Solifenacin

Pronunciation

Generic Name: solifenacin (SOE-li-FEN-a-sin)
Brand Name: VESIcare

Solifenacin is used for:

Treating overactive bladder with symptoms of an urgent need to urinate, a need to urinate often, or leakage of urine.

Solifenacin is a muscarinic receptor antagonist. It works by blocking the action of certain chemicals in the body to help decrease urination problems caused by overactive bladder.

Do NOT use solifenacin if:

  • you are allergic to any ingredient in solifenacin
  • you have uncontrolled narrow-angle glaucoma
  • you have severe liver problems
  • you are unable to empty your bladder (urinary retention) or have slow or delayed emptying of your stomach (gastric retention)
  • you are taking a solid oral potassium product (eg, tablet)

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: How to Manage Your Overactive Bladder

Before using solifenacin:

Some medical conditions may interact with solifenacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have stomach or bowel problems, constipation, difficulty urinating, or a weak urine stream
  • if you have narrow-angle glaucoma, liver or kidney problems, or a history of heart problems (eg, QT prolongation)
  • if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with solifenacin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Solid oral potassium product (eg, tablet) because the risk of stomach or bowel irritation may be increased by solifenacin
  • Azole antifungals (eg, itraconazole, ketoconazole), macrolide antibiotics (eg, clarithromycin), nefazodone, protease inhibitors (eg, boceprevir, ritonavir), or telithromycin because they may increase the risk of solifenacin's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if solifenacin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use solifenacin:

Use solifenacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with solifenacin. Talk to your pharmacist if you have questions about this information.
  • Take solifenacin by mouth with or without food.
  • Swallow solifenacin whole with water. Do not break, crush, or chew before swallowing.
  • Continue to take solifenacin even if you feel well. Do not miss any doses.
  • If you miss a dose of solifenacin, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses on the same day.

Ask your health care provider any questions you may have about how to use solifenacin.

Important safety information:

  • Solifenacin may cause drowsiness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use solifenacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Contact your doctor at once if you experience severe stomach pain or if you are constipated for 3 or more days.
  • Solifenacin may cause decreased sweating. Do not become overheated in hot weather or while you are being active; heatstroke may occur. Contact your doctor if you have been exposed to high temperatures and you develop fever; flushing; hot, dry skin; severe or persistent headache; dizziness; sudden or severe tiredness or weakness; fast heartbeat; seizures; or fainting.
  • Solifenacin may cause dry mouth. To help relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute. Ask your doctor or pharmacist if you have any questions.
  • A serious side effect called angioedema has been reported with the use of solifenacin. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
  • Use solifenacin with caution in the ELDERLY; they may be more sensitive to its effects.
  • Solifenacin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you are pregnant or planning to become pregnant, contact your doctor. You will need to discuss the benefits and risks of using solifenacin while you are pregnant. It is not known if solifenacin is found in breast milk. Do not breast-feed while taking solifenacin.

Possible side effects of solifenacin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; dry mouth; indigestion or stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); confusion; constipation lasting 3 or more days; decreased sweating; difficult or painful urination; fast, slow, or irregular heartbeat; hallucinations; mood or mental changes (eg, depression); redness or peeling of the skin; severe dizziness, tiredness, or nausea; severe stomach pain; swelling of the hands, ankles, or feet; unusual or severe headache.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; enlarged pupils; severe drowsiness; tremors; unusually dry skin.

Proper storage of solifenacin:

Store solifenacin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep solifenacin out of the reach of children and away from pets.

General information:

  • If you have any questions about solifenacin, please talk with your doctor, pharmacist, or other health care provider.
  • Solifenacin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take solifenacin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about solifenacin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to solifenacin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using solifenacin.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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