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Solage

Generic Name: mequinol/tretinoin (ME-kwi-nole/TREH-tih-noyn)
Brand Name: Solage

Solage is used for:

Treating solar lentigines (darkened lesions on skin that has been exposed to sunlight over a long period of time). Solage is used with a total skin care and sunlight avoidance program. It may also be used for other conditions as determined by your doctor.

Solage is a combination depigmentation agent and retinoid. Exactly how it works is unknown.

Do NOT use Solage if:

  • you are allergic to any ingredient in Solage
  • you are taking a fluoroquinolone (eg, levofloxacin), a phenothiazine (eg, chlorpromazine), a sulfonamide (eg, glipizide, sulfamethoxazole), a tetracycline (eg, doxycycline), a thiazide diuretic (eg, hydrochlorothiazide), or other medicines that may increase your skin's sensitivity to the sun. Ask your doctor or pharmacist if you have questions about whether any of your medicines increase your skin's sun sensitivity.
  • you are pregnant or may become pregnant

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Solage:

Some medical conditions may interact with Solage. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have eczema, irritated or inflamed skin, an increased number of white blood cells, vitiligo (loss of skin pigmentation), or sunburn
  • if you are unusually sensitive to sunlight or must be outside for prolonged periods of time

Some MEDICINES MAY INTERACT with Solage. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Fluoroquinolones (eg, levofloxacin), phenothiazines (eg, chlorpromazine), sulfonamides (eg, glipizide, sulfamethoxazole), tetracyclines (eg, doxycycline), or thiazide diuretics (eg, hydrochlorothiazide) because the risk of sunburn may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Solage may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Solage:

Use Solage as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Solage. Talk to your pharmacist if you have questions about this information.
  • Solage is for external use only.
  • Use Solage twice daily, at least 8 hours apart, unless directed otherwise by your doctor.
  • Remove all cosmetics with a mild soap before applying Solage. Gently dry the area. Wait 20 to 30 minutes to make sure that skin is completely dry.
  • Use the applicator tip to apply Solage to the affected area. Use only enough to make the lesion appear moist. Avoid getting Solage on the surrounding, normally colored skin.
  • Do not shower or bathe the treated areas for at least 6 hours after you apply Solage.
  • Wait 30 minutes after applying Solage before you apply cosmetics.
  • If you miss a dose of Solage, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Solage.

Important safety information:

  • Avoid getting Solage in your eyes, on the inside or angles of your nose, or in your mouth. If you get Solage in your eyes, rinse thoroughly with water.
  • Solage may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Solage. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Talk with your doctor before you use any other medicines or products on your skin. While you are using Solage, you may use cosmetics.
  • Do not apply Solage to skin that is sunburned. Wait until the burn is fully healed before using Solage.
  • Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Safety and effectiveness of Solage have not been established in patients with moderately dark to dark skin.
  • Avoid using other topical medication, cosmetics, or other products that have a strong drying effect. If you have dry skin from using these products, allow your skin to "rest" before using Solage.
  • If the lesion you have been treating becomes the same color as your normal skin, contact your doctor.
  • Do not use Solage on skin with eczema, or for any condition other than that for which it was prescribed.
  • Weather extremes, such as windy or cold weather, may irritate your skin more while you are using Solage.
  • Solage may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
  • Solage should only be used in addition to a comprehensive skin care and sunlight avoidance program prepared by your doctor.
  • Solage is flammable. Do not store or use near an open flame or while smoking.
  • If you are able to become pregnant, use effective birth control while you are using Solage.
  • Solage should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Solage if you are pregnant. If you think you may be pregnant, contact your doctor immediately. It is not known if Solage is found in breast milk. If you are or will be breast-feeding while you use Solage, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Solage:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning, dry skin, itching, peeling, redness, stinging, tingling, or warmth at application site; unusual sensitivity to wind and cold.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering, crusting, swelling, or excessive redness of the skin; changes in skin color; lightening of the skin surrounding the treatment area.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include clumsiness; dizziness; excessive redness, peeling, and discomfort; flushing; headache; stomach pain.

Proper storage of Solage:

Store Solage at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat and light. Do not store in the bathroom. Keep Solage out of the reach of children and away from pets.

General information:

  • If you have any questions about Solage, please talk with your doctor, pharmacist, or other health care provider.
  • Solage is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Solage or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Solage. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Solage. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Solage.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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