Sodium Sulfate/
Potassium Sulfate/
Magnesium Sulfate Solution

Pronunciation: SOE-dee-um SUL-fate/poe-TAS-ee-um SUL-fate/mag-NEE-zee-um SUL-fate
Generic Name: Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate
Brand Name: Suprep Bowel Prep Kit

Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution is used for:

Cleaning out the bowel before a certain procedure (colonoscopy). It may also be used for other conditions as determined by your doctor.

Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution is a laxative. It works by softening the stool and increasing the frequency of bowel movements by retaining water in the stool.

Do NOT use Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution if:

• you are allergic to any ingredient in Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution
• you have certain stomach or bowel problems (eg, blockage, retention, perforation, toxic inflammation, megacolon, ileus)
• you have abnormal blood electrolyte levels (eg, potassium, sodium, magnesium)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution:

Some medical conditions may interact with Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of blood electrolyte problems, seizures, kidney problems, gout, or stomach or bowel problems (eg, inflammatory bowel disease, ulcerative colitis)
• if you have a history of irregular heartbeat (eg, prolonged QT), a recent heart attack, a certain type of chest pain (unstable angina), or other heart problems (eg, congestive heart failure, heart muscle problems)
• if you are going through alcohol or benzodiazepine (eg, lorazepam) withdrawal
• if you have an impaired gag reflex, trouble swallowing, gastric reflux, or you are at risk of aspiration (inhaling foreign matter into the airway or lungs)
• if you are dehydrated or on a low-salt (sodium) diet
• if you also take other laxatives (eg, bisacodyl), or medicines for blood pressure, heart problems, kidney problems, or seizures

Some MEDICINES MAY INTERACT with Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Tricyclic antidepressants (eg, amitriptyline) because the risk of seizures may be increased
• Angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril), angiotensin receptor blockers (eg, valsartan), diuretics (eg, furosemide, hydrochlorothiazide), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution:

Use Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution refilled.
• Your doctor will tell you when to start using Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution.
• On the day before your procedure, you may have a light breakfast or clear liquids only. Do not eat dinner. Do not drink milk or alcoholic beverages. Do not eat or drink anything colored red or purple. Do not eat any solid foods from the time you start Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution until your procedure is complete.
• Drinking extra fluids before, during, and after you take Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution is recommended. Check with your doctor for instructions.
• Do NOT take Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution without first mixing it with water. Doing so may increase the risk of nausea, vomiting, and dehydration. Be sure you understand how to take Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution.
• Pour 1 bottle (6 ounces) of Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution into the mixing container. Add cool drinking water to the 16-ounce line on the container. Mix well. Drink all of the solution in the container. Drink 2 more 16-ounce containers of water over the next hour.
• Repeat using the second bottle of medicine on the morning of your procedure (10 to 12 hours after the first dose) unless your doctor tells you otherwise.
• You must finish drinking the final glass of water at least 1 hour before your procedure, unless your doctor tells you otherwise.
• Medicines taken by mouth within 1 hour of taking Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution may not be absorbed or be effective. Contact your doctor or pharmacist with any concerns you might have about taking your other medicines.
• If you miss your dose of Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution, take it as soon as you remember. Continue to take it as directed by your doctor. Notify your doctor right away if you are unable to finish taking Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution before your test.

Ask your health care provider any questions you may have about how to use Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution.

Important safety information:

• The following are examples of clear liquids that you may drink the day before and the day of your procedure: water, strained fruit juices without pulp (including apple, orange, white grape, or white cranberry), limeade or lemonade (without pulp), coffee or tea (without creamer), chicken broth, gelatin desserts without added fruit or topping (no red or purple). Check with your doctor or pharmacist if you have questions about whether you may drink a certain liquid.
• Contact your doctor right away if severe vomiting or diarrhea occurs, or if you become dehydrated after taking Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution. These effects may lead to abnormal blood electrolyte levels, which may cause certain serious side effects (eg, irregular heartbeat, kidney problems, seizures). Discuss any questions or concerns with your doctor.
• Do not take other laxatives (eg, bisacodyl) while you are taking Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution, unless your doctor tells you otherwise.
• Lab tests, including blood electrolyte levels, heart function, and kidney function, may be performed while you use Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution with caution in the ELDERLY; they may be more sensitive to its effects, especially vomiting.
• Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution while you are pregnant. It is not known if Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution is found in breast milk. If you are or will be breast-feeding while you take Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Discomfort; feeling of being full or bloated; mild stomach pain, cramping, or discomfort; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased urination; dizziness; fainting; headache; irregular heartbeat; seizures; severe diarrhea; severe or persistent stomach pain, bloating, cramping, or discomfort; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution:

Store Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution between 68 and 77 degrees F (20 and 25 degrees C) in its original container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Keep Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution, please talk with your doctor, pharmacist, or other health care provider.
• Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.
• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.