Simbrinza drops

Generic Name: brinzolamide/brimonidine (brin-ZOE-la-mide/bri-MON-i-deen)
Brand Name: Simbrinza

Simbrinza drops is used for:

Lowering eye pressure in patients with open-angle glaucoma or increased pressure of the eye (ocular hypertension).

Simbrinza drops is a carbonic anhydrase inhibitor and alpha-adrenergic agonist combination. It works by decreasing fluid production and pressure inside the eye.

Do NOT use Simbrinza drops if:

  • you are allergic to any ingredient in Simbrinza drops
  • the patient is a newborn or a child younger than 2 years old
  • you have severe kidney problems
  • you are taking another carbonic anhydrase inhibitor (eg, acetazolamide, methazolamide)
  • you are taking furazolidone, a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), or topiramate

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Simbrinza drops:

Some medical conditions may interact with Simbrinza drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide (sulfa) medicine (eg, sulfamethoxazole)
  • if you have heart, kidney, or liver problems
  • if you have a history of depression
  • if you have circulation problems (eg, Raynaud phenomenon), blood vessel problems (eg, in the brain, heart, or legs); or low blood pressure, especially upon standing
  • if you wear contact lenses
  • if you take digoxin or medicines for high blood pressure

Some MEDICINES MAY INTERACT with Simbrinza drops. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Furazolidone, linezolid, or MAOIs (eg, phenelzine) because the risk of their side effects, including high fever, high blood pressure, and headache, may be increased by Simbrinza drops
  • Entacapone, tolcapone, or topiramate because they may increase the risk of Simbrinza drops's side effects
  • Tricyclic antidepressants (eg, amitriptyline) because they may decrease Simbrinza drops's effectiveness
  • Barbiturates (eg, phenobarbital), bromocriptine, opioid pain medicines (eg, oxycodone), other carbonic anhydrase inhibitors (eg, acetazolamide, methazolamide), or salicylates (eg, aspirin) because the risk of their side effects may be increased by Simbrinza drops
  • Guanethidine because its effectiveness may be decreased by Simbrinza drops

This may not be a complete list of all interactions that may occur. Ask your health care provider if Simbrinza drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Simbrinza drops:

Use Simbrinza drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Shake well before each use.
  • Remove soft contact lenses before you use Simbrinza drops; lenses may be placed back in the eyes 15 minutes after use of Simbrinza drops.
  • To use Simbrinza drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
  • To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Always replace the cap after using. Keep the container tightly closed.
  • More than 1 eye medicine may be used to lower eye pressure. If you use other medicines in your eye, wait at least 5 minutes between using Simbrinza drops and your other eye medicines.
  • If Simbrinza drops changes color or becomes cloudy, do not use it. Do not use Simbrinza drops after the expiration date on the bottle.
  • If you miss a dose of Simbrinza drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Simbrinza drops.

Important safety information:

  • Simbrinza drops may cause drowsiness, dizziness, blurred vision, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Simbrinza drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol while you use Simbrinza drops.
  • Do NOT use more than the recommended dose or use more often than prescribed without checking with your doctor.
  • Contact your doctor if you have an eye injury or infection, or if you will be having eye surgery.
  • Lab tests, including eye exams, may be performed while you use Simbrinza drops. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Simbrinza drops should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Simbrinza drops while you are pregnant. It is not known if Simbrinza drops is found in breast milk. Do not breast-feed while using Simbrinza drops.

Possible side effects of Simbrinza drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; drowsiness; dry eyes; dry mouth; feeling that something is in the eye; headache; increased tear production; mild burning, itching, or redness of the eye; runny nose; taste changes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; depression; eye irritation, swelling, pain, or discharge; eyelid pain, redness, scaling, drooping, crusting, or swelling; fainting; irregular heartbeat; sensitivity to light; severe or persistent headache or dizziness; shortness of breath; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Simbrinza drops:

Store Simbrinza drops between 36 and 77 degrees F (2 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Simbrinza drops out of the reach of children and away from pets.

General information:

  • If you have any questions about Simbrinza drops, please talk with your doctor, pharmacist, or other health care provider.
  • Simbrinza drops is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Simbrinza drops or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Simbrinza drops. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Simbrinza drops. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Simbrinza drops.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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