste changes; trouble sleeping; upset stomach; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bright red stools; blood in the vomit; burning, numbness, or tingling; calf or leg pain, tenderness, or swelling; change in the amount of urine produced; chest, jaw, or left arm pain; confusion; dark urine; dry cough; fainting; irregular heartbeat; irritation or sores in the mouth; mood or mental changes (eg, depression); numbness of an arm or leg; red, swollen, peeling, or blistered skin; ringing in the ears; seizures; severe or persistent diarrhea, headache, muscle or bone pain, nausea, stomach pain, or vomiting; severe or persistent tiredness or weakness; shortness of breath; signs of bleeding in the brain (eg, slurred speech, one-sided weakness, muscle weakness, loss of consciousness); signs of infection (eg, fever, chills, sore throat); unusual bruising or bleeding; unusual swelling or weight gain; vision changes (eg, blurred vision, decreased vision clearness); vomit that looks like coffee grounds; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Sprycel:
Store Sprycel at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sprycel out of the reach of children and away from pets.
- If you have any questions about Sprycel, please talk with your doctor, pharmacist, or other health care provider.
- Sprycel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Sprycel or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Sprycel. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Sprycel. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Sprycel.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.